Identification of a novel fosfomycin-resistant UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from a soil metagenome

scientific article

Identification of a novel fosfomycin-resistant UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from a soil metagenome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10529-012-1074-5
P698PubMed publication ID23143172

P2093author name stringJing Li
Baoli Zhu
Gong Cheng
Na Lu
Yongfei Hu
Zhiyun Wang
Quanze Chen
P2860cites workStructure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycinQ27734363
Clustal W and Clustal X version 2.0Q27860517
The metagenomics of soilQ33216317
Fosfomycin for the treatment of infections caused by multidrug-resistant non-fermenting Gram-negative bacilli: a systematic review of microbiological, animal and clinical studiesQ33436519
Functional metagenomics for enzyme discovery: challenges to efficient screeningQ33511915
Novel florfenicol and chloramphenicol resistance gene discovered in Alaskan soil by using functional metagenomicsQ33602714
Characterization of novel antibiotic resistance genes identified by functional metagenomics on soil samples.Q33807727
The mechanism of action of fosfomycin (phosphonomycin)Q34214482
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistanceQ34514901
Call of the wild: antibiotic resistance genes in natural environmentsQ37700168
Purification of a glutathione S-transferase that mediates fosfomycin resistance in bacteriaQ39815931
Metagenomic analysis of apple orchard soil reveals antibiotic resistance genes encoding predicted bifunctional proteinsQ41967842
Molecular mechanisms of fosfomycin resistance in clinical isolates of Escherichia coliQ43195414
Functional metagenomics reveals diverse beta-lactamases in a remote Alaskan soilQ47651450
Alteration of a single amino acid residue reverses fosfomycin resistance of recombinant MurA from Mycobacterium tuberculosisQ47904411
Lyme disease enolpyruvyl-UDP-GlcNAc synthase: fosfomycin-resistant MurA from Borrelia burgdorferi, a fosfomycin-sensitive mutant, and the catalytic role of the active site Asp.Q48060200
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.Q54590227
P433issue2
P304page(s)273-278
P577publication date2012-11-10
P1433published inBiotechnology LettersQ4915332
P1476titleIdentification of a novel fosfomycin-resistant UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from a soil metagenome
P478volume35

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cites work (P2860)
Q51773259Computed insight into a peptide inhibitor preventing the induced fit mechanism of MurA enzyme from Pseudomonas aeruginosa.
Q38973296Functional Metagenomics as a Tool for Identification of New Antibiotic Resistance Genes from Natural Environments

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