Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

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Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI25790
P932PMC publication ID1421348
P698PubMed publication ID16585964

P2093author name stringMasayuki Yamamoto
Thomas W Kensler
Sekhar P Reddy
Hannah Lee
Rajesh K Thimmulappa
Shyam Biswal
Tirumalai Rangasamy
P2860cites workDefective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 GeneQ22299417
Toll-like receptor signallingQ24570126
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of careQ27860820
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene productQ28141458
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathwayQ28190704
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarrayQ28202142
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elementsQ28244853
Nrf2-Keap1 defines a physiologically important stress response mechanismQ28291002
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxinQ28306447
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathwayQ28592087
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient miceQ29615438
The immunopathogenesis of sepsisQ29622909
Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanismQ33836992
Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB.Q33989830
Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expressionQ34149788
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acidQ34301299
Increased C5a receptor expression in sepsisQ34793122
Glutathione depletion impairs myogenic differentiation of murine skeletal muscle C2C12 cells through sustained NF-kappaB activationQ35103083
Regulatory effects of iNOS on acute lung inflammatory responses in miceQ35843243
Arginine metabolic enzymes, nitric oxide and infectionQ35909728
Dysregulation of the immune response in severe sepsisQ35919320
Genetic polymorphisms and sepsis.Q36276888
Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolitesQ36376598
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infectionQ36402648
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in miceQ36402881
Antibodies against CD14 protect primates from endotoxin-induced shockQ37360210
MCP-1 protects mice in lethal endotoxemiaQ37368530
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in miceQ37591945
Achieving stability of lipopolysaccharide-induced NF-kappaB activationQ38320977
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survivalQ38359163
Nuclear import and export signals in control of Nrf2.Q40420771
IRF3 mediates a TLR3/TLR4-specific antiviral gene programQ40700858
Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B.Q40799748
Expression of the protein kinase C substrate pleckstrin in macrophages: association with phagosomal membranes.Q40930602
Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbitsQ41017625
The role of nuclear factor-kappa B in cytokine gene regulationQ41532089
Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cellsQ44041831
Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemiaQ44491825
Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B.Q44757031
Aberrant Toll receptor expression and endotoxin hypersensitivity in mice lacking a functional TGF-beta 1 signaling pathwayQ47991617
Defect in neutrophil killing and increased susceptibility to infection with nonpathogenic gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)-deficient miceQ48254949
Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects.Q53873432
Endotoxemia in transgenic mice overexpressing human glutathione peroxidasesQ56975923
Neutrophil recruitment and increased permeability during acute lung injury induced by lipopolysaccharideQ73186251
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectsepsisQ183134
P304page(s)984-995
P577publication date2006-04-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleNrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
P478volume116

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Q42155559Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide
Q57125103Nrf2-mediated anti-oxidant effects contribute to suppression of non-alcoholic steatohepatitis-associated hepatocellular carcinoma in murine model
Q34533982Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation
Q34032853Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice
Q37081392Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress
Q46299719Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion
Q36919246Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury
Q30275291Nuclear Factor (Erythroid-Derived 2)-Like 2 and Thioredoxin-1 in Atherosclerosis and Ischemia/Reperfusion Injury in the Heart
Q37542609Nuclear Factor E2-Related Factor-2 Negatively Regulates NLRP3 Inflammasome Activity by Inhibiting Reactive Oxygen Species-Induced NLRP3 Priming
Q28383171Nuclear Factor-Erythroid-2-Related Factor 2 in Aging and Lung Fibrosis
Q34104811Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract
Q38087926Nuclear factor (erythroid-derived 2)-like-2 factor (Nrf2), a key regulator of the antioxidant response to protect against atherosclerosis and nonalcoholic steatohepatitis
Q28387955Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation
Q41852354Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive element binding protein/activating transcription factor 1 signaling.
Q34389786Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells
Q58699616Overexpression of homeodomain-interacting protein kinase 2 (HIPK2) attenuates sepsis-mediated liver injury by restoring autophagy
Q35943342Oxidant-induced cell death and Nrf2-dependent antioxidative response are controlled by Fra-1/AP-1
Q43256970Oxidative stress in sepsis: a redox redux
Q90345158PL201, a Reported Rhamnoside Against Alzheimer's Disease Pathology, Alleviates Neuroinflammation and Stimulates Nrf2 Signaling
Q42560760PPARγ and Oxidative Stress: Con(β) Catenating NRF2 and FOXO
Q35577209Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2.
Q40346229Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption
Q38620104Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils
Q38442075Preconditioning by Low Dose LPS Prevents Subsequent LPS-Induced Severe Liver Injury via Nrf2 Activation in Mice
Q101226483Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice
Q35852621Protective Effect of the Fruit Hull of Gleditsia sinensis on LPS-Induced Acute Lung Injury Is Associated with Nrf2 Activation
Q54217591Protective Role of Nuclear Factor Erythroid 2-Related Factor 2 Against Respiratory Syncytial Virus and Human Metapneumovirus Infections.
Q28391645Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line
Q46615389Protective effects of sulforaphane on di-n-butylphthalate-induced testicular oxidative stress injury in male mice offsprings via activating Nrf2/ARE pathway
Q36684314Protective role of nuclear factor erythroid 2-related factor 2 in the hemorrhagic shock-induced inflammatory response
Q41500103Proteomic analysis of brain protein expression levels in NF-kappabeta p50 -/- homozygous knockout mice
Q89701868Pyrocatechol, a component of coffee, suppresses LPS-induced inflammatory responses by inhibiting NF-κB and activating Nrf2
Q37620581RETRACTED ARTICLE: Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κB inactivation
Q29615229ROS function in redox signaling and oxidative stress
Q33724561ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function
Q35512908RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity
Q39324573Recombinant adenovirus Ad-RUNrf2 reduces paraquat-induced A549 injury.
Q58221929Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation opposite modulation of JAK/STAT and Nrf2 pathways
Q27000279Redox control of microglial function: molecular mechanisms and functional significance
Q34138063Regenerative stromal cell therapy in allogeneic hematopoietic stem cell transplantation: current impact and future directions
Q58749129Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus
Q28354293Regressive Effect of Myricetin on Hepatic Steatosis in Mice Fed a High-Fat Diet
Q24655260Regulation of glutathione synthesis
Q37765106Regulation of innate immune responses by autophagy-related proteins
Q34731017Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells
Q39426145Resveratrol protects against lipopolysaccharide-induced cardiac dysfunction by enhancing SERCA2a activity through promoting the phospholamban oligomerization
Q37122677Retinal microenvironment imbalance in dry age-related macular degeneration: a mini-review
Q41816145Role of Nrf2 in host defense against influenza virus in cigarette smoke-exposed mice
Q37853027Role of glutathione in immunity and inflammation in the lung
Q36634711Role of lung maintenance program in the heterogeneity of lung destruction in emphysema
Q38750932Role of microRNAs in sepsis
Q38237494Role of the Nrf2 signaling system in health and disease
Q27026726Roles nrf2 plays in myeloid cells and related disorders
Q28594591Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock
Q100427974SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
Q35857245Selective and nonselective packaging of cellular RNAs in retrovirus particles
Q43203144Sepsis: redox mechanisms and therapeutic opportunities
Q37696365Sesamin inhibits IL-1β-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway
Q91638165Sikyungbanha-Tang Suppressing Acute Lung Injury in Mice Is Related to the Activation of Nrf2 and TNFAIP3
Q40386699Skin Damage Mechanisms Related to Airborne Particulate Matter Exposure
Q89964433Stress Memory of Recurrent Environmental Challenges in Marine Invasive Species: Ciona robusta as a Case Study
Q60048684Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding
Q37402358Sulforaphane Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and NLRP3 Inflammatory Pathway
Q39576582Sulforaphane inhibits de novo synthesis of IL-8 and MCP-1 in human epithelial cells generated by cigarette smoke extract
Q51595565Sulforaphane is anticonvulsant and improves mitochondrial function.
Q40240331Sulforaphane reduces lipopolysaccharide-induced proinflammatory markers in hippocampus and liver but does not improve sickness behavior
Q46302495Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation
Q34374994Suppression of lung inflammation in an LPS-induced acute lung injury model by the fruit hull of Gleditsia sinensis
Q35040534Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice
Q39931462Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation
Q36293645Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.
Q90122888Tanshinone IIA pretreatment promotes cell survival in human lung epithelial cells under hypoxia via AP-1-Nrf2 transcription factor
Q36178212Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice
Q37054081Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model
Q38786854Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression
Q28396391Th2 skewing by activation of Nrf2 in CD4(+) T cells
Q38837451The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update
Q28385998The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells
Q28391095The Nrf2 activator, tBHQ, differentially affects early events following stimulation of Jurkat cells
Q38114031The Nrf2 pathway in the progression of renal disease
Q34984506The Nrf2-ARE cytoprotective pathway in astrocytes
Q26741190The Role of Cyclo(His-Pro) in Neurodegeneration
Q55384251The Role of Mitophagy in Innate Immunity.
Q89621868The Role of Nrf2 in Cellular Innate Immune Response to Inflammatory Injury
Q92702814The Role of Nrf2 in the Antioxidant Cellular Response to Medical Ozone Exposure
Q57051340The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson's Disease
Q35865287The absence of Nrf2 enhances NF-κB-dependent inflammation following scratch injury in mouse primary cultured astrocytes
Q30495467The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis
Q39295165The anti-inflammatory effect of melatonin on methamphetamine-induced proinflammatory mediators in human neuroblastoma dopamine SH-SY5Y cell lines
Q28389296The complexity of the Nrf2 pathway: beyond the antioxidant response
Q35067749The effect of ex vivo CDDO-Me activation on nuclear factor erythroid 2-related factor 2 pathway in white blood cells from patients with septic shock
Q38026675The endoplasmic reticulum: a sensor of cellular stress that modulates immune responses
Q37596452The glutathione peroxidase 1-protein tyrosine phosphatase 1B-protein phosphatase 2A axis. A key determinant of airway inflammation and alveolar destruction
Q89599590The methanol extract of Guettarda speciosa Linn. Ameliorates acute lung injury in mice
Q38166575The nrf1 and nrf2 balance in oxidative stress regulation and androgen signaling in prostate cancer cells
Q34687796The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria
Q35623650The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels.
Q38867621The regulation of inflammation by oxidized phospholipids
Q46978063The role of declining adaptive homeostasis in ageing
Q39013645The role of nuclear factor-erythroid 2 related factor 2 (Nrf-2) in the protection against lung injury
Q37891127The role of oxidative stress and innate immunity in O(3) and endotoxin-induced human allergic airway disease
Q88617041The role of oxidative stress in anxiety disorder: cause or consequence?
Q34175650The synthetic triterpenoid, CDDO-Me, modulates the proinflammatory response to in vivo lipopolysaccharide challenge
Q35684749The tobacco smoke component, acrolein, suppresses innate macrophage responses by direct alkylation of c-Jun N-terminal kinase
Q49476384The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre (KC) mouse model of pancreatic cancer
Q98725936The α2 Na+/K+-ATPase isoform mediates LPS-induced neuroinflammation
Q37162845Therapeutic Effect of Chung-Pae, an Experimental Herbal Formula, on Acute Lung Inflammation Is Associated with Suppression of NF- κ B and Activation of Nrf2.
Q37101039Therapeutic Effect of the Tuber of Alisma orientale on Lipopolysaccharide-Induced Acute Lung Injury
Q90893987Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
Q34122340Toxic effects of maternal zearalenone exposure on intestinal oxidative stress, barrier function, immunological and morphological changes in rats
Q42165757Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice
Q42514932Transcriptional Regulation by Nrf2.
Q36796876Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.
Q38805723TrxR1 inhibition overcomes both hypoxia-induced and acquired bortezomib resistance in multiple myeloma through NF-кβ inhibition.
Q39123548Unravelling the networks dictating host resistance versus tolerance during pulmonary infections.
Q95856528Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases
Q36769694Update in critical care 2006.
Q50180900Violet/blue light activates Nrf2 signaling and modulates the inflammatory response of THP-1 monocytes
Q43781810Water-soluble phenol TS-13 combats acute but not chronic inflammation
Q28384223When NRF2 talks, who's listening?
Q36070027Whole-Body In Vivo Monitoring of Inflammatory Diseases Exploiting Human Interleukin 6-Luciferase Transgenic Mice
Q80133280[Clinical use of diagnostic laboratory tests in childhood sepsis]
Q91785228miR‑148 family members are putative biomarkers for sepsis
Q92366410miR‑195 promotes LPS‑mediated intestinal epithelial cell apoptosis via targeting SIRT1/eIF2a
Q90448213p-Coumaric acid protects cardiac function against lipopolysaccharide-induced acute lung injury by attenuation of oxidative stress

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