Dose-dense sequential adjuvant chemotherapy followed, as indicated, by trastuzumab for one year in patients with early breast cancer: first report at 5-year median follow-up of a Hellenic Cooperative Oncology Group randomized phase III trial

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Dose-dense sequential adjuvant chemotherapy followed, as indicated, by trastuzumab for one year in patients with early breast cancer: first report at 5-year median follow-up of a Hellenic Cooperative Oncology Group randomized phase III trial is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1022928686
P356DOI10.1186/1471-2407-14-515
P932PMC publication ID4223601
P698PubMed publication ID25026897
P5875ResearchGate publication ID263971015

P50authorChristos ChristodoulouQ96038899
George FountzilasQ56432880
Urania DafniQ56605609
Christos MarkopoulosQ57033404
P2093author name stringParis Kosmidis
Dimitrios Pectasides
Nicholas Pavlidis
Christos N Papandreou
Helen Gogas
Pavlos Papakostas
Constantine Dimitrakakis
Anastasia G Eleftheraki
Angelos Koutras
Dimitrios Bafaloukos
Eleni Timotheadou
Ioannis Varthalitis
Ioannis Xanthakis
Meletios-Athanassios Dimopoulos
Panagiotis Korantzopoulos
Epaminontas Samantas
Charisios Karanikiotis
Christos Papadimitriou
Spyros Miliaras
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Weekly docetaxel versus CMF as adjuvant chemotherapy for elderly breast cancer patients: safety data from the multicentre phase 3 randomised ELDA trialQ31141377
Postoperative dose-dense sequential chemotherapy with epirubicin, paclitaxel and CMF in patients with high-risk breast cancer: safety analysis of the Hellenic Cooperative Oncology Group randomized phase III trial HE 10/00.Q33377581
Postoperative dose-dense sequential versus concomitant administration of epirubicin and paclitaxel in patients with node-positive breast cancer: 5-year results of the Hellenic Cooperative Oncology Group HE 10/00 phase III TrialQ57904482
Adjuvant dose-dense sequential chemotherapy with epirubicin, CMF, and weekly docetaxel is feasible and safe in patients with operable breast cancerQ79782943
Phase III multicenter trial of doxorubicin plus cyclophosphamide followed by paclitaxel compared with doxorubicin plus paclitaxel followed by weekly paclitaxel as adjuvant therapy for women with high-risk breast cancerQ84244064
Trastuzumab in the adjuvant treatment of HER2-positive early breast cancer patients: a meta-analysis of published randomized controlled trialsQ33939795
Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analysis of data from NCCTG N9831 and NSABP B-31.Q33964848
Theoretical concepts and the emerging role of taxanes in adjuvant therapyQ34247815
Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancerQ34496969
Weekly administration of docetaxel and paclitaxel in metastatic or advanced breast cancerQ34562115
Sequential versus concurrent trastuzumab in adjuvant chemotherapy for breast cancerQ35609706
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Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallQ43180234
Trastuzumab for patients with axillary-node-positive breast cancer: results of the FNCLCC-PACS 04 trialQ43241014
Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer TrialQ43250043
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Sequential versus concurrent anthracyclines and taxanes as adjuvant chemotherapy of early breast cancer: a meta-analysis of phase III randomized control trialsQ45335146
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Adjuvant dose-dense sequential chemotherapy with epirubicin, CMF and weekly paclitaxel in patients with resected high-risk breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) studyQ46528079
Randomized phase 3 trial of fluorouracil, epirubicin, and cyclophosphamide alone or followed by Paclitaxel for early breast cancer.Q46573303
A randomized phase III study comparing three anthracycline-free taxane-based regimens, as first line chemotherapy, in metastatic breast cancer: a Hellenic Cooperative Oncology Group studyQ46592751
Postoperative dose-dense sequential chemotherapy with epirubicin, followed by CMF with or without paclitaxel, in patients with high-risk operable breast cancer: a randomized phase III study conducted by the Hellenic Cooperative Oncology GroupQ46691182
2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): an open-label, randomised controlled trialQ47973074
Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: a 4-year follow-up of a randomised controlled trial.Q53158182
2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial.Q53243856
Randomized Phase III Trial of Weekly Compared With Every-3-Weeks Paclitaxel for Metastatic Breast Cancer, With Trastuzumab for all HER-2 Overexpressors and Random Assignment to Trastuzumab or Not in HER-2 Nonoverexpressors: Final Results of Cancer anQ57578399
P407language of work or nameEnglishQ1860
P921main subjecttrastuzumabQ412616
chemotherapyQ974135
phase III clinical trialQ42824827
P304page(s)515
P577publication date2014-07-15
P1433published inBMC CancerQ326300
P1476titleDose-dense sequential adjuvant chemotherapy followed, as indicated, by trastuzumab for one year in patients with early breast cancer: first report at 5-year median follow-up of a Hellenic Cooperative Oncology Group randomized phase III trial
P478volume14

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cites work (P2860)
Q36908374Delay in initiation of adjuvant trastuzumab therapy leads to decreased overall survival and relapse-free survival in patients with HER2-positive non-metastatic breast cancer
Q92083173Efficacy and safety of tailored and dose-dense adjuvant chemotherapy and trastuzumab for resected HER2-positive breast cancer: Results from the phase 3 PANTHER trial
Q35651423Evaluation of two highly-multiplexed custom panels for massively parallel semiconductor sequencing on paraffin DNA
Q35240718Gambogic Acid lysinate induces apoptosis in breast cancer mcf-7 cells by increasing reactive oxygen species
Q36009610Measurement of Domain-Specific HER2 (ERBB2) Expression May Classify Benefit From Trastuzumab in Breast Cancer
Q64110303Opposite Prognostic Impact of Single PTEN-loss and Mutations in Early High-risk Breast Cancer
Q36754437Survival in patients with non-metastatic breast cancer treated with adjuvant trastuzumab in clinical practice
Q37362747TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting
Q30251429Taxane acute pain syndrome (TAPS) in patients receiving taxane-based chemotherapy for breast cancer-a systematic review.
Q36782680Tumors with high-density tumor infiltrating lymphocytes constitute a favorable entity in breast cancer: a pooled analysis of four prospective adjuvant trials
Q91779956lncRNA GHET1 knockdown suppresses breast cancer activity in vitro and in vivo

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