Aripiprazole: a comprehensive review of its pharmacology, clinical efficacy, and tolerability

scientific article

Aripiprazole: a comprehensive review of its pharmacology, clinical efficacy, and tolerability is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0149-2918(04)90066-5
P698PubMed publication ID15220010

P50authorM. Lynn CrismonQ111749060
P2093author name stringNick C Patel
Anthony DeLeon
P2860cites workDopamine system stabilizers, aripiprazole, and the next generation of antipsychotics, part 1, "Goldilocks" actions at dopamine receptors.Q43844457
Dopamine system stabilizers, aripiprazole, and the next generation of antipsychotics, part 2: illustrating their mechanism of action.Q43847484
Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptorsQ44028935
Striatal dopamine-2 receptor occupancy as measured with [123I]iodobenzamide and SPECT predicted the occurrence of EPS in patients treated with atypical antipsychotics and haloperidolQ44055480
Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder.Q44167467
Aripiprazole: does partial dopaminergic agonism translate into clinical benefits?Q44412619
Aripiprazole in the treatment of schizophrenia: safety and tolerability in short-term, placebo-controlled trialsQ44428863
Aripiprazole, an antipsychotic with a novel mechanism of action, and risperidone vs placebo in patients with schizophrenia and schizoaffective disorderQ44513113
A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar maniaQ44565868
Efficacy and safety of aripiprazole vs. haloperidol for long-term maintenance treatment following acute relapse of schizophreniaQ44649979
Aripiprazole for the prevention of relapse in stabilized patients with chronic schizophrenia: a placebo-controlled 26-week study.Q44662788
Inhibition by aripiprazole of dopaminergic inputs to striatal neurons from substantia nigraQ48088371
Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: role of 5HT2 receptorsQ48392880
Inhibition by a putative antipsychotic quinolinone derivative (OPC-14597) of dopaminergic neurons in the ventral tegmental areaQ48940484
Radioreceptor binding profile of the atypical antipsychotic olanzapineQ49130929
Behavioural and neurochemical effects of OPC-14597, a novel antipsychotic drug, on dopaminergic mechanisms in rat brainQ70812948
SchizophreniaQ79226206
Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effectsQ28327576
Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypesQ28375923
A double-blind pilot study of risperidone in the treatment of conduct disorderQ28376547
Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesisQ32068772
Switching patients to aripiprazole from other antipsychotic agents: a multicenter randomized studyQ33186211
The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptorQ33959664
Dopamine D2 and D3 receptor occupancy in normal humans treated with the antipsychotic drug aripiprazole (OPC 14597): a study using positron emission tomography and [11C]racloprideQ33959951
Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophreniaQ34507860
Partial dopamine agonists in the treatment of psychosisQ34603506
The neurobiology and control of anxious statesQ35202929
Mechanism of new antipsychotic medications: occupancy is not just antagonismQ35558773
Aripiprazole, a novel antipsychotic drug, inhibits quinpirole-evoked GTPase activity but does not up-regulate dopamine D2 receptor following repeated treatment in the rat striatumQ38348350
Do novel antipsychotics have similar pharmacological characteristics? A review of the evidenceQ41682564
"Hit-and-run" actions at dopamine receptors, part 1: Mechanism of action of atypical antipsychotics.Q43780540
P433issue5
P921main subjectpharmacologyQ128406
P304page(s)649-666
P577publication date2004-05-01
P1433published inClinical TherapeuticsQ15716601
P1476titleAripiprazole: a comprehensive review of its pharmacology, clinical efficacy, and tolerability
P478volume26

