scholarly article | Q13442814 |
P819 | ADS bibcode | 2003PNAS..100..473M |
P356 | DOI | 10.1073/PNAS.0237315100 |
P953 | full work available at URL | https://europepmc.org/articles/pmc141019?pdf=render |
P932 | PMC publication ID | 141019 |
P698 | PubMed publication ID | 12515859 |
P5875 | ResearchGate publication ID | 10960876 |
P7228 | access restriction status | open access | Q232932 |
P50 | author | Satoshi Ōmura | Q21061207 |
Kiyoshi Kita | Q38601152 | ||
P2093 | author name string | Hideto Miyoshi | |
Kazuro Shiomi | |||
Hideaki Ui | |||
Hiroshi Tomoda | |||
Hiroko Miyadera | |||
Rokuro Masuma | |||
Arihiro Osanai | |||
Yuichi Yamaguchi | |||
P2860 | cites work | Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution | Q27620575 |
Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site | Q27637861 | ||
An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria | Q28345186 | ||
The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway | Q28361936 | ||
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma | Q28366764 | ||
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma | Q29614552 | ||
Chronic systemic pesticide exposure reproduces features of Parkinson's disease | Q29614763 | ||
Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans. | Q32186139 | ||
Isolation, characterization and sequence of a gene conferring resistance to the systemic fungicide carboxin from the maize smut pathogen, Ustilago maydis | Q33369300 | ||
Simple redox-linked proton-transfer design: new insights from structures of quinol-fumarate reductase | Q33836882 | ||
Role of complex II in anaerobic respiration of the parasite mitochondria from Ascaris suum and Plasmodium falciparum | Q33956962 | ||
Phenotypic dichotomy in mitochondrial complex II genetic disorders. | Q34427068 | ||
Inborn errors of complex II--unusual human mitochondrial diseases | Q34501870 | ||
Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates | Q35082127 | ||
Succinate: quinone oxidoreductases. Variations on a conserved theme | Q41520455 | ||
Mechanism of action of atpenin B on Raji cells. | Q41722748 | ||
Germline SDHD mutation in familial phaeochromocytoma | Q43588788 | ||
The ubiquinol/bc1 redox couple regulates mitochondrial oxygen radical formation | Q43613581 | ||
Nafuredin, a novel inhibitor of NADH-fumarate reductase, produced by Aspergillus niger FT-0554. | Q43617058 | ||
Novel mutations in the SDHD gene in pedigrees with familial carotid body paraganglioma and sensorineural hearing loss | Q43629699 | ||
Nearly all hereditary paragangliomas in the Netherlands are caused by two founder mutations in the SDHD gene | Q43629703 | ||
The carboxin-binding site on Paracoccus denitrificans succinate:quinone reductase identified by mutations | Q43676719 | ||
A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans | Q43723433 | ||
Rotenone inhibits the mitochondrial permeability transition-induced cell death in U937 and KB cells | Q43723445 | ||
Purification, crystallisation and preliminary crystallographic studies of succinate:ubiquinone oxidoreductase from Escherichia coli | Q43861522 | ||
Comparison of the structures of the quinone-binding sites in beef heart mitochondria | Q46626713 | ||
A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes | Q47068796 | ||
The electron transport chain in anaerobically functioning eukaryotes | Q47729670 | ||
Mutations in SDHC cause autosomal dominant paraganglioma, type 3. | Q47817141 | ||
Carboxin resistance in Paracoccus denitrificans conferred by a mutation in the membrane-anchor domain of succinate:quinone reductase. | Q47928751 | ||
A single amino-acid substitution in the iron-sulphur protein subunit of succinate dehydrogenase determines resistance to carboxin in Mycosphaerella graminicola | Q47998414 | ||
A single amino-acid change in the iron-sulphur protein subunit of succinate dehydrogenase confers resistance to carboxin in Ustilago maydis | Q48163595 | ||
Electron-transfer complexes of Ascaris suum muscle mitochondria. III. Composition and fumarate reductase activity of complex II. | Q54742020 | ||
Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma | Q55670916 | ||
Stage-specific Isoforms of Complex II (Succinate-Ubiquinone Oxidoreductase) in Mitochondria from the Parasitic Nematode,Ascaris suum | Q58853786 | ||
One-step purification from Escherichia coli of complex II (succinate: ubiquinone oxidoreductase) associated with succinate-reducible cytochrome b556 | Q58853799 | ||
Atpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physico-chemical and biological properties | Q68001575 | ||
The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp | Q68659564 | ||
Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum | Q72901520 | ||
Total synthesis of nafuredin, a selective NADH-fumarate reductase inhibitor | Q74235076 | ||
Structure and biosynthesis of harzianopyridone, an antifungal metabolite of Trichoderma harzianum | Q104999458 | ||
Biological Activity of(-)-Harzianopyridone Isolated from Trichoderma harzianum. | Q104999459 | ||
Nafuredin, a Novel Inhibitor of NADH-fumarate Reductase, Produced by Aspergillus niger FT-0554. | Q105181719 | ||
P433 | issue | 2 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | Penicillium oxalicum | Q10623016 |
3-(2,4-dimethylhexanoyl)-4-hydroxy-5,6-dimethoxy-1H-pyridin-2-one | Q105277555 | ||
P6954 | online access status | open access | Q232932 |
P304 | page(s) | 473-477 | |
P577 | publication date | 2003-01-06 | |
P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
P1476 | title | Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase). | |
P478 | volume | 100 |
Q94251709 | A dispensable paralog of succinate dehydrogenase subunit C mediates standing resistance towards a subclass of SDHI fungicides in Zymoseptoria tritici |
Q52320281 | A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency. |
Q37199352 | A spectrophotometric coupled enzyme assay to measure the activity of succinate dehydrogenase |
Q59098977 | Accumulation of succinate controls activation of adipose tissue thermogenesis |
Q28471810 | Acute inhibition of selected membrane-proximal mouse T cell receptor signaling by mitochondrial antagonists |
Q36769281 | Advances in drug discovery and biochemical studies |
Q39527969 | Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells |
Q28485299 | Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin |
Q34416087 | An analysis of the effects of Mn2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays |
Q36108255 | Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration |
Q56026301 | Antisense inhibition of the iron-sulphur subunit of succinate dehydrogenase enhances photosynthesis and growth in tomato via an organic acid-mediated effect on stomatal aperture |
Q40786331 | Bioisosteric Exchange of Csp3 -Chloro and Methyl Substituents: Synthesis and Initial Biological Studies of Atpenin A5 Analogues |
Q42471810 | Calcium signalling-dependent mitochondrial dysfunction and bioenergetics regulation in respiratory chain Complex II deficiency. |
Q46475003 | Choline and dimethylglycine produce superoxide/hydrogen peroxide from the electron transport chain in liver mitochondria |
Q36578312 | Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate |
Q41953091 | Crystallization of mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum with the specific inhibitor flutolanil |
Q36981764 | Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction |
Q47823611 | Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities. |
Q39789933 | Differential metabolic responses to pluronic in MDR and non-MDR cells: a novel pathway for chemosensitization of drug resistant cancers. |
Q36839612 | Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death |
Q47850962 | Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors |
Q44059270 | Dynamic Energy Dependency of Chlamydia trachomatis on Host Cell Metabolism during Different Stages of Intracellular Growth: Possible role of Sodium -based energetics in Chlamydial ATP generation |
Q38746656 | Ecological functions of Trichoderma spp. and their secondary metabolites in the rhizosphere: interactions with plants |
Q40421777 | Effects of organophosphorus compounds on ATP production and mitochondrial integrity in cultured cells |
Q37701708 | Electron-transfer pathways in the heme and quinone-binding domain of complex II (succinate dehydrogenase). |
Q44184140 | Enantioselective total synthesis of atpenin A5. |
Q52311055 | Experimental autoimmune encephalomyelitis (EAE) up-regulates the mitochondrial activity and manganese superoxide dismutase (MnSOD) in the mouse renal cortex. |
Q41830350 | Expression of Saccharomyces cerevisiae Sdh3p and Sdh4p paralogs results in catalytically active succinate dehydrogenase isoenzymes |
Q38239799 | Fungal natural products in research and development. |
Q90162788 | Glutaminases as a Novel Target for SDHB-Associated Pheochromocytomas/Paragangliomas |
Q36419289 | Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine |
