Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients.

scholarly article

Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2006PNAS..103.7000H
P356DOI10.1073/PNAS.0600363103
P932PMC publication ID1444883
P698PubMed publication ID16632604
P5875ResearchGate publication ID7147411

P50authorAdriano BoassoQ55188047
Jakob NilssonQ55207977
P2093author name stringMatthew J Dolan
Jan Andersson
Michael J Kruhlak
Michel Dy
Jean-Philippe Herbeuval
Gene M Shearer
Andrew W Hardy
Stephanie A Anderson
P2860cites workHigh levels of HIV-1 in plasma during all stages of infection determined by competitive PCRQ22242246
CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractQ22242965
IRF-7 is the master regulator of type-I interferon-dependent immune responsesQ28511410
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosisQ29618601
The nature of the principal type 1 interferon-producing cells in human bloodQ29619763
Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins.Q33784777
Regulation of TNF-related apoptosis-inducing ligand on primary CD4+ T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cellsQ34014711
Probability binning comparison: a metric for quantitating univariate distribution differencesQ34095012
HIV-infected cells are major inducers of plasmacytoid dendritic cell interferon production, maturation, and migrationQ34466203
Role for plasmacytoid dendritic cells in anti-HIV innate immunityQ34560971
CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosisQ35847699
Plasmacytoid dendritic cells in immunityQ35953140
Interferon alpha and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS.Q36011366
Interleukin-1 beta converting enzyme-like protease involvement in Fas-induced and activation-induced peripheral blood T cell apoptosis in HIV infection. TNF-related apoptosis-inducing ligand can mediate activation-induced T cell death in HIV infectiQ36380721
Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapyQ36541079
Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cellsQ37730553
Viral infection switches non-plasmacytoid dendritic cells into high interferon producers.Q38973017
Natural alpha interferon-producing cells respond to human immunodeficiency virus type 1 with alpha interferon production and maturation into dendritic cellsQ39616950
In vivo analysis of Fas/FasL interactions in HIV-infected patients.Q39811836
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon inductionQ40437839
HIV type 1-infected dendritic cells induce apoptotic death in infected and uninfected primary CD4 T lymphocytesQ40578990
Active anti-interferon-alpha immunization: a European-Israeli, randomized, double-blind, placebo-controlled clinical trial in 242 HIV-1--infected patients (the EURIS study).Q40964230
Interferon-alpha and tumor necrosis factor-alpha in serum of patients in various stages of HIV-1 infectionQ41163422
Natural interferon alpha/beta-producing cells link innate and adaptive immunityQ41748252
Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNsQ42944061
Critical contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to apoptosis of human CD4+ T cells in HIV-1-infected hu-PBL-NOD-SCID miceQ42944373
Low levels of perforin expression in CD8+ T lymphocyte granules in lymphoid tissue during acute human immunodeficiency virus type 1 infectionQ43986794
Productive infection of T cells in lymphoid tissues during primary and early human immunodeficiency virus infectionQ45738778
Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells.Q51993308
The Fas/FasL system and T cell apoptosis in HIV-1-infected lymphoid tissue during highly active antiretroviral therapy.Q52016591
TRAIL/Apo-2-ligand-induced apoptosis in human T cells.Q54146049
Human alpha- and beta-interferon but not gamma- suppress the in vitro replication of LAV, HTLV-III, and ARV-2.Q55244180
Type I Interferon Production Is Profoundly and Transiently Impaired in Primary HIV‐1 InfectionQ62091076
Macrophages From Cancer Patients: Analysis of TRAIL, TRAIL Receptors, and Colon Tumor Cell ApoptosisQ73276141
Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patientsQ74330262
T cell proliferation and apoptosis in HIV-1-infected lymphoid tissue: impact of highly active antiretroviral therapyQ77084768
A dual role of IFN-alpha in the balance between proliferation and death of human CD4+ T lymphocytes during primary responseQ80542447
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectpatientQ181600
P304page(s)7000-7005
P577publication date2006-04-21
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleDifferential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients
P478volume103

