Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases

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Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1534/GENETICS.114.168096
P932PMC publication ID4224181
P698PubMed publication ID25205745

P50authorJeff SekelskyQ38359280
P2093author name stringKathryn P Kohl
H Kenny Kuo
Christopher M Rota
Susan McMahan
P2860cites workCoordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repairQ24313572
Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombinationQ24313650
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repairQ24314301
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleasesQ24314357
Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctionsQ24337537
Meiotic versus mitotic recombination: two different routes for double-strand break repair: the different functions of meiotic versus mitotic DSB repair are reflected in different pathway usage and different outcomesQ24597411
The Bloom's syndrome gene product promotes branch migration of holliday junctionsQ24674127
Combinatorial regulation of meiotic holliday junction resolution in C. elegans by HIM-6 (BLM) helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 nucleasesQ27321712
Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.Q27929966
Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiaeQ27931342
Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3.Q27932379
Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonucleaseQ27935913
Identification of Holliday junction resolvases from humans and yeastQ27937498
Human Mus81-associated endonuclease cleaves Holliday junctions in vitroQ28210371
BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolismQ28264465
FANCM limits meiotic crossoversQ28269373
Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosisQ28513559
Generating crossovers by resolution of nicked Holliday junctions: a role for Mus81-Eme1 in meiosisQ28647386
The fission yeast FANCM ortholog directs non-crossover recombination during meiosisQ28729084
Evidence for multiple cycles of strand invasion during repair of double-strand gaps in DrosophilaQ28768697
The Bloom's syndrome helicase suppresses crossing over during homologous recombinationQ29547237
Mus81-Eme1 are essential components of a Holliday junction resolvaseQ29619843
piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruningQ43076987
Aberrant chromosome morphology in human cells defective for Holliday junction resolutionQ43100849
The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repairQ43244381
The Fanconi anemia ortholog FANCM ensures ordered homologous recombination in both somatic and meiotic cells in ArabidopsisQ44946342
Drosophila homologs of FANCD2 and FANCL function in DNA repairQ47070120
Drosophila BLM in double-strand break repair by synthesis-dependent strand annealingQ47071772
Sterility of Drosophila with mutations in the Bloom syndrome gene--complementation by Ku70.Q47072630
The in vivo genetic activity profile of the monofunctional nitrogen mustard 2-chloroethylamine differs drastically from its bifunctional counterpart mechlorethamine.Q50722756
Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M.Q51629652
Relationship of DNA double-strand breaks to synapsis in Drosophila.Q52608121
Fanconi anemiaQ82905436
The role of AtMUS81 in interference-insensitive crossovers in A. thalianaQ33294063
Fly-TILL: reverse genetics using a living point mutation resourceQ33394752
Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in DrosophilaQ33628866
Meiotic recombination intermediates are resolved with minimal crossover formation during return-to-growth, an analogue of the mitotic cell cycleQ33921194
The Drosophila meiotic recombination gene mei-9 encodes a homologue of the yeast excision repair protein Rad1.Q33965874
Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotesQ34025948
Three structure-selective endonucleases are essential in the absence of BLM helicase in DrosophilaQ34055346
Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathwayQ34285356
Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeastQ34492648
End-joining repair of double-strand breaks in Drosophila melanogaster is largely DNA ligase IV independentQ34569414
The Mus81/Mms4 Endonuclease Acts Independently of Double-Holliday Junction Resolution to Promote a Distinct Subset of Crossovers During Meiosis in Budding YeastQ34617616
Heteroduplex DNA position defines the roles of the Sgs1, Srs2, and Mph1 helicases in promoting distinct recombination outcomesQ34629211
Mutational analysis of the Drosophila DNA repair and recombination gene mei-9Q34644455
The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forksQ34738472
Drosophila MUS312 interacts with the nucleotide excision repair endonuclease MEI-9 to generate meiotic crossoversQ35507009
Multiple functions of Drosophila BLM helicase in maintenance of genome stabilityQ35945619
Synthetic lethality of Drosophila in the absence of the MUS81 endonuclease and the DmBlm helicase is associated with elevated apoptosis.Q35945625
DNA helicases involved in DNA repair and their roles in cancerQ35961508
Making crossovers during meiosisQ36295514
Evolution of an MCM complex in flies that promotes meiotic crossovers by blocking BLM helicaseQ36690708
Mph1 and Mus81-Mms4 prevent aberrant processing of mitotic recombination intermediatesQ37283116
An essential role of DmRad51/SpnA in DNA repair and meiotic checkpoint controlQ37368057
Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion.Q37595768
The FANCM family of DNA helicases/translocases.Q37684306
Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agentsQ37939678
Saccharomyces cerevisiae Mus81-Mms4 is a catalytic, DNA structure-selective endonucleaseQ38293464
Binding and melting of D-loops by the Bloom syndrome helicaseQ38306431
Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cellsQ38312294
Mph1 requires mismatch repair-independent and -dependent functions of MutSalpha to regulate crossover formation during homologous recombination repairQ39844167
Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing.Q40101630
The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway.Q40382206
Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases.Q42933602
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
Bloom syndrome helicase Dmel_CG6920Q29815004
Fanconi anemia group M helicase Dmel_CG7922Q29815027
Mutagen-sensitive 312 Dmel_CG8601Q29817304
P304page(s)935-945
P577publication date2014-09-08
P1433published inGeneticsQ3100575
P1476titleDrosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases
P478volume198

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cites work (P2860)
Q36297096Annealing of Complementary DNA Sequences During Double-Strand Break Repair in Drosophila Is Mediated by the Ortholog of SMARCAL1.
Q41642463Biochemical Activities and Genetic Functions of the Drosophila melanogaster Fancm Helicase in DNA Repair
Q39116605DNA Repair in Drosophila: Mutagens, Models, and Missing Genes
Q26784076Functions and regulation of the multitasking FANCM family of DNA motor proteins
Q39336514Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast
Q37746456Human Cell Assays for Synthesis-Dependent Strand Annealing and Crossing over During Double-Strand Break Repair
Q64240708Long live the queen, the king and the commoner? Transcript expression differences between old and young in the termite Cryptotermes secundus
Q42735314Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2.
Q52853455[Fanconi anemia animal models - How differences can teach us as much as similarities…].

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