The future prospects of pharmacogenetics in oral anticoagulation therapy

scientific article

The future prospects of pharmacogenetics in oral anticoagulation therapy is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1111/J.1365-2125.2006.02679.X
P932PMC publication ID1885126
P698PubMed publication ID16722840
P5875ResearchGate publication ID7059682

P50authorMunir PirmohamedQ20127995
P2093author name stringFarhad Kamali
P2860cites workCytochrome P4502C9: an enzyme of major importance in human drug metabolismQ24683497
CYP2C9 allelic variants: ethnic distribution and functional significanceQ28212029
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2Q28242581
Identification of the gene for vitamin K epoxide reductaseQ28242592
Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors.Q34283903
The influence of age, liver size and enantiomer concentrations on warfarin requirementsQ34347371
Common VKORC1 and GGCX polymorphisms associated with warfarin doseQ34417386
A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity.Q34418092
Effect of VKORC1 haplotypes on transcriptional regulation and warfarin doseQ34423204
Flexible induction dose regimen for warfarin and prediction of maintenance doseQ34548246
The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphismQ34735686
Risk factors for bleeding in patients taking coumarins.Q35193074
Evaluation of the pattern of treatment, level of anticoagulation control, and outcome of treatment with warfarin in patients with non-valvar atrial fibrillation: a record linkage study in a large British populationQ35583944
Frequency of cytochrome P450 2C9 mutant alleles in a Korean populationQ36055401
Factors affecting the maintenance dose of warfarinQ37110242
Effect of age upon the induction and maintenance of anticoagulation with warfarin.Q38639783
Ethnic differences in CYP2C9*2 (Arg144Cys) and CYP2C9*3 (Ile359Leu) genotypes in Japanese and Israeli populationsQ39194380
Aging and the anticoagulant response to warfarin therapyQ43672961
Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African AmericansQ43675710
Patient-specific factors predictive of warfarin dosage requirementsQ44146616
Population differences in S-warfarin metabolism between CYP2C9 genotype-matched Caucasian and Japanese patientsQ44351201
Racial background is a determinant factor in the maintenance dosage of warfarin.Q44534843
Warfarin dose adjustments based on CYP2C9 genetic polymorphismsQ44546032
Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomised controlled trialQ44672192
Association of pharmacokinetic (CYP2C9) and pharmacodynamic (factors II, VII, IX, and X; proteins S and C; and gamma-glutamyl carboxylase) gene variants with warfarin sensitivityQ44680862
Dietary vitamin K influences intra-individual variability in anticoagulant response to warfarinQ44724648
Contribution of age, body size, and CYP2C9 genotype to anticoagulant response to warfarinQ44787224
A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin.Q45052744
Novel CYP2C9 genetic variants in Asian subjects and their influence on maintenance warfarin doseQ45062168
The influence of ethnicity on warfarin dosage requirementQ46458606
The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimenQ46537717
Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast AsiansQ46650072
Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populationsQ46696260
Genetic polymorphism of cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese populationQ47957665
Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypesQ47961549
Factors determining the maintenance dose of warfarin in Chinese patients.Q51020114
Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment.Q52106400
Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.Q52550127
Prospective study of the outcomes of ambulatory patients with excessive warfarin anticoagulation.Q53335803
The influence of (R)- and (S)-warfarin, vitamin K and vitamin K epoxide upon warfarin anticoagulation.Q54041860
VKORCI haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulationQ58273734
Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complicationsQ63241969
Prospective evaluation of a flexible protocol for starting treatment with warfarin and predicting its maintenance doseQ69717081
Bleeding during antithrombotic therapy in patients with atrial fibrillation. The Stroke Prevention in Atrial Fibrillation InvestigatorsQ71016449
The risk for and severity of bleeding complications in elderly patients treated with warfarin. The National Consortium of Anticoagulation ClinicsQ71064706
Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9Q71996232
Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trialsQ72030226
Detection of CYP2C9 polymorphism based on the polymerase chain reaction in ChineseQ72293605
Effect of long-term oral anticoagulant treatment on mortality and cardiovascular morbidity after myocardial infarction. Anticoagulants in the Secondary Prevention of Events in Coronary Thrombosis (ASPECT) Research GroupQ72669442
Prospective evaluation of a modified Fennerty regimen for anticoagulating elderly peopleQ73214217
Initiating and Maintaining Patients on Warfarin Anticoagulation: The Importance of MonitoringQ73468973
Anticoagulation of older patients: a need to modify current practiceQ73470048
Vitamin K intake and sensitivity to warfarin in patients consuming regular dietsQ74671072
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectanticoagulationQ63279445
P304page(s)746-751
P577publication date2006-06-01
P1433published inBritish Journal of Clinical PharmacologyQ176044
P1476titleThe future prospects of pharmacogenetics in oral anticoagulation therapy
P478volume61

Reverse relations

cites work (P2860)
Q36729204A pilot study of the association of pharmacokinetic and pharmacodynamic parameters of warfarin with the dose in patients on long-term anticoagulation
Q36855608Cytochrome P450 (CYP2C9*2,*3) & vitamin-K epoxide reductase complex (VKORC1 -1639G
Q42707554Effect of CYP2C9 and VKORC1 genetic variations on warfarin dose requirements in Indian patients
Q36921008Exposure to non-therapeutic INR in a high risk cardiovascular patient: potential hazard reduction with genotype-guided warfarin (Coumadin) dosing
Q33990428Implementing genotype-guided antithrombotic therapy
Q36965475Integrating genomic based information into clinical warfarin (Coumadin) management: an illustrative case report.
Q36898747Predict, prevent and personalize: Genomic and proteomic approaches to cardiovascular medicine
Q36044022Prediction of warfarin dose reductions in Puerto Rican patients, based on combinatorial CYP2C9 and VKORC1 genotypes
Q33990441Prevalence of combinatorial CYP2C9 and VKORC1 genotypes in Puerto Ricans: implications for warfarin management in Hispanics.
Q34494596Prevalence of genetic variants associated with cardiovascular disease risk and drug response in the Southern Indian population of Kerala.
Q50348713Prospective pilot trial of PerMIT versus standard anticoagulation service management of patients initiating oral anticoagulation.
Q37517041Should all anticoagulated patients with head injury receive a CT scan? Decision-analysis modelling of an observational cohort.
Q37160370Should we test for CYP2C9 before initiating anticoagulant therapy in patients with atrial fibrillation?
Q38120951The changing face of oral anticoagulants
Q37082703The new biology: a bridge to clinical cardiology
Q41968877VKORC1 pharmacogenomics summary
Q83527915Warfarin-induced skin necrosis
Q24678632Warfarin: almost 60 years old and still causing problems

Search more.