Reverse relations

cites work (P2860)
Q36239431A randomized clinical trial of alternative stress management interventions in persons with HIV infection
Q27342233Attenuation of pathogenic immune responses during infection with human and simian immunodeficiency virus (HIV/SIV) by the tetracycline derivative minocycline
Q33366417Beneficial effect of TRAIL on HIV burden, without detectable immune consequences
Q27334176Blocking TLR7- and TLR9-mediated IFN-α production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection
Q35606616Blocking type I interferon production: a new therapeutic option to reduce the HIV-1-induced immune activation
Q34458060Blood myeloid dendritic cells from HIV-1-infected individuals display a proapoptotic profile characterized by decreased Bcl-2 levels and by caspase-3+ frequencies that are associated with levels of plasma viremia and T cell activation in an explorat
Q35991137CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells.
Q39419661CD4- and dynamin-dependent endocytosis of HIV-1 into plasmacytoid dendritic cells
Q38067705Characteristics of plasmacytoid dendritic cell and CD4+ T cell in HIV elite controllers
Q33613674Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation
Q28731004Chronic immune activation in HIV-1 infection contributes to reduced interferon alpha production via enhanced CD40:CD40 ligand interaction
Q36510689Chronic innate immune activation as a cause of HIV-1 immunopathogenesis
Q37073330Colony-Stimulating Factor 1 Receptor Antagonists Sensitize Human Immunodeficiency Virus Type 1-Infected Macrophages to TRAIL-Mediated Killing
Q33700312Contrasting roles for TLR ligands in HIV-1 pathogenesis
Q91910509Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment
Q34474320Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis
Q35752667DCs and NK cells: critical effectors in the immune response to HIV-1.
Q27010312Dendritic Cells in HIV-1 and HCV Infection: Can They Help Win the Battle?
Q38114911Dendritic cell dysregulation during HIV-1 infection
Q34657557Dendritic cells in progression and pathology of HIV infection.
Q34766895Dengue virus activates membrane TRAIL relocalization and IFN-α production by human plasmacytoid dendritic cells in vitro and in vivo.
Q37209049Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression
Q37033383Differential CD4+ T-lymphocyte apoptosis and bystander T-cell activation in rhesus macaques and sooty mangabeys during acute simian immunodeficiency virus infection
Q28082841Disease-promoting effects of type I interferons in viral, bacterial, and coinfections
Q38613681Effect of type-I interferon on retroviruses.
Q56994404Elite control of HIV infection: implications for vaccine design
Q37498946Following TRAIL's path in the immune system
Q26829456Foxo3a: an integrator of immune dysfunction during HIV infection
Q44134757HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaques.
Q92437362HIV elite control is associated with reduced TRAILshort expression
Q33413051HIV induces TRAIL sensitivity in hepatocytes
Q37000907HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells
Q35751070HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells
Q36141492HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-alpha
Q37676228HIV-1 immunopathogenesis in humanized mouse models
Q36656715HIV-1 immunopathogenesis: how good interferon turns bad.
Q36376089HIV-1 increases TLR responses in human primary astrocytes.
Q33359564HIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activation
Q50130203Haemophilia, human immunodeficiency virus and human immunodeficiency virus pathogenesis
Q27009024Host-pathogen interaction in HIV infection
Q35914497Human and simian immunodeficiency virus-mediated upregulation of the apoptotic factor TRAIL occurs in antigen-presenting cells from AIDS-susceptible but not from AIDS-resistant species
Q36540073Human immunodeficiency virus viremia induces plasmacytoid dendritic cell activation in vivo and diminished alpha interferon production in vitro.
Q38000415IFN-α and TRAIL: a double edge sword in HIV-1 disease?
Q41544565Ig-like transcript 7, but not bone marrow stromal cell antigen 2 (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid dendritic cell function in primary human blood leukocytes.
Q37254491Immune activation and the role of TLRs and TLR agonists in the pathogenesis of HIV-1 infection in the humanized mouse model
Q33992829Immune dysregulation in human immunodeficiency virus infection: know it, fix it, prevent it?
Q30362489Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?
Q35120242Immune suppression by neutrophils in HIV-1 infection: role of PD-L1/PD-1 pathway
Q36949540Immunology. An interferon paradox
Q33676532Inability of plasmacytoid dendritic cells to directly lyse HIV-infected autologous CD4+ T cells despite induction of tumor necrosis factor-related apoptosis-inducing ligand.
Q40129526Increased TNF-alpha and sTNFR2 levels are associated with high-grade anal squamous intraepithelial lesions in HIV-positive patients with low CD4 level
Q42225763Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates with chronic immune activation
