Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease

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Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NM804
P698PubMed publication ID12461524
P5875ResearchGate publication ID11008478

P50authorWillem van EdenQ62042571
Peter ThomasQ104733731
P2093author name stringMatthias Mack
Ulrich Mrowietz
Martin Dugas
Christian A Sander
Ruurd van der Zee
Detlef Schlöndorff
Martin Röcken
Enno Christophers
Gerd Plewig
Kamran Ghoreschi
Tilo Biedermann
Reinhard Mailhammer
Jörg Prinz
Susanne Breit
P2860cites workInterleukin-10 and the interleukin-10 receptorQ24290912
The IL-4 receptor: signaling mechanisms and biologic functionsQ28198739
Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trialQ28202251
The interleukin-10 family of cytokinesQ28212212
Interleukin 20: discovery, receptor identification, and role in epidermal functionQ28593930
Functional diversity of helper T lymphocytesQ29619415
Inflammatory skin diseases, T cells, and immune surveillanceQ33788959
Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesionsQ33902313
Tolerance and autoimmunityQ34167913
Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokinesQ34234920
The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiatQ34505900
Injection of pre-psoriatic skin with CD4+ T cells induces psoriasisQ35787223
Interleukin (IL) 4 differentially regulates monocyte IL-1 family gene expression and synthesis in vitro and in vivoQ36361487
Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivoQ36363260
Cytokine-induced immune deviation as a therapy for inflammatory autoimmune diseaseQ36364080
Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2.Q36368565
Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cellsQ36368842
Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infectionQ39200565
Lymphocyte responses and cytokinesQ40620203
Lymphokine production by human T cells in disease statesQ40661109
IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune diseaseQ41305674
Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell levelQ42114901
Response of psoriasis to interleukin-10 is associated with suppression of cutaneous type 1 inflammation, downregulation of the epidermal interleukin-8/CXCR2 pathway and normalization of keratinocyte maturation.Q42642368
Reversal of established delayed type hypersensitivity reactions following therapy with IL-4 or antigen-specific Th2 cellsQ43682661
Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes.Q52018451
Effects of systemic interleukin-10 therapy on psoriatic skin lesions: histologic, immunohistologic, and molecular biology findings.Q52964524
Safety evaluation of recombinant human interleukin-4. II. Clinical studies.Q54568796
Induction of a non-encephalitogenic type 2 T helper-cell autoimmune responsein multiple sclerosis after administration of an altered peptide ligand ina placebo-controlled, randomized phase II trialQ57911995
CCR5 is characteristic of Th1 lymphocytesQ59092711
IL-4 Is a Mediator of IL-12p70 Induction by Human Th2 Cells: Reversal of Polarized Th2 Phenotype by Dendritic CellsQ62589132
A strict requirement of interleukin-4 for interleukin-4 induction in antigen-stimulated human memory T cellsQ71420944
Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basisQ71803269
Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligandQ73035541
Selection of conserved TCR VDJ rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgarisQ73129277
Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivoQ73281771
Regulation of angiogenesis by the C-X-C chemokines interleukin-8 and epithelial neutrophil activating peptide 78 in the rheumatoid jointQ73521731
Psoralen bath plus UV-A therapy. Possibilities and limitationsQ74010742
New treatments for psoriasisQ74271067
IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c miceQ74619595
Cyclosporine consensus conference: with emphasis on the treatment of psoriasisQ77303806
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectinterleukinsQ194908
autoimmune diseaseQ8084905
P304page(s)40-46
P577publication date2002-12-02
P1433published inNature MedicineQ1633234
P1476titleInterleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease
P478volume9