Receptor-interacting protein kinase 4 and interferon regulatory factor 6 function as a signaling axis to regulate keratinocyte differentiation

scientific article

Receptor-interacting protein kinase 4 and interferon regulatory factor 6 function as a signaling axis to regulate keratinocyte differentiation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M114.589382
P932PMC publication ID4223312
P698PubMed publication ID25246526

P50authorEric C. ReynoldsQ38523882
Matthew J. SweetQ40050893
John A. HamiltonQ46648449
P2093author name stringThao Nguyen
Lianyi Zhang
Jennifer Huynh
Glen M Scholz
Mei Qi Kwa
Jiamin Aw
P2860cites workDIK, a novel protein kinase that interacts with protein kinase Cdelta. Cloning, characterization, and gene analysisQ24290109
Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locusQ24300588
RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis.Q24538893
Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromesQ24600400
Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lipQ24650690
Epidermal homeostasis: a balancing act of stem cells in the skinQ24654755
Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6)Q24675845
A new mathematical model for relative quantification in real-time RT-PCRQ27860781
Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent mannerQ28188812
Barrier function of the skin: "la raison d'être" of the epidermisQ28189520
Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinaseQ28207788
Popliteal pterygium syndrome . A syndrome comprising cleft lip-palate, popliteal and intercrural pterygia, digital and genital anomaliesQ28240948
Regulation of involucrin gene expressionQ28266509
Irf6 is a key determinant of the keratinocyte proliferation-differentiation switchQ28268504
The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4Q28505730
Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermisQ28584785
A homolog of Drosophila grainy head is essential for epidermal integrity in miceQ28585220
The mutational landscape of head and neck squamous cell carcinomaQ29614654
RIP4 is an ankyrin repeat-containing kinase essential for keratinocyte differentiationQ30844787
Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomasQ31814759
Interferon regulatory factor 6 differentially regulates Toll-like receptor 2-dependent chemokine gene expression in epithelial cells.Q33888640
Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signalingQ33889161
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristicsQ33962085
GRHL3/GET1 and trithorax group members collaborate to activate the epidermal progenitor differentiation programQ34350973
Popliteal pterygium syndrome. Evidence for a severe autosomal recessive formQ34634436
PKC-delta and -eta, MEKK-1, MEK-6, MEK-3, and p38-delta are essential mediators of the response of normal human epidermal keratinocytes to differentiating agentsQ35060332
Protein kinase C (PKC) delta suppresses keratinocyte proliferation by increasing p21(Cip1) level by a KLF4 transcription factor-dependent mechanismQ35309397
Interferon regulatory factor 6 is necessary, but not sufficient, for keratinocyte differentiationQ35613430
IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytesQ35626298
Mutations in RIPK4 cause the autosomal-recessive form of popliteal pterygium syndromeQ35671532
From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinomaQ35698913
Epidermal keratinocytes: regulation of multiple cell phenotypes by multiple protein kinase C isoformsQ35756424
The RIP kinases: crucial integrators of cellular stressQ36064232
Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcriptionQ36117420
The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms.Q36731651
Protein kinase C δ increases Kruppel-like factor 4 protein, which drives involucrin gene transcription in differentiating keratinocytesQ36929105
MYC in mammalian epidermis: how can an oncogene stimulate differentiation?Q37091735
The IRF family transcription factors in immunity and oncogenesisQ37096072
MAD1 and its life as a MYC antagonist: an update.Q37932115
Keratins as biochemical markers of epithelial differentiationQ38205755
Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expressionQ38305109
Terminal differentiation of epidermal keratinocytesQ38782850
Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switchQ40127834
Involucrin and Other Markers of Keratinocyte Terminal DifferentiationQ40151458
Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice.Q40238247
Protein kinase C-associated kinase (PKK) mediates Bcl10-independent NF-kappa B activation induced by phorbol esterQ40721472
The Mad1 transcription factor is a novel target of activin and TGF-beta action in keratinocytes: possible role of Mad1 in wound repair and psoriasisQ40762449
Interferon regulatory factor 6 promotes differentiation of the periderm by activating expression of Grainyhead-like 3.Q41919357
Protein kinase C regulates keratinocyte transglutaminase (TGK) gene expression in cultured primary mouse epidermal keratinocytes induced to terminally differentiate by calciumQ42491137
Calcium-dependent involucrin expression is inversely regulated by protein kinase C (PKC)alpha and PKCdeltaQ43895721
RIP4 regulates epidermal differentiation and cutaneous inflammation.Q45922587
Role of Rel/NF-kappaB transcription factors during the outgrowth of the vertebrate limb.Q46700056
Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis.Q52188586
Protein kinase C in normal human epidermal keratinocytes during proliferation and calcium-induced differentiationQ67579575
Bartsocas-Papas syndrome with internal anomalies: evidence for a more generalized epithelial defect or new syndrome?Q72547030
Two missense mutations of the IRF6 gene in two Japanese families with popliteal pterygium syndromeQ84966032
P4510describes a project that usesImageJQ1659584
P433issue45
P407language of work or nameEnglishQ1860
P921main subjectkeratinocyteQ1473931
P304page(s)31077-31087
P577publication date2014-09-22
P1433published inJournal of Biological ChemistryQ867727
P1476titleReceptor-interacting protein kinase 4 and interferon regulatory factor 6 function as a signaling axis to regulate keratinocyte differentiation
P478volume289

Reverse relations

cites work (P2860)
Q35579303A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes
Q41335460Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis
Q92648911Candidate tumor suppressor gene IRF6 is involved in human breast cancer pathogenesis via modulating PI3K-regulatory subunit PIK3R2 expression
Q38646959Disrupted IRF6-NME1/2 Complexes as a Cause of Cleft Lip/Palate
Q37501501Gene network analysis identifies rumen epithelial cell proliferation, differentiation and metabolic pathways perturbed by diet and correlated with methane production
Q38684025Grainyhead-like Transcription Factors in Craniofacial Development.
Q99553768IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation
Q40815050IRF6 Regulates the Expression of IL-36γ by Human Oral Epithelial Cells in Response to Porphyromonas gingivalis
Q35913541IRF6 is the mediator of TGFβ3 during regulation of the epithelial mesenchymal transition and palatal fusion
Q54262049Identification of a novel mutation in RIPK4 in a kindred with phenotypic features of Bartsocas-Papas and CHAND syndromes.
Q64914989Immune Control by TRAF6-Mediated Pathways of Epithelial Cells in the EIME (Epithelial Immune Microenvironment).
Q35976278Interferon Regulatory Factor 6 Has a Protective Role in the Host Response to Endotoxic Shock
Q38712376Interferon Regulatory Factor 6 Promotes Keratinocyte Differentiation in Response to Porphyromonas gingivalis
Q90468556Keratin 14 is a novel interaction partner of keratinocyte differentiation regulator: receptor-interacting protein kinase 4
Q28088384New insights into craniofacial malformations
Q36372615Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis.
Q49025492RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization.
Q89143062Regulation of the Peptidoglycan Amidase PGLYRP2 in Epithelial Cells by Interleukin-36γ
Q90442105The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function

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