Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective

scientific article

Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2015PNAS..112E2245K
P356DOI10.1073/PNAS.1500439112
P932PMC publication ID4418888
P698PubMed publication ID25848045

P50authorDonald C. LoQ116821905
Denise E. DunnQ116821968
P2093author name stringBrent R Stockwell
Arthur G Palmer
Lewis M Brown
Anna Kaplan
Ryan Colligan
Michael M Gaschler
P2860cites workNuclear magnetic resonance characterization of the N-terminal thioredoxin-like domain of protein disulfide isomeraseQ24675311
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsQ27861111
A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening AssaysQ28145712
Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosisQ28277961
Impaired assembly of the major histocompatibility complex class I peptide-loading complex in mice deficient in the oxidoreductase ERp57Q28283909
A single polypeptide acts both as the beta subunit of prolyl 4-hydroxylase and as a protein disulfide-isomeraseQ28288295
Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agentsQ30514535
Overexpressed protein disulfide isomerase in brains of patients with sporadic Creutzfeldt-Jakob diseaseQ30871448
A cell-based screen for drugs to treat Huntington's diseaseQ31096167
A high-throughput turbidometric assay for screening inhibitors of protein disulfide isomerase activityQ31119993
A critical role for extracellular protein disulfide isomerase during thrombus formation in miceQ33320817
Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteinsQ33747446
Discovery of a small molecule PDI inhibitor that inhibits reduction of HIV-1 envelope glycoprotein gp120.Q33759766
Small Molecule that Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL).Q33889062
Ferroptosis: an iron-dependent form of nonapoptotic cell deathQ34032093
Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress.Q34051194
Bacitracin is not a specific inhibitor of protein disulfide isomeraseQ34115847
Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomeraseQ34999928
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivoQ36289970
Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatmentQ36342774
Using chemical shift perturbation to characterise ligand bindingQ38130403
Protein disulfide isomerase knockdown-induced cell death is cell-line-dependent and involves apoptosis in MCF-7 cellsQ39597096
Protein-disulfide isomerase-mediated reduction of two disulfide bonds of HIV envelope glycoprotein 120 occurs post-CXCR4 binding and is required for fusionQ40705636
Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assayQ42741104
Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex.Q44566241
Functional properties of the individual thioredoxin-like domains of protein disulfide isomeraseQ71715190
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)E2245-52
P577publication date2015-04-06
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleSmall molecule-induced oxidation of protein disulfide isomerase is neuroprotective
P478volume112

Reverse relations

cites work (P2860)
Q27331600A substrate-driven allosteric switch that enhances PDI catalytic activity
Q64123337Adolescent idiopathic scoliosis associated POC5 mutation impairs cell cycle, cilia length and centrosome protein interactions
Q39362347Advances in vascular thiol isomerase function
Q92424151Allosteric regulation of protein 14-3-3ζ scaffold by small-molecule editing modulates histone H3 post-translational modifications
Q51742416Characterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor.
Q47299185Discovery and Mechanistic Elucidation of a Class of Protein Disulfide Isomerase Inhibitors for the Treatment of Glioblastoma.
Q38646083Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE.
Q40506281Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana).
Q64277533Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes
Q57471782Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma
Q61807618Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics
Q89807991MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling
Q33808212Machine Learning and Network Analysis of Molecular Dynamics Trajectories Reveal Two Chains of Red/Ox-specific Residue Interactions in Human Protein Disulfide Isomerase.
Q93188487Modifications of disulfide bonds in breast cancer cell migration and invasiveness
Q93055870Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists
Q91601674Pathological consequences of the unfolded protein response and downstream protein disulphide isomerases in pulmonary viral infection and disease
Q38992384Protein Disulphide Isomerases: emerging roles of PDI and ERp57 in the nervous system and as therapeutic targets for ALS.
Q90589313Protein disulfide isomerase in cardiovascular disease
Q90013470Protein profiling of SH-SY5Y neuroblastoma cells: The effect of rhein
Q52692554Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease.
Q35821021Structural Elucidation of a Small Molecule Inhibitor of Protein Disulfide Isomerase
Q90644438Toxicant-mediated redox control of proteostasis in neurodegeneration
Q99564889Tumor cells rely on the thiol oxidoreductase PDI for PERK signaling in order to survive ER stress

Search more.