Reverse relations

cites work (P2860)
Q370671252-Bromoterguride-a potential atypical antipsychotic drug without metabolic effects in rats.
Q37326130A UK consensus on the administration of aripiprazole for the treatment of mania
Q46886125A case of Aripiprazole and extra pyramidal side effects
Q79212271A case series of patients with Tourette's syndrome in the United Kingdom treated with aripiprazole
Q36853249A case series: evaluation of the metabolic safety of aripiprazole
Q46170156A non-randomized study to investigate the effects of the atypical antipsychotic aripiprazole on the steady-state pharmacokinetics of lamotrigine in patients with bipolar I disorder
Q37510958A review of the safety and tolerability of aripiprazole
Q38111956A systematic review of reported cases involving psychotic symptoms worsened by aripiprazole in schizophrenia or schizoaffective disorder
Q35188726Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists
Q48512330Add-on Aripiprazole for Atypical Antipsychotic-induced, Clinically Significant Hyperprolactinemia
Q45229981Adjunctive aripiprazole for bupropion-resistant major depression
Q46055786Adjunctive aripiprazole in bipolar I depression
Q34925151Adjunctive aripiprazole versus placebo for antipsychotic-induced hyperprolactinemia: meta-analysis of randomized controlled trials
Q49472268Adsorptive stripping voltammetric methods for determination of aripiprazole
Q24649568Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia
Q37959135An open trial of aripiprazole for the treatment of delirium in hospitalized cancer patients
Q34642676An open-label, rater-blinded, augmentation study of aripiprazole in treatment-resistant depression
Q36062184An update of safety of clinically used atypical antipsychotics
Q38830416Antipsychotic drugs in Huntington's disease.
Q33755676Antipsychotic treatments for the elderly: efficacy and safety of aripiprazole
Q42975239Aripiprazole - a medical treatment alternative for Tourette Syndrome in childhood and adolescence
Q33650040Aripiprazole Facilitates Extinction of Conditioned Fear in Adolescent Rats.
Q47895142Aripiprazole Suppression of Drinking in a Clinical Laboratory Paradigm: Influence of Impulsivity and Self-Control.
Q46446352Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors
Q36846918Aripiprazole and Haloperidol Activate GSK3β-Dependent Signalling Pathway Differentially in Various Brain Regions of Rats
Q33799660Aripiprazole as adjunctive therapy for patients with major depressive disorder: overview and implications of clinical trial data
Q44735526Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice.
Q46128379Aripiprazole differentially affects mesolimbic and nigrostriatal dopaminergic transmission: implications for long-term drug efficacy and low extrapyramidal side-effects
Q34013720Aripiprazole effects on alcohol consumption and subjective reports in a clinical laboratory paradigm--possible influence of self-control
Q35015469Aripiprazole for the maintenance treatment of bipolar disorder: a review of available evidence
Q36405102Aripiprazole for the treatment of Tourette's disorder
Q37831357Aripiprazole for the treatment of bipolar disorder: a review of current evidence
Q37835845Aripiprazole for the treatment of irritability associated with autism
Q64114058Aripiprazole for the treatment of psychotic symptoms in patients with dementia with Lewy bodies: a case series
Q46208591Aripiprazole in anorexia nervosa and low-weight bulimia nervosa: case reports
Q34605438Aripiprazole in schizotypal personality disorder: a case report
Q37133284Aripiprazole in the treatment of depressive and anxiety disorders: a review of current evidence
Q41982065Aripiprazole therapy for nicotine dependence
Q37947687Aripiprazole treatment for patients with schizophrenia: from acute treatment to maintenance treatment
Q43024905Aripiprazole worsens psychosis: a case report
Q39244947Aripiprazole, a Drug that Displays Partial Agonism and Functional Selectivity
Q36808054Aripiprazole: pharmacology and evidence in bipolar disorder
Q34558285Aripiprazole: pharmacology, efficacy, safety and tolerability
Q36584260Atypical antipsychotics in the treatment of depressive and psychotic symptoms in patients with chronic schizophrenia: a naturalistic study
Q27311205Blonanserin ameliorates phencyclidine-induced visual-recognition memory deficits: the complex mechanism of blonanserin action involving D₃-5-HT₂A and D₁-NMDA receptors in the mPFC.
Q37111054Chronic administration of aripiprazole activates GSK3β-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats
Q89145780Clinical Pharmacokinetics of Atypical Antipsychotics: An Update
Q36804367Clinical pharmacokinetics of atypical antipsychotics: a critical review of the relationship between plasma concentrations and clinical response
Q35728228Clinical pharmacology of atypical antipsychotics: an update.
Q34529810Comparison the effectiveness of aripiprazole and risperidone for the treatment of acute bipolar mania
Q33925658Delirium in advanced age and dementia: A prolonged refractory course of delirium and lower functional status.
Q41433244Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands
Q37025888Development of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficits
Q99566745Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia
Q34660695Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens
Q37714573Dosing and switching of paliperidone ER in patients with schizophrenia: recommendations for clinical practice
Q38207705Drugs currently in Phase II clinical trials for cocaine addiction
Q55431729Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors.