Q37921677 | Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell death. |
Q39396806 | Inhibitory effects of respiration inhibitors on aflatoxin production. |
Q38084631 | Mitochondria as a pharmacological target: magnum overview |
Q39129680 | Mitochondrial Complex II: At the Crossroads |
Q35879792 | Mitochondrial ROS Metabolism: 10 Years Later |
Q51764903 | Mitochondrial complex II Is essential for gametophyte development in Arabidopsis. |
Q36137552 | Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions |
Q47973346 | Mitochondrial complex II regulates a distinct oxygen sensing mechanism in monocytes |
Q46211758 | Mitochondrial dehydrogenases in the aerobic respiratory chain of the rodent malaria parasite Plasmodium yoelii yoelii |
Q37657133 | Mitochondrial diaphorases as NAD⁺ donors to segments of the citric acid cycle that support substrate-level phosphorylation yielding ATP during respiratory inhibition. |
Q37882392 | Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer? |
Q92402318 | Mitoflash biogenesis and its role in the autoregulation of mitochondrial proton electrochemical potential |
Q33926010 | Mutation of the heme axial ligand of Escherichia coli succinate-quinone reductase: implications for heme ligation in mitochondrial complex II from yeast |
Q39873573 | New atpenins, NBRI23477 A and B, inhibit the growth of human prostate cancer cells. |
Q61801536 | Novel Characteristics of Mitochondrial Electron Transport Chain from |
Q43167112 | Novel mitochondrial complex II isolated from Trypanosoma cruzi is composed of 12 peptides including a heterodimeric Ip subunit |
Q58853750 | Paecilaminol, a New NADH-Fumarate Reductase Inhibitor, Produced by Paecilomyces sp. FKI-0550 |
Q36845488 | Parasitic nematodes - from genomes to control. |
Q27002338 | Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel |
Q41509991 | Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production. |
Q92295532 | Pseudomonas aeruginosa Increases the Sensitivity of Biofilm-Grown Staphylococcus aureus to Membrane-Targeting Antiseptics and Antibiotics |
Q42293000 | Respiratory Complex I in Bos taurus and Paracoccus denitrificans Pumps Four Protons across the Membrane for Every NADH Oxidized. |
Q46416600 | Salicylic Acid-Dependent Plant Stress Signaling via Mitochondrial Succinate Dehydrogenase |
Q41546549 | Sartorypyrone D: a new NADH-fumarate reductase inhibitor produced by Neosartorya fischeri FO-5897. |
Q63916359 | Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2 |
Q58858620 | Siccanin Is a Novel Selective Inhibitor of Trypanosomatid Complex II (Succinate-Ubiquinone Reductase) and a Potent Broad-Spectrum Anti-trypanosomatid Drug Candidate |
Q33464047 | Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor |
Q37412145 | Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria. |
Q41763256 | Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria |
Q28291140 | Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction |
Q42948652 | Succinate cytochrome c reductase in schistosomiasis: in vitro inhibition by some schistosomicidal drugs. |
Q46713872 | Succinate dehydrogenase (mitochondrial complex II) is a source of reactive oxygen species in plants and regulates development and stress responses. |
Q37036859 | Sulfonylurea receptor-dependent and -independent pathways mediate vasodilation induced by ATP-sensitive K+ channel openers |
Q48122945 | Synthesis and Antineoplastic Evaluation of Mitochondrial Complex II (Succinate Dehydrogenase) Inhibitors Derived from Atpenin A5. |
Q38748591 | The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells |
Q28554455 | The Open Form Inducer Approach for Structure-Based Drug Design |
Q39363477 | The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection |
Q37419750 | The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels |
Q90737470 | The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A |
Q33647869 | The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria |
Q97561747 | The newborn Fmr1 knockout mouse: a novel model of excess ubiquinone and closed mitochondrial permeability transition pore in the developing heart |
Q27671605 | Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature |
Q58855723 | Trichoderma harzianum strain T-22 induces changes in phytohormone levels in cherry rootstocks (Prunus cerasus × P. canescens) |
Q28395613 | Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation |
Q58853753 | Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083 |