scholarly article | Q13442814 |
P819 | ADS bibcode | 2015Sci...350...94L |
P356 | DOI | 10.1126/SCIENCE.AAB1785 |
P932 | PMC publication ID | 4664477 |
P698 | PubMed publication ID | 26430121 |
P5875 | ResearchGate publication ID | 282428504 |
P50 | author | Christopher A. Walsh | Q23135514 |
Mollie B Woodworth | Q56757022 | ||
Amir D Karger | Q57422847 | ||
Bhaven K Mehta | Q58002447 | ||
Thomas W. Chittenden | Q89564461 | ||
P2093 | author name string | Eunjung Lee | |
Peter J Park | |||
Semin Lee | |||
Soohyun Lee | |||
Lovelace J Luquette | |||
Gilad D Evrony | |||
Alissa M D'Gama | |||
Xuyu Cai | |||
Michael A Lodato | |||
P2860 | cites work | Gene ontology: tool for the unification of biology | Q23781406 |
Mutational heterogeneity in cancer and the search for new cancer-associated genes | Q24606956 | ||
A map of human genome variation from population-scale sequencing | Q24617794 | ||
VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing | Q24628978 | ||
Fast and accurate short read alignment with Burrows-Wheeler transform | Q24653853 | ||
The KEGG resource for deciphering the genome | Q27860687 | ||
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data | Q27860742 | ||
The somatic genomic landscape of glioblastoma | Q28300185 | ||
Somatic mutation, genomic variation, and neurological disease | Q28395313 | ||
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data | Q29547161 | ||
A framework for variation discovery and genotyping using next-generation DNA sequencing data | Q29547262 | ||
The UCSC Genome Browser database: update 2010 | Q29614173 | ||
Integrative analysis of 111 reference human epigenomes | Q29615565 | ||
Global epigenomic reconfiguration during mammalian brain development | Q29617800 | ||
Mosaic copy number variation in human neurons | Q30409886 | ||
Rapid amplification of plasmid and phage DNA using Phi 29 DNA polymerase and multiply-primed rolling circle amplification | Q31920623 | ||
Single-cell genomic sequencing using Multiple Displacement Amplification | Q33301988 | ||
Mutation detection by real-time PCR: a simple, robust and highly selective method | Q33412122 | ||
Sequencing newly replicated DNA reveals widespread plasticity in human replication timing | Q33591861 | ||
Evolution in health and medicine Sackler colloquium: Somatic evolutionary genomics: mutations during development cause highly variable genetic mosaicism with risk of cancer and neurodegeneration. | Q33844436 | ||
Gene ontology analysis for RNA-seq: accounting for selection bias | Q33861598 | ||
Transcriptional landscape of the prenatal human brain | Q33926910 | ||
Genome coverage and sequence fidelity of phi29 polymerase-based multiple strand displacement whole genome amplification | Q33978394 | ||
Clonal evolution in breast cancer revealed by single nucleus genome sequencing. | Q34041603 | ||
Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor | Q34258285 | ||
Characterization of whole genome amplified (WGA) DNA for use in genotyping assay development | Q34289301 | ||
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples | Q34327021 | ||
Somatic mosaicism in healthy human tissues | Q34628543 | ||
Single-cell, genome-wide sequencing identifies clonal somatic copy-number variation in the human brain | Q34743417 | ||
Cell lineage analysis in human brain using endogenous retroelements. | Q34986445 | ||
Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt | Q35174434 | ||
A quantitative comparison of single-cell whole genome amplification methods | Q35227833 | ||
Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin | Q35752935 | ||
Genome-wide single-cell analysis of recombination activity and de novo mutation rates in human sperm | Q36475986 | ||
Single-neuron sequencing analysis of L1 retrotransposition and somatic mutation in the human brain | Q36595672 | ||
Systematic widespread clonal organization in cerebral cortex | Q36690947 | ||
Transcription induces strand-specific mutations at the 5' end of human genes | Q36804846 | ||
The landscape of microsatellite instability in colorectal and endometrial cancer genomes | Q37412188 | ||
Characteristics of the cation cotransporter NKCC1 in human brain: alternate transcripts, expression in development, and potential relationships to brain function and schizophrenia | Q37679314 | ||
Variation in the mutation rate across mammalian genomes | Q37942062 | ||
Structural genetic variation in the context of somatic mosaicism | Q37974097 | ||
The SCN1A gene variants and epileptic encephalopathies | Q38123956 | ||
DNA damage and its links to neurodegeneration | Q38230583 | ||