Q28079717Innate and Adaptive Immune Regulation During Chronic Viral Infections
Q33997880Innate immune recognition and activation during HIV infection
Q40088680Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of Alpha Interferon.
Q34145979Interferon-alpha administration enhances CD8+ T cell activation in HIV infection
Q26861003Interferon-alpha, immune activation and immune dysfunction in treated HIV infection
Q55153874Interferon-α Subtypes As an Adjunct Therapeutic Approach for Human Immunodeficiency Virus Functional Cure.
Q34598849Interferon-α is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers
Q35370381Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis.
Q30912292Major depletion of plasmacytoid dendritic cells in HIV-2 infection, an attenuated form of HIV disease
Q42089377Marginal zone B-cells, a gatekeeper of innate immunity
Q34545417Mechanisms of HIV-associated lymphocyte apoptosis: 2010
Q48281703Mechanisms regulating expansion of CD8+ T cells during HIV-1 infection
Q36434255Next-Generation mRNA Sequencing Reveals Pyroptosis-Induced CD4+ T Cell Death in Early Simian Immunodeficiency Virus-Infected Lymphoid Tissues
Q37408390PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytes
Q33663298Pathogenic potential of interferon αβ in acute influenza infection
Q96304699Plasmacytoid Dendritic Cells as Cell-Based Therapeutics: A Novel Immunotherapy to Treat Human Immunodeficiency Virus Infection?
Q42121015Plasmacytoid and myeloid dendritic cells with a partial activation phenotype accumulate in lymphoid tissue during asymptomatic chronic HIV-1 infection
Q33608661Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients
Q37019332Plasmacytoid dendritic cells in HIV infection
Q33805319Plasmacytoid dendritic cells in HIV infection: striking a delicate balance
Q34261832Plasmacytoid dendritic cells mediate synergistic effects of HIV and lipopolysaccharide on CD27+ IgD- memory B cell apoptosis
Q35215887Plasmacytoid dendritic cells suppress HIV-1 replication but contribute to HIV-1 induced immunopathogenesis in humanized mice
Q38271917Potential implication of residual viremia in patients on effective antiretroviral therapy
Q33856394Potential role for HIV-specific CD38-/HLA-DR+ CD8+ T cells in viral suppression and cytotoxicity in HIV controllers
Q39630648Preferential cytolysis of peripheral memory CD4+ T cells by in vitro X4-tropic human immunodeficiency virus type 1 infection before the completion of reverse transcription
Q38035344Recent advances targeting innate immunity-mediated therapies against HIV-1 infection.
Q33649753Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1.
Q34627162Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α-producing and partially matured phenotype
Q47558114Sustained IFN-I Expression during Established Persistent Viral Infection: A "Bad Seed" for Protective Immunity.
Q35172090The Biology of TRAIL and the Role of TRAIL-Based Therapeutics in Infectious Diseases
Q26995244The Curious Case of Type I IFN and MxA: Tipping the Immune Balance in AIDS
Q35814700The Mechanism of Interferon Refractoriness During Hepatitis C Virus Infection and Its Reversal with a Peroxisome Proliferator-Activated Receptor α Agonist
Q27025707The enduring tale of T cells in HIV immunopathogenesis
Q36707747The innate antiviral response: new insights into a continuing story
Q33810779The macrophage in HIV-1 infection: from activation to deactivation?
Q37053199The role of cytokines in the pathogenesis and treatment of HIV infection
Q37942501The type I interferon response during viral infections: a "SWOT" analysis
Q37547157Therapeutic depletion of natural killer cells controls persistent infection.
Q27347804Tissue-specific B-cell dysfunction and generalized memory B-cell loss during acute SIV infection
Q40050805Transcriptomic meta-analysis identifies gene expression characteristics in various samples of HIV-infected patients with nonprogressive disease
Q37686199Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques
Q47548056Type I Interferon Responses by HIV-1 Infection: Association with Disease Progression and Control
Q38181142Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1.
Q52342680Type I interferon and HIV: Subtle balance between antiviral activity, immunopathogenesis and the microbiome.
Q35192786Type I interferon contributes to CD4+ T cell depletion induced by infection with HIV-1 in the human thymus
Q91841187Type I interferon in HIV treatment: from antiviral drug to therapeutic target
Q35018048Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection
Q36889683Type I interferon-dependent gene MxA in perinatal HIV-infected patients under antiretroviral therapy as marker for therapy failure and blood plasmacytoid dendritic cells depletion
Q37168039Type I interferons and interferon regulatory factors regulate TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected macrophages
Q28255842Type I interferons in infectious disease
Q36426325Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance
Q36625289Virus-encoded TLR ligands reveal divergent functional responses of mononuclear phagocytes in pathogenic simian immunodeficiency virus infection

Search more.