The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia

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The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia is …
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scholarly articleQ13442814

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P356DOI10.1016/J.NEUROPHARM.2016.07.004
P932PMC publication ID4981430
P698PubMed publication ID27392635

P50authorHanns Ulrich ZeilhoferQ42870793
P2093author name stringUwe Rudolph
William T Ralvenius
Dietmar Benke
Youssef Daali
Jules Desmeules
Marie Besson
Alain Matthey
Mario A Acuña
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Serum and cerebrospinal fluid concentration of clobazam and N-desmethylclobazamQ72586061
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TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.Q34453763
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P304page(s)366-375
P577publication date2016-07-05
P1433published inNeuropharmacologyQ15332439
P1476titleThe clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia
P478volume109