Human mutation rate associated with DNA replication timing | Q42085559 | ||
Deterministic progenitor behavior and unitary production of neurons in the neocortex. | Q42130570 | ||
Genome sequencing of normal cells reveals developmental lineages and mutational processes | Q42997512 | ||
Transcription-associated mutational asymmetry in mammalian evolution | Q44337576 | ||
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation | Q45823928 | ||
Radial and horizontal deployment of clonally related cells in the primate neocortex: Relationship to distinct mitotic lineages | Q71988390 | ||
P433 | issue | 6256 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 94-98 | |
P577 | publication date | 2015-10-01 | |
P1433 | published in | Science | Q192864 |
P1476 | title | Somatic mutation in single human neurons tracks developmental and transcriptional history | |
P478 | volume | 350 |
Q52614656 | A Postgenomic Perspective on Molecular Cytogenetics. |
Q59590801 | A characterization of postzygotic mutations identified in monozygotic twins |
Q38669058 | A comparative strategy for single-nucleus and single-cell transcriptomes confirms accuracy in predicted cell-type expression from nuclear RNA. |
Q37383356 | A generic, cost-effective, and scalable cell lineage analysis platform |
Q36942027 | A genome editing primer for the hematologist |
Q46320596 | APP/Aβ structural diversity and Alzheimer's disease pathogenesis |
Q28550230 | Accuracy of Answers to Cell Lineage Questions Depends on Single-Cell Genomics Data Quality and Quantity |
Q92453598 | Accurate detection of mosaic variants in sequencing data without matched controls |
Q40285035 | Accurate identification of single-nucleotide variants in whole-genome-amplified single cells |
Q47271432 | Aging and neurodegeneration are associated with increased mutations in single human neurons. |
Q48309999 | Aging and the rise of somatic cancer-associated mutations in normal tissues |
Q78176987 | Artificial intelligence for precision medicine in neurodevelopmental disorders. |
Q61447370 | Assessment of somatic single-nucleotide variation in brain tissue of cases with schizophrenia |
Q53420766 | Behavioral Variability and Somatic Mosaicism: A Cytogenomic Hypothesis. |
Q53838776 | Beyond Enumeration: Functional and Computational Analysis of Circulating Tumor Cells to Investigate Cancer Metastasis. |
Q47874535 | Beyond genome-wide significance: integrative approaches to the interpretation and extension of GWAS findings for alcohol use disorder. |
Q41016751 | Biphasic response as a mechanism against mutant takeover in tissue homeostasis circuits. |
Q39026618 | Brain transcriptome atlases: a computational perspective |
Q36256840 | Building a lineage from single cells: genetic techniques for cell lineage tracking |
Q55692870 | Cancer Diagnosis Using a Liquid Biopsy: Challenges and Expectations. |
Q54946976 | Cancer Is to Embryology as Mutation Is to Genetics: Hypothesis of the Cancer as Embryological Phenomenon. |
Q89687029 | CellTagging: combinatorial indexing to simultaneously map lineage and identity at single-cell resolution |
Q38909245 | Cellular identity at the single-cell level |
Q92074591 | Cellular labeling of endogenous retrovirus replication (CLEVR) reveals de novo insertions of the gypsy retrotransposable element in cell culture and in both neurons and glial cells of aging fruit flies |
Q53668059 | Cognitive genomics: Linking genes to behavior in the human brain. |
Q42373878 | Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory? |
Q64092158 | Conbase: a software for unsupervised discovery of clonal somatic mutations in single cells through read phasing |
Q38667277 | Contrasting Determinants of Mutation Rates in Germline and Soma |
Q47747851 | Copy Number Variation Analysis of 100 Twin Pairs Enriched for Neurodevelopmental Disorders |
Q39239920 | DEPDC5 as a potential therapeutic target for epilepsy |
Q61444494 | DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients |
Q58090488 | DSMNC: a database of somatic mutations in normal cells |
Q90505786 | Deciphering Brain Complexity Using Single-cell Sequencing |
Q93195867 | Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration |
Q88582770 | Detecting Somatic Mutations in Normal Cells |
Q30835928 | Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models |
Q33701930 | Differences between germline and somatic mutation rates in humans and mice |
Q47927504 | Different mutational rates and mechanisms in human cells at pregastrulation and neurogenesis. |
Q38939764 | Disentangling neural cell diversity using single-cell transcriptomics |
