Postnatal erythropoietin treatment mitigates neural cell loss after systemic prenatal hypoxic-ischemic injury

scientific article published on September 1, 2010

Postnatal erythropoietin treatment mitigates neural cell loss after systemic prenatal hypoxic-ischemic injury is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3171/2010.5.PEDS1032
P953full work available at URLhttps://europepmc.org/articles/pmc3037962?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20809703/pdf/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20809703/?tool=EBI
https://europepmc.org/articles/PMC3037962
https://europepmc.org/articles/PMC3037962?pdf=render
https://doi.org/10.3171/2010.5.peds1032
https://thejns.org/view/journals/j-neurosurg-pediatr/6/3/article-p206.xml
https://thejns.org/downloadpdf/journals/j-neurosurg-pediatr/6/3/article-p206.xml
P932PMC publication ID3037962
P698PubMed publication ID20809703

P50authorMarcus D MazurQ127116014
P2093author name stringShenandoah Robinson
Robert H. Miller
P2860cites workErythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stressQ24611053
Recent trends in erythropoietin-mediated neuroprotectionQ24649547
A new mathematical model for relative quantification in real-time RT-PCRQ27860781
Regulated human erythropoietin receptor expression in mouse brainQ48558987
Arrested oligodendrocyte lineage progression during human cerebral white matter development: dissociation between the timing of progenitor differentiation and myelinogenesisQ48684211
Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain.Q48747468
Pretreatment with low doses of erythropoietin ameliorates brain damage in periventricular leukomalacia by targeting late oligodendrocyte progenitors: a rat modelQ48930723
The pharmacokinetics of erythropoietin in the cerebrospinal fluid after intravenous administration of recombinant human erythropoietinQ48962012
Distinctive neuropathologic alterations in the deep layers of the parietal cortex after moderate ischemic-hypoxic injury in the P3 immature rat brainQ48962363
Developmental changes induced by graded prenatal systemic hypoxic-ischemic insults in ratsQ48985335
Inhibitory effect on cerebral inflammatory agents that accompany traumatic brain injury in a rat model: a potential neuroprotective mechanism of recombinant human erythropoietin (rhEPO).Q50465111
Recombinant human erythropoietin administration protects cortical neurons from traumatic brain injury in rats.Q51722736
Long-term prognosis in children with neonatal seizures: a population-based study.Q51897641
Erythropoietin prevents long-term sensorimotor deficits and brain injury following neonatal hypoxia-ischemia in rats.Q51991847
Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide YQ59055743
Expression patterns of erythropoietin and its receptor in the developing spinal cord and dorsal root gangliaQ59264393
The economic consequences of preterm birth duringthe first 10 years of lifeQ61860210
Erythropoietin in the cerebrospinal fluid of neonates who sustained CNS injuryQ73131921
Erythropoietin-mediated preservation of the white matter in rat spinal cord injuryQ79400339
The effect of prenatal hypoxia on brain development: short- and long-term consequences demonstrated in rodent modelsQ28245123
Erythropoietin receptor signalling is required for normal brain developmentQ28507560
Encephalopathy of prematurity includes neuronal abnormalitiesQ30993427
Births: final data for 2005.Q31146787
Erythropoietin-induced neurovascular protection, angiogenesis, and cerebral blood flow restoration after focal ischemia in miceQ33262324
Impaired expression of neuroprotective molecules in the HIF-1alpha pathway following traumatic brain injury in aged miceQ33657749
Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury.Q34075461
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascadesQ34086191
A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery.Q34488111
Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal strokeQ34673506
Neonatal loss of gamma-aminobutyric acid pathway expression after human perinatal brain injuryQ35569033
Systemic prenatal insults disrupt telencephalon development: implications for potential interventionsQ35569038
Acute neuroprotective synergy of erythropoietin and insulin-like growth factor IQ36449204
TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injuryQ36545939
Erythropoietin crosses the blood-brain barrier to protect against experimental brain injuryQ37250532
Brain injury in premature infants: a complex amalgam of destructive and developmental disturbancesQ37253850
Brain protection by erythropoietin: a manifold task.Q37300838
Prolonged exposure to lead lowers the threshold of pentylenetetrazole-induced seizures in rats.Q39731463
Expression patterns of erythropoietin and its receptor in the developing midbrainQ42456856
A potential role for erythropoietin in focal permanent cerebral ischemia in mice.Q42473313
Apoptosis has a prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat.Q42495072
A phase I/II trial of high-dose erythropoietin in extremely low birth weight infants: pharmacokinetics and safetyQ42664024
An approach to using recombinant erythropoietin for neuroprotection in very preterm infantsQ43716045
Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordinationQ43981348
Placental HIFs as markers of cerebral hypoxic distress in fetal miceQ45229590
Erythropoietin improves functional and histological outcome in neonatal strokeQ46477576
Erythropoietin protects dopaminergic neurons and improves neurobehavioral outcomes in juvenile rats after neonatal hypoxia-ischemiaQ46628252
Erythropoietin prevents the increase in blood-brain barrier permeability during pentylentetrazol induced seizuresQ46847178
Erythropoietin improves long-term spatial memory deficits and brain injury following neonatal hypoxia-ischemia in ratsQ47285421
Chronic conditions, functional limitations, and special health care needs of school-aged children born with extremely low-birth-weight in the 1990sQ47374540
Improved survival rates with increased neurodevelopmental disability for extremely low birth weight infants in the 1990sQ47386422
Permanent focal cerebral ischemia activates erythropoietin receptor in the neonatal rat brainQ48090557
Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferationQ48119740
Erythropoietin exerts neuroprotective effect in neonatal rat model of hypoxic-ischemic brain injuryQ48197546
Pharmacokinetics of high-dose recombinant erythropoietin in plasma and brain of neonatal ratsQ48208417
Thalamocortical development of parvalbumin neurons in normal and periventricular leukomalacia brainsQ48223292
Coordinated developmental recruitment of latent fast spiking interneurons in layer IV barrel cortex.Q48247379
Safety of high-dose recombinant erythropoietin in a neonatal rat modelQ48250618
Neuroprotective effect of erythropoietin on hypoxic-ischemic brain injury in neonatal rats.Q48353017
Erythropoietin prevents ischemia-reperfusion from inducing oxidative damage in fetal rat brainQ48403878
The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.Q48421828
Erythropoietin is neuroprotective against NMDA-receptor-mediated excitotoxic brain injury in newborn mice.Q48426321
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
erythropoietinQ218706
P304page(s)206-221
P577publication date2010-09-01
P1433published inJournal of neurosurgery. PediatricsQ26841998
P1476titlePostnatal erythropoietin treatment mitigates neural cell loss after systemic prenatal hypoxic-ischemic injury
P478volume6

Reverse relations

cites work (P2860)
Q49826559A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis.
Q89173729A time for cocktails and inclusion
Q55437499Alterations of Both Dendrite Morphology and Weaker Electrical Responsiveness in the Cortex of Hip Area Occur Before Rearrangement of the Motor Map in Neonatal White Matter Injury Model.
Q36422327Cervical spinal erythropoietin induces phrenic motor facilitation via extracellular signal-regulated protein kinase and Akt signaling
Q34026944Complex pattern of interaction between in utero hypoxia-ischemia and intra-amniotic inflammation disrupts brain development and motor function.
Q90056963Current Evidence on Cell Death in Preterm Brain Injury in Human and Preclinical Models
Q35003575Developmental expression of N-methyl-D-aspartate (NMDA) receptor subunits in human white and gray matter: potential mechanism of increased vulnerability in the immature brