Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae

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Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae is …
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scholarly articleQ13442814

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P356DOI10.1128/IAI.71.1.75-85.2003
P932PMC publication ID143380
P698PubMed publication ID12496151
P5875ResearchGate publication ID10978994

P50authorDavid E. BrilesQ112394397
Alexander J. SzalaiQ42706107
P2093author name stringBing Ren
Susan K Hollingshead
Orlanda Thomas
P2860cites workActivation of the classical pathway of complement by binding of bovine lactoferrin to unencapsulated Streptococcus agalactiaeQ70497339
Modulation of classical C3 convertase of complement by tear lactoferrinQ71957594
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C3 as substrate for adhesion of Streptococcus pneumoniaeQ74068770
Surface expression of lactoferrin by resting neutrophilsQ74177605
Antibacterial effects of lactoferricin BQ78125935
Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniaeQ22065841
Pneumolysin is the main inducer of cytotoxicity to brain microvascular endothelial cells caused by Streptococcus pneumoniaeQ24548716
Localization of protection-eliciting epitopes on PspA of Streptococcus pneumoniae between amino acid residues 192 and 260.Q30418186
Novel purification scheme and functions for a C3-binding protein from Streptococcus pneumoniaeQ30872436
Clinical isolates of Streptococcus pneumoniae that exhibit tolerance of vancomycinQ31954126
PspA, a surface protein of Streptococcus pneumoniae, is capable of eliciting protection against pneumococci of more than one capsular typeQ33513623
Role of novel choline binding proteins in virulence of Streptococcus pneumoniaeQ33591905
Diversity of PspA: mosaic genes and evidence for past recombination in Streptococcus pneumoniaeQ33592652
Lactoferrin: a multifunctional glycoproteinQ33794833
Identification of pneumococcal surface protein A as a lactoferrin-binding protein of Streptococcus pneumoniaeQ34000817
Pneumococcal surface protein A inhibits complement activation by Streptococcus pneumoniae.Q34001813
The pspC gene of Streptococcus pneumoniae encodes a polymorphic protein, PspC, which elicits cross-reactive antibodies to PspA and provides immunity to pneumococcal bacteremiaQ34002787
Characterization of binding of human lactoferrin to pneumococcal surface protein AQ34007403
Pneumococcal surface protein A (PspA) is serologically highly variable and is expressed by all clinically important capsular serotypes of Streptococcus pneumoniaeQ35105898
Infections caused by Streptococcus pneumoniae: clinical spectrum, pathogenesis, immunity, and treatmentQ36068673
Novel surface attachment mechanism of the Streptococcus pneumoniae protein PspAQ36107664
Structural properties and evolutionary relationships of PspA, a surface protein of Streptococcus pneumoniae, as revealed by sequence analysisQ36109895
Truncated forms of PspA that are secreted from Streptococcus pneumoniae and their use in functional studies and cloning of the pspA geneQ36109903
Use of insertional inactivation to facilitate studies of biological properties of pneumococcal surface protein A (PspA).Q36353317
Resistance to both complement activation and phagocytosis in type 3 pneumococci is mediated by the binding of complement regulatory protein factor H.Q39511742
Comparison of the PspA sequence from Streptococcus pneumoniae EF5668 to the previously identified PspA sequence from strain Rx1 and ability of PspA from EF5668 to elicit protection against pneumococci of different capsular typesQ39573167
A Bactericidal Effect for Human LactoferrinQ40784798
Role of pneumococcal surface protein A in the virulence of Streptococcus pneumoniae.Q41274022
PspA and PspC: their potential for use as pneumococcal vaccinesQ41689107
Pneumococcal surface protein A of invasive Streptococcus pneumoniae isolates from Colombian childrenQ41761101
Inhibition of C3 deposition on solid-phase bound immune complexes by lactoferrinQ69812054
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectStreptococcus pneumoniaeQ221179
P304page(s)75-85
P577publication date2003-01-01
P1433published inInfection and ImmunityQ6029193
P1476titleBoth family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae
P478volume71