Q58610002 | Dissecting human disease with single-cell omics: application in model systems and in the clinic |
Q53820712 | Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organs. |
Q28078561 | Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease |
Q89723844 | Emerging Frontiers in the Study of Molecular Evolution |
Q39130435 | Endogenous DNA Damage as a Source of Genomic Instability in Cancer |
Q64102444 | Entanglement of Genetics and Epigenetics in Parkinson's Disease |
Q39091292 | Epigenetic Research in Neuropsychiatric Disorders: the "Tissue Issue". |
Q62868133 | Epilepsy |
Q58708119 | Evaluating Tumor Evolution via Genomic Profiling of Individual Tumor Spheroids in a Malignant Ascites |
Q41716411 | FAM222B Is Not a Likely Novel Candidate Gene for Cerebral Cavernous Malformations |
Q33882207 | Fate and freedom in developing neocortical circuits |
Q55435872 | Four-dimensional, dynamic mosaicism is a hallmark of normal human skin that permits mapping of the organization and patterning of human epidermis during terminal differentiation. |
Q28395874 | Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging |
Q38770485 | From Mutational Mechanisms in Single Cells to Mutational Patterns in Cancer Genomes |
Q90442301 | Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms |
Q36104710 | Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing |
Q60960849 | Genomic mosaicism in the developing and adult brain |
Q39200166 | Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy |
Q28392173 | Growth conditions that increase or decrease lifespan in Saccharomyces cerevisiae lead to corresponding decreases or increases in rates of interstitial deletions and non-reciprocal translocations |
Q55514131 | Haplotype phasing in single-cell DNA-sequencing data. |
Q50116899 | Haplotype resolution at the single-cell level |
Q50920727 | Hematopoiesis Lineage Tree Uprooted: Every Cell Is a Rainbow. |
Q57464755 | High prevalence of focal and multi-focal somatic genetic variants in the human brain |
Q46754703 | High-Resolution Single-Cell Sequencing of Malaria Parasites |
Q93332893 | Human Brain Single Nucleotide Polymorphism: Validation of DNA Sequencing |
Q37605380 | Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress |
Q89784447 | Human transposon insertion profiling by sequencing (TIPseq) to map LINE-1 insertions in single cells |
Q92036446 | Identification of differentially expressed genes by single-cell transcriptional profiling of umbilical cord and synovial fluid mesenchymal stem cells |
Q92994676 | Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance |
Q92377102 | Illegitimate and Repeated Genomic Integration of Cell-Free Chromatin in the Aetiology of Somatic Mosaicism, Ageing, Chronic Diseases and Cancer |
Q37580548 | In Utero Exposure to Benzo[a]Pyrene Increases Mutation Burden in the Soma and Sperm of Adult Mice |
Q91785772 | In vivo pulse labeling of isochronic cohorts of cells in the central nervous system using FlashTag |
Q64945385 | Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain. |
Q36897892 | Increased neuronal death and disturbed axonal growth in the Polμ-deficient mouse embryonic retina |
Q26776362 | Independent origins of neurons and synapses: insights from ctenophores |
Q64785219 | Induced pluripotent stem cell-based modeling of mutant LRRK2-associated Parkinson's disease |
Q33893730 | Influence of donor age on induced pluripotent stem cells |
Q89944661 | Inherited Eye Diseases with Retinal Manifestations through the Eyes of Homeobox Genes |
Q55010030 | Insights into the role of somatic mosaicism in the brain. |
Q91272514 | Integrative single-cell analysis |
Q35892749 | Interpreting the Dependence of Mutation Rates on Age and Time |
Q39268078 | Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network |
Q55692166 | L1 retrotransposition in the soma: a field jumping ahead. |
Q57798900 | Large-scale reconstruction of cell lineages using single-cell readout of transcriptomes and CRISPR-Cas9 barcodes by scGESTALT |
Q57295558 | Leveraging single-cell genomics to expand the fungal tree of life |
Q88656991 | Lineage Plasticity in Cancer Progression and Treatment |
Q92083738 | Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics |
Q90814608 | Lineage tracing meets single-cell omics: opportunities and challenges |
Q92461621 | Linked-read analysis identifies mutations in single-cell DNA-sequencing data |
Q92007123 | Longitudinal assessment of clonal mosaicism in human hematopoiesis via mitochondrial mutation tracking |
Q47362697 | Low number of fixed somatic mutations in a long-lived oak tree. |
Q98394754 | Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling |
Q37623036 | Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains |
Q30491801 | Molecular fingerprinting of principal neurons in the rodent hippocampus: A neuroinformatics approach |
Q91441152 | Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development |
Q38784278 | Mosaicism in health and disease - clones picking up speed |
Q58611494 | Multiple transmissions of de novo mutations in families |
Q28389468 | Mutation and Human Exceptionalism: Our Future Genetic Load |
Q52148556 | NEUROSCIENCE. A tree of the human brain. |
Q33878427 | NGSCheckMate: software for validating sample identity in next-generation sequencing studies within and across data types. |
Q92500890 | Natural and pathogenic protein sequence variation affecting prion-like domains within and across human proteomes |
Q46263952 | Neural lineage tracing in the mammalian brain |
Q47133918 | Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease |
Q37288678 | Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain. |
Q28073446 | New insights into the generation and role of de novo mutations in health and disease |
Q51041546 | Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry. |
Q48275067 | One brain, many genomes |
Q40446420 | One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative origin. |
Q52331906 | Opportunities and obstacles for deep learning in biology and medicine. |
Q57294401 | PHLI-seq: constructing and visualizing cancer genomic maps in 3D by phenotype-based high-throughput laser-aided isolation and sequencing |
Q55037627 | PIK-ing the right gene for polymicrogyria. |
Q47396987 | PaSD-qc: quality control for single cell whole-genome sequencing data using power spectral density estimation |
Q40341875 | Puzzles in modern biology. IV. Neurodegeneration, localized origin and widespread decay. |
Q60309641 | Quantification of somatic mutation flow across individual cell division events by lineage sequencing |
Q90007450 | RETrace: simultaneous retrospective lineage tracing and methylation profiling of single cells |
Q93086985 | Recording development with single cell dynamic lineage tracing |
Q36723382 | Resolving rates of mutation in the brain using single-neuron genomics |
Q90321264 | Retrotransposon-induced mosaicism in the neural genome |
Q38862587 | Review: Induced pluripotent stem cell models of frontotemporal dementia |
Q64911835 | Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion. |
Q48861138 | Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex |
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Q30277781 | Single neuron transcriptome analysis can reveal more than cell type classification: Does it matter if every neuron is unique? |
Q42777917 | Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns |
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Q34045945 | Single-cell genome sequencing: current state of the science |
Q42799232 | Single-cell genomics: coming of age |
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Q97643289 | Single-cell omics in ageing: a young and growing field |
Q41197100 | Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI). |
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Q47155966 | Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias. |
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Q37179645 | Somatic Variants in the Human Lens Epithelium: A Preliminary Assessment |
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Q53209256 | Somatic mosaicism: on the road to cancer. |
Q50308998 | Somatic mutagenesis in satellite cells associates with human skeletal muscle aging |
Q57167354 | Somatic mutation load and spectra: A record of DNA damage and repair in healthy human cells |
Q92877262 | Somatic mutation that affects transcription factor binding upstream of CD55 in the temporal cortex of a late-onset Alzheimer disease patient |
Q55259931 | Somatic mutations in neurons during aging and neurodegeneration. |
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Q30277198 | The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning |
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Q89948704 | The multiplex model of the genetics of Alzheimer's disease |
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Q64814697 | The role of de novo mutations in adult-onset neurodegenerative disorders. |
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Q64064330 | The use of technical replication for detection of low-level somatic mutations in next-generation sequencing |
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