Q40921574Effect of combination of aripiprazole with carbamazepine and fluvoxamine on liver functions in experimental animals
Q57526943Effectiveness Study of Venlafaxine-XR Combined with Aripiprazole for Chronic or Recurrent Major Depressive Disorder
Q51526215Effects of amisulpride and aripiprazole on progressive-ratio schedule performance: comparison with clozapine and haloperidol.
Q47207523Effects of aripiprazole augmentation in treatment-resistant obsessive-compulsive disorder (a double blind clinical trial).
Q34009852Effects of aripiprazole on subjective and physiological responses to alcohol
Q46927168Effects of aripiprazole, olanzapine, and haloperidol in a model of cognitive deficit of schizophrenia in rats: relationship with glutamate release in the medial prefrontal cortex
Q37299210Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review
Q33695789Efficacy of Atypical Antipsychotics in the Management of Acute Agitation and Aggression in Hospitalized Patients with Schizophrenia or Bipolar Disorder: Results from a Systematic Review
Q33518314Evaluation of akathisia in patients with schizophrenia, schizoaffective disorder, or bipolar I disorder: a post hoc analysis of pooled data from short- and long-term aripiprazole trials
Q36588607Evidence review and clinical guidance for the use of ziprasidone in Canada
Q36133796First-episode schizophrenia: a focus on pharmacological treatment and safety considerations
Q64039164From Clinical Research to Clinical Practice: A 4-Year Review of Ziprasidone
Q28306632Gilles de la Tourette syndrome: the complexities of phenotype and treatment
Q30849611Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia
Q37948917Improvement of tardive dyskinesia and dystonia associated with aripiprazole following a switch to quetiapine: case report and review of the literature
Q39555488Impulse control loss rapidly reversed by aripiprazole in a patient with concomitant bipolar disease type I and posttraumatic frontal lobe lesions
Q48292762In vivo actions of aripiprazole on serotonergic and dopaminergic systems in rodent brain
Q34527796Incontinence and mood disorder: is there an association?
Q42290095Low-Dose Aripiprazole Augmentation in Amitriptyline-Resistant Burning Mouth Syndrome: Results from Two Cases.
Q38689883Lurasidone for the treatment of irritability and anger in autism spectrum disorders
Q37316813Management of psychosis in patients with Alzheimer's disease: focus on aripiprazole
Q41828115Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripiprazole
Q34772251New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling
Q34613057Open-label study comparing the efficacy and tolerability of aripiprazole and haloperidol in the treatment of pediatric tic disorders
Q50205908Overdoses with Aripiprazole: Signs, Symptoms and Outcome in 239 Exposures Reported to the Danish Poison Information Centre
Q41901628Palau'chlor: a practical and reactive chlorinating reagent
Q48607362Potential aripiprazole-mediated extrapyramidal symptoms in an adult with developmental disabilities
Q54119984Potentiating and synergistic effect of grapefruit juice on the antioxidant and anti-inflammatory activity of aripiprazole against hydrogen peroxide induced oxidative stress in mice.
Q40200910Predicting pharmacokinetic stability by multiple oral administration of atypical antipsychotics
Q36216477Pretreatment or Posttreatment with Aripiprazole Attenuates Methamphetamine-induced Stereotyped Behavior in Mice
Q35062881Repeated aripiprazole administration attenuates cocaine seeking in a rat model of relapse
Q28273912Role of Dopamine 2 Receptor in Impaired Drug-Cue Extinction in Adolescent Rats
Q34154951Schizophrenia: overview and treatment options
Q38125219Second-generation antipsychotics in the treatment of major depressive disorder: current evidence.
Q48943125Successful Treatment Response with Aripiprazole Augmentation of SSRIs in Refractory Obsessive-Compulsive Disorder in Childhood
Q45020983Sudden unexpected death in epilepsy associated with progressive deterioration in heart rate variability
Q64330025TARC: Turkish aripiprazole consensus report- Aripiprazole use and switching from other antipsychotics to aripiprazole- consensus recommendations by a Turkish multidisciplinary panel
Q47624983The Place of Antipsychotics in the Therapy of Anxiety Disorders and Obsessive-Compulsive Disorders.
Q36094872The art of prescribing. Principles of switching novel antipsychotic medications
Q36677469The effect of aripiprazole on cue-induced brain activation and drinking parameters in alcoholics
Q42464924The effect of dopamine partial agonists on the nicotine dependency in patients with schizophrenia
Q33619940The effects of novel and newly approved antipsychotics on serum prolactin levels: a comprehensive review.
Q42599261The pharmacokinetics of standard antidepressants with aripiprazole as adjunctive therapy: studies in healthy subjects and in patients with major depressive disorder.
Q58861808Thermal stability of aripiprazole monohydrate investigated by Raman spectroscopy
Q46057245Transition-Metal-Free Decarboxylative Iodination: New Routes for Decarboxylative Oxidative Cross-Couplings.
Q41528294Treatment and prevention of mania in bipolar I disorder: focus on aripiprazole
Q38334922Treatment of clozapine-associated weight gain: a systematic review.
Q42101428Unexpected effect of aripiprazole on nociceptive pain
Q28546441Unique Effects of Acute Aripiprazole Treatment on the Dopamine D2 Receptor Downstream cAMP-PKA and Akt-GSK3β Signalling Pathways in Rats
Q42852114Validated spectrophotometric quantification of aripiprazole in pharmaceutical formulations by using multivariate technique
Q26899110XMetDB: an open access database for xenobiotic metabolism

Search more.