Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas

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Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas is …
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scholarly articleQ13442814

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P819ADS bibcode2011PNAS..108.1439L
P356DOI10.1073/PNAS.1012500108
P932PMC publication ID3029686
P698PubMed publication ID21220347
P5875ResearchGate publication ID49741945

P50authorAndrew B. WestQ37378096
Thomas GiordanoQ37621567
Bin Tean TehQ47451223
Jeffrey P MacKeiganQ57321283
Brendan D LooyengaQ64513884
P2093author name stringKarl J Dykema
Kyle A Furge
James H Resau
Pamela J Swiatek
Julie Koeman
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The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuitQ72560868
Characterization of a new animal model for human renal cell carcinomaQ74031617
Genomic imbalances in 61 renal cancers from the proximal tubulus detected by comparative genomic hybridizationQ74440655
Significance of trisomy 7 and 12 in thyroid lesions with follicular differentiation: a cytogenetic and in situ hybridization studyQ77352909
Comparative genomic hybridization, BRAF, RAS, RET, and oligo-array analysis in aneuploid papillary thyroid carcinomasQ81040981
Identification of copy number alterations and its association with pathological features in clear cell and papillary RCCQ81746525
Classification of renal neoplasms based on molecular signaturesQ83335203
Exploration, normalization, and summaries of high density oligonucleotide array probe level dataQ27861098
Oncogenic kinase signallingQ28189493
Met, metastasis, motility and moreQ28235183
Autophagic cell death: the story of a misnomerQ29614564
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Epidermal growth factor receptor mutations in lung cancerQ29615474
Detection of DNA copy number changes and oncogenic signaling abnormalities from gene expression data reveals MYC activation in high-grade papillary renal cell carcinomaQ31108141
How aneuploidy may cause cancer and genetic instabilityQ33851935
LRRK2 G2019S mutations are associated with an increased cancer risk in Parkinson diseaseQ34299954
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.Q34307548
Papillary renal cell carcinoma: analysis of germline mutations in the MET proto-oncogene in a clinic-based populationQ34364668
A molecular classification of papillary renal cell carcinomaQ34558981
Identification of genes differentially expressed in benign versus malignant thyroid tumorsQ34913566
Detection of numerical alterations for chromosomes 7 and 12 in benign thyroid lesions by in situ hybridization. Histological implicationsQ35796348
Cancer therapy: can the challenge be MET?Q36159458
Activating mutations for the met tyrosine kinase receptor in human cancerQ36595980
Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation.Q36860354
Met and hepatocyte growth factor/scatter factor expression in human gliomasQ36894692
Aberrant receptor signaling and trafficking as mechanisms in oncogenesisQ36979383
Targeting MET as a strategy to overcome crosstalk-related resistance to EGFR inhibitorsQ37539304
Biological significance of c-met over expression in papillary renal cell carcinomaQ38456509
Mapping of the 7q31 subregion common to the small chromosome 7 derivatives from two sporadic papillary renal cell carcinomas: increased copy number and overexpression of the MET proto-oncogeneQ38497635
Endosomal dynamics of Met determine signaling outputQ39745537
Growth factor independence and growth regulatory pathways in human melanoma developmentQ40801225
HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidneyQ41499933
Novel mutations of the MET proto-oncogene in papillary renal carcinomas.Q42815807
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomasQ45345804
Molecular cloning of a new transforming gene from a chemically transformed human cell line.Q45345810
Cytogenetic and morphologic typing of 58 papillary renal cell carcinomas: evidence for a cytogenetic evolution of type 2 from type 1 tumorsQ56976288
Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysisQ58053853
P4510describes a project that useslimmaQ112236343
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1439-1444
P577publication date2011-01-10
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleChromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas
P478volume108

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