The 3'-5' DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response

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The 3'-5' DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M114.547331
P932PMC publication ID4239609
P698PubMed publication ID25278026

P50authorHerbert C. MorseQ37375260
P2093author name stringTeruhiko Suzuki
Hongsheng Wang
Yong-Soo Kim
Takuya Miyazaki
Jeongheon Yoon
P2860cites workNucleic acid recognition by the innate immune systemQ37827142
New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPsQ38020082
c-MYC suppresses BIN1 to release poly(ADP-ribose) polymerase 1: a mechanism by which cancer cells acquire cisplatin resistanceQ39568637
Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damageQ39698684
A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activationQ39773986
BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cellsQ39833724
C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophyQ40101085
A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupusQ40144366
A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage.Q41024739
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.Q50671884
SET and PARP1 remove DEK from chromatin to permit access by the transcription machineryQ80387209
Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleasesQ22010206
A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD proteinQ22010212
Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteinsQ24291054
XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damageQ24522502
Trex1 prevents cell-intrinsic initiation of autoimmunityQ24648757
Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW DomainsQ27644048
Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1Q27679074
The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaksQ27681059
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitorQ28182042
The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell deathQ28250070
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ationQ28250296
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locusQ28252435
Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responsesQ28303382
PARP inhibition: PARP1 and beyondQ29619617
New roles for the major human 3'-5' exonuclease TREX1 in human diseaseQ33671295
SIRT6 promotes DNA repair under stress by activating PARP1Q33803766
Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?Q33944812
The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1Q34140181
Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genesQ34312364
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune diseaseQ34719398
Evaluation of the TREX1 gene in a large multi-ancestral lupus cohortQ35022304
Familial chilblain lupus, a monogenic form of cutaneous lupus erythematosus, maps to chromosome 3p.Q35070451
A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partnersQ35131459
Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditisQ35663520
Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndromeQ35752487
Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding proteinQ36227838
TREX1 acts in degrading damaged DNA from drug-treated tumor cellsQ36807245
The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1.Q37295146
P4510describes a project that usesImageJQ1659584
P433issue47
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
P1104number of pages11
P304page(s)32548-32558
P577publication date2014-10-02
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe 3'-5' DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response
P478volume289