APPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway

scientific article published on October 26, 2010

APPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPENDO.00427.2010
P953full work available at URLhttp://intl-ajpendo.physiology.org/cgi/content/abstract/300/1/E103
https://europepmc.org/articles/pmc3023211
https://europepmc.org/articles/PMC3023211
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20978232/?tool=EBI
https://doi.org/10.1152/ajpendo.00427.2010
https://www.physiology.org/doi/pdf/10.1152/ajpendo.00427.2010
P932PMC publication ID3023211
P698PubMed publication ID20978232
P5875ResearchGate publication ID47556069

P2093author name stringFeng Liu
Lijun Zhou
Xiaoban Xin
Lily Q. Dong
Caleb M. Reyes
P2860cites workIdentification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2Q22010548
Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinaseQ24291657
Cloning of adiponectin receptors that mediate antidiabetic metabolic effectsQ24304889
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinaseQ24309462
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and functionQ24318702
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3Q24320233
The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivityQ24554361
Resveratrol Inhibits mTOR Signaling by Promoting the Interaction between mTOR and DEPTORQ24608321
Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinasesQ28248110
Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent mannerQ28578147
Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinaseQ28589256
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndromeQ29619211
p38 mitogen-activated protein kinase: a critical node linking insulin resistance and cardiovascular diseases in type 2 diabetes mellitusQ30447995
AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.Q32043995
Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cellsQ33553662
Transforming growth factor-beta-activated kinase 1 is an essential regulator of myogenic differentiationQ33673668
The p38 signal transduction pathway: activation and functionQ33838955
Cdo interacts with APPL1 and activates Akt in myoblast differentiationQ33992551
Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse modelsQ35053059
Exercise-induced mitogen-activated protein kinase signalling in skeletal muscleQ35855921
Dissociation of AMP-activated protein kinase and p38 mitogen-activated protein kinase signaling in skeletal muscleQ36088919
Adiponectin as an anti-inflammatory factorQ36753830
APPL1: role in adiponectin signaling and beyondQ37086421
Adiponectin and its role in cardiovascular diseasesQ37108345
Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathwaysQ37372305
Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle.Q39104985
Inhibition of p38 MAPK activation via induction of MKP-1: atrial natriuretic peptide reduces TNF-alpha-induced actin polymerization and endothelial permeabilityQ43978629
AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heartQ46716866
TAK1-mediated stress signaling pathways are essential for TNF-alpha-promoted pulmonary metastasis of murine colon cancer cells.Q53642487
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectMAP kinase signaling systemQ71130435
P304page(s)E103-10
P577publication date2010-10-26
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleAPPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway
P478volume300

Reverse relations

cites work (P2860)
Q28943417A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease
Q27310922APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments
Q35234727APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor
Q47845157APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction.
Q37628513Adipokines and the female reproductive tract
Q89313886Adipokines expression profile in liver, adipose tissue and muscle during chicken embryo development
Q39933469Adiponectin Promotes Human Jaw Bone Marrow Stem Cell Osteogenesis
Q35971216Adiponectin action: a combination of endocrine and autocrine/paracrine effects.
Q44786548Adiponectin decreases lipids deposition by p38 MAPK/ATF2 signaling pathway in muscle of broilers
Q35032468Adiponectin impairs chicken preadipocytes differentiation through p38 MAPK/ATF-2 and TOR/p70 S6 kinase pathways
Q35976593Adiponectin increases skeletal muscle mitochondrial biogenesis by suppressing mitogen-activated protein kinase phosphatase-1.
Q37670103Adiponectin inhibits insulin function in primary trophoblasts by PPARα-mediated ceramide synthesis.
Q40713483Adiponectin is required for cardiac MEF2 activation during pressure overload induced hypertrophy
Q34824199Adiponectin receptor 1 C-terminus interacts with PDZ-domain proteins such as syntrophins
Q26753354Adiponectin signaling and function in insulin target tissues
Q30313201Adiponectin stimulates lipid metabolism via AMPK in rabbit blastocysts
Q33839167Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction
Q26827971Adiponectin, driver or passenger on the road to insulin sensitivity?
Q40661957Distinct Roles for APPL1 and APPL2 in Regulating Toll-like Receptor 4 Signaling in Macrophages
Q38026339Endosomal crosstalk: meeting points for signaling pathways.
Q47138440Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms
Q42800188Mark4 promotes adipogenesis and triggers apoptosis in 3T3-L1 adipocytes by activating JNK1 and inhibiting p38MAPK pathways
Q37597694Metabolic function of the CTRP family of hormones.
Q34406365Metabolic influences on reproduction: adiponectin attenuates GnRH neuronal activity in female mice
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Q36122184Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytes
Q46210084Recombinant globular adiponectin inhibits lipid deposition by p38 MAPK/ATF-2 and TOR/p70 S6 kinase pathways in chicken adipocytes
Q35642868Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling
Q38177920Regulation of adiponectin multimerization, signaling and function
Q63408236Retrograde transport of Akt by a neuronal Rab5-APPL1 endosome
Q26766002Signal processing by the endosomal system
Q90145983mTOR activation due to APPL1 deficiency exacerbates hyperalgesia via Rab5/Akt and AMPK signaling pathway in streptozocin-induced diabetic rats
Q41241233p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development

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