Lack of avidity maturation of merozoite antigen-specific antibodies with increasing exposure to Plasmodium falciparum amongst children and adults exposed to endemic malaria in Kenya

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Lack of avidity maturation of merozoite antigen-specific antibodies with increasing exposure to Plasmodium falciparum amongst children and adults exposed to endemic malaria in Kenya is …
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scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...752939I
P356DOI10.1371/JOURNAL.PONE.0052939
P932PMC publication ID3530478
P698PubMed publication ID23300828
P5875ResearchGate publication ID234090428

P50authorPhilip BejonQ28955486
Francis M. NdunguQ55174885
Ally OlotuQ96759350
Kevin MarshQ30102986
P2093author name stringEric Ohuma
Daniel M Muema
Jedida Mwacharo
Domtila Kimani
Frances Ibison
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Recent primary toxoplasma infection indicated by a low avidity of specific IgGQ69965647
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Fatal Plasmodium falciparum malaria causes specific patterns of splenic architectural disorganizationQ33769238
Antibody avidity and immunoglobulin G isotype distribution following immunization with a monovalent meningococcal B outer membrane vesicle vaccineQ34118124
High affinity antibodies to Plasmodium falciparum merozoite antigens are associated with protection from malariaQ34171724
Estimating individual exposure to malaria using local prevalence of malaria infection in the fieldQ34221250
Memory B cells are a more reliable archive for historical antimalarial responses than plasma antibodies in no-longer exposed childrenQ34261333
Target antigen, age, and duration of antigen exposure independently regulate immunoglobulin G subclass switching in malariaQ34301187
High avidity antibodies to full-length VAR2CSA correlate with absence of placental malariaQ34326742
Humoral immune response to primary rubella virus infectionQ34429454
The decline in paediatric malaria admissions on the coast of KenyaQ36372814
Clinical algorithms for malaria diagnosis lack utility among people of different age groupsQ36463318
Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malariaQ36594057
Alterations of splenic architecture in malaria are induced independently of Toll-like receptors 2, 4, and 9 or MyD88 and may affect antibody affinityQ36845116
Pattern of humoral immune response to Plasmodium falciparum blood stages in individuals presenting different clinical expressions of malariaQ36919828
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Serology: a robust indicator of malaria transmission intensity?Q36995780
The impact of primary health care on malaria morbidity--defining access by disease burdenQ37135862
The induction and persistence of T cell IFN-gamma responses after vaccination or natural exposure is suppressed by Plasmodium falciparumQ37135865
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How might infant and paediatric immune responses influence malaria vaccine efficacy?Q37382587
Case definitions of clinical malaria under different transmission conditions in Kilifi District, KenyaQ39130334
Plasmodium falciparum merozoite surface protein 3 is a target of allele-specific immunity and alleles are maintained by natural selectionQ39362543
High levels of serum antibodies to merozoite surface protein 2 of Plasmodium falciparum are associated with reduced risk of clinical malaria in coastal KenyaQ39362550
Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malariaQ39362569
Parasitologic and clinical human response to immunoglobulin administration in falciparum malaria.Q39417737
Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stagesQ41835030
Plasmodium chabaudi chabaudi infection in mice induces strong B cell responses and striking but temporary changes in splenic cell distributionQ43751346
Mechanisms of splenic control of murine malaria: cellular reactions of the spleen in lethal (strain 17XL) Plasmodium yoelii malaria in BALB/c mice, and the consequences of pre-infective splenectomy.Q43787492
Spatial and temporal heterogeneity of Anopheles mosquitoes and Plasmodium falciparum transmission along the Kenyan coastQ44151640
The isotype composition and avidity of naturally acquired anti-Plasmodium falciparum antibodies: differential patterns in clinically immune Africans and Amazonian patientsQ46688697
Malaria-specific antibody responses and parasite persistence after infection of mice with Plasmodium chabaudi chabaudiQ47841563
Histological changes in the spleen and liver of C57BL/6 and A/J mice during Plasmodium chabaudi AS infectionQ47898495
Gamma-globulin and acquired immunity to human malariaQ47957467
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectKenyaQ114
antibodyQ79460
malariaQ12156
Plasmodium falciparumQ311383
merozoiteQ2296434
P304page(s)e52939
P577publication date2012-12-26
P1433published inPLOS OneQ564954
P1476titleLack of avidity maturation of merozoite antigen-specific antibodies with increasing exposure to Plasmodium falciparum amongst children and adults exposed to endemic malaria in Kenya
P478volume7