Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase).

scholarly article

Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase). is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2003PNAS..100..473M
P356DOI10.1073/PNAS.0237315100
P953full work available at URLhttps://europepmc.org/articles/pmc141019?pdf=render
P932PMC publication ID141019
P698PubMed publication ID12515859
P5875ResearchGate publication ID10960876

P7228access restriction statusopen accessQ232932
P50authorSatoshi ŌmuraQ21061207
Kiyoshi KitaQ38601152
P2093author name stringHideto Miyoshi
Kazuro Shiomi
Hideaki Ui
Hiroshi Tomoda
Hiroko Miyadera
Rokuro Masuma
Arihiro Osanai
Yuichi Yamaguchi
P2860cites workStructure of fumarate reductase from Wolinella succinogenes at 2.2 A resolutionQ27620575
Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding siteQ27637861
An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondriaQ28345186
The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathwayQ28361936
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paragangliomaQ28366764
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paragangliomaQ29614552
Chronic systemic pesticide exposure reproduces features of Parkinson's diseaseQ29614763
Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans.Q32186139
Isolation, characterization and sequence of a gene conferring resistance to the systemic fungicide carboxin from the maize smut pathogen, Ustilago maydisQ33369300
Simple redox-linked proton-transfer design: new insights from structures of quinol-fumarate reductaseQ33836882
Role of complex II in anaerobic respiration of the parasite mitochondria from Ascaris suum and Plasmodium falciparumQ33956962
Phenotypic dichotomy in mitochondrial complex II genetic disorders.Q34427068
Inborn errors of complex II--unusual human mitochondrial diseasesQ34501870
Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediatesQ35082127
Succinate: quinone oxidoreductases. Variations on a conserved themeQ41520455
Mechanism of action of atpenin B on Raji cells.Q41722748
Germline SDHD mutation in familial phaeochromocytomaQ43588788
The ubiquinol/bc1 redox couple regulates mitochondrial oxygen radical formationQ43613581
Nafuredin, a novel inhibitor of NADH-fumarate reductase, produced by Aspergillus niger FT-0554.Q43617058
Novel mutations in the SDHD gene in pedigrees with familial carotid body paraganglioma and sensorineural hearing lossQ43629699
Nearly all hereditary paragangliomas in the Netherlands are caused by two founder mutations in the SDHD geneQ43629703
The carboxin-binding site on Paracoccus denitrificans succinate:quinone reductase identified by mutationsQ43676719
A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegansQ43723433
Rotenone inhibits the mitochondrial permeability transition-induced cell death in U937 and KB cellsQ43723445
Purification, crystallisation and preliminary crystallographic studies of succinate:ubiquinone oxidoreductase from Escherichia coliQ43861522
Comparison of the structures of the quinone-binding sites in beef heart mitochondriaQ46626713
A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodesQ47068796
The electron transport chain in anaerobically functioning eukaryotesQ47729670
Mutations in SDHC cause autosomal dominant paraganglioma, type 3.Q47817141
Carboxin resistance in Paracoccus denitrificans conferred by a mutation in the membrane-anchor domain of succinate:quinone reductase.Q47928751
A single amino-acid substitution in the iron-sulphur protein subunit of succinate dehydrogenase determines resistance to carboxin in Mycosphaerella graminicolaQ47998414
A single amino-acid change in the iron-sulphur protein subunit of succinate dehydrogenase confers resistance to carboxin in Ustilago maydisQ48163595
Electron-transfer complexes of Ascaris suum muscle mitochondria. III. Composition and fumarate reductase activity of complex II.Q54742020
Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytomaQ55670916
Stage-specific Isoforms of Complex II (Succinate-Ubiquinone Oxidoreductase) in Mitochondria from the Parasitic Nematode,Ascaris suumQ58853786
One-step purification from Escherichia coli of complex II (succinate: ubiquinone oxidoreductase) associated with succinate-reducible cytochrome b556Q58853799
Atpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physico-chemical and biological propertiesQ68001575
The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium spQ68659564
Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatumQ72901520
Total synthesis of nafuredin, a selective NADH-fumarate reductase inhibitorQ74235076
Structure and biosynthesis of harzianopyridone, an antifungal metabolite of Trichoderma harzianumQ104999458
Biological Activity of(-)-Harzianopyridone Isolated from Trichoderma harzianum.Q104999459
Nafuredin, a Novel Inhibitor of NADH-fumarate Reductase, Produced by Aspergillus niger FT-0554.Q105181719
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectPenicillium oxalicumQ10623016
3-(2,4-dimethylhexanoyl)-4-hydroxy-5,6-dimethoxy-1H-pyridin-2-oneQ105277555
P6954online access statusopen accessQ232932
P304page(s)473-477
P577publication date2003-01-06
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleAtpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase).
P478volume100

Reverse relations

cites work (P2860)
Q94251709A dispensable paralog of succinate dehydrogenase subunit C mediates standing resistance towards a subclass of SDHI fungicides in Zymoseptoria tritici
Q52320281A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency.
Q37199352A spectrophotometric coupled enzyme assay to measure the activity of succinate dehydrogenase
Q59098977Accumulation of succinate controls activation of adipose tissue thermogenesis
Q28471810Acute inhibition of selected membrane-proximal mouse T cell receptor signaling by mitochondrial antagonists
Q36769281Advances in drug discovery and biochemical studies
Q39527969Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells
Q28485299Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin
Q34416087An analysis of the effects of Mn2+ on oxidative phosphorylation in liver, brain, and heart mitochondria using state 3 oxidation rate assays
Q36108255Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration
Q56026301Antisense inhibition of the iron-sulphur subunit of succinate dehydrogenase enhances photosynthesis and growth in tomato via an organic acid-mediated effect on stomatal aperture
Q40786331Bioisosteric Exchange of Csp3 -Chloro and Methyl Substituents: Synthesis and Initial Biological Studies of Atpenin A5 Analogues
Q42471810Calcium signalling-dependent mitochondrial dysfunction and bioenergetics regulation in respiratory chain Complex II deficiency.
Q46475003Choline and dimethylglycine produce superoxide/hydrogen peroxide from the electron transport chain in liver mitochondria
Q36578312Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate
Q41953091Crystallization of mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum with the specific inhibitor flutolanil
Q36981764Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction
Q47823611Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities.
Q39789933Differential metabolic responses to pluronic in MDR and non-MDR cells: a novel pathway for chemosensitization of drug resistant cancers.
Q36839612Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death
Q47850962Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors
Q44059270Dynamic Energy Dependency of Chlamydia trachomatis on Host Cell Metabolism during Different Stages of Intracellular Growth: Possible role of Sodium -based energetics in Chlamydial ATP generation
Q38746656Ecological functions of Trichoderma spp. and their secondary metabolites in the rhizosphere: interactions with plants
Q40421777Effects of organophosphorus compounds on ATP production and mitochondrial integrity in cultured cells
Q37701708Electron-transfer pathways in the heme and quinone-binding domain of complex II (succinate dehydrogenase).
Q44184140Enantioselective total synthesis of atpenin A5.
Q52311055Experimental autoimmune encephalomyelitis (EAE) up-regulates the mitochondrial activity and manganese superoxide dismutase (MnSOD) in the mouse renal cortex.
Q41830350Expression of Saccharomyces cerevisiae Sdh3p and Sdh4p paralogs results in catalytically active succinate dehydrogenase isoenzymes
Q38239799Fungal natural products in research and development.
Q90162788Glutaminases as a Novel Target for SDHB-Associated Pheochromocytomas/Paragangliomas
Q36419289Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine
Q37921677Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell death.
Q39396806Inhibitory effects of respiration inhibitors on aflatoxin production.
Q38084631Mitochondria as a pharmacological target: magnum overview
Q39129680Mitochondrial Complex II: At the Crossroads
Q35879792Mitochondrial ROS Metabolism: 10 Years Later
Q51764903Mitochondrial complex II Is essential for gametophyte development in Arabidopsis.
Q36137552Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions
Q47973346Mitochondrial complex II regulates a distinct oxygen sensing mechanism in monocytes
Q46211758Mitochondrial dehydrogenases in the aerobic respiratory chain of the rodent malaria parasite Plasmodium yoelii yoelii
Q37657133Mitochondrial diaphorases as NAD⁺ donors to segments of the citric acid cycle that support substrate-level phosphorylation yielding ATP during respiratory inhibition.
Q37882392Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?
Q92402318Mitoflash biogenesis and its role in the autoregulation of mitochondrial proton electrochemical potential
Q33926010Mutation of the heme axial ligand of Escherichia coli succinate-quinone reductase: implications for heme ligation in mitochondrial complex II from yeast
Q39873573New atpenins, NBRI23477 A and B, inhibit the growth of human prostate cancer cells.
Q61801536Novel Characteristics of Mitochondrial Electron Transport Chain from
Q43167112Novel mitochondrial complex II isolated from Trypanosoma cruzi is composed of 12 peptides including a heterodimeric Ip subunit
Q58853750Paecilaminol, a New NADH-Fumarate Reductase Inhibitor, Produced by Paecilomyces sp. FKI-0550
Q36845488Parasitic nematodes - from genomes to control.
Q27002338Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel
Q41509991Pleiotropic Effects of Biguanides on Mitochondrial Reactive Oxygen Species Production.
Q92295532Pseudomonas aeruginosa Increases the Sensitivity of Biofilm-Grown Staphylococcus aureus to Membrane-Targeting Antiseptics and Antibiotics
Q42293000Respiratory Complex I in Bos taurus and Paracoccus denitrificans Pumps Four Protons across the Membrane for Every NADH Oxidized.
Q46416600Salicylic Acid-Dependent Plant Stress Signaling via Mitochondrial Succinate Dehydrogenase
Q41546549Sartorypyrone D: a new NADH-fumarate reductase inhibitor produced by Neosartorya fischeri FO-5897.
Q63916359Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2
Q58858620Siccanin Is a Novel Selective Inhibitor of Trypanosomatid Complex II (Succinate-Ubiquinone Reductase) and a Potent Broad-Spectrum Anti-trypanosomatid Drug Candidate
Q33464047Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor
Q37412145Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria.
Q41763256Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria
Q28291140Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction
Q42948652Succinate cytochrome c reductase in schistosomiasis: in vitro inhibition by some schistosomicidal drugs.
Q46713872Succinate dehydrogenase (mitochondrial complex II) is a source of reactive oxygen species in plants and regulates development and stress responses.
Q37036859Sulfonylurea receptor-dependent and -independent pathways mediate vasodilation induced by ATP-sensitive K+ channel openers
Q48122945Synthesis and Antineoplastic Evaluation of Mitochondrial Complex II (Succinate Dehydrogenase) Inhibitors Derived from Atpenin A5.
Q38748591The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells
Q28554455The Open Form Inducer Approach for Structure-Based Drug Design
Q39363477The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection
Q37419750The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels
Q90737470The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A
Q33647869The mitochondrial complex II and ATP-sensitive potassium channel interaction: quantitation of the channel in heart mitochondria
Q97561747The newborn Fmr1 knockout mouse: a novel model of excess ubiquinone and closed mitochondrial permeability transition pore in the developing heart
Q27671605Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature
Q58855723Trichoderma harzianum strain T-22 induces changes in phytohormone levels in cherry rootstocks (Prunus cerasus × P. canescens)
Q28395613Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation
Q58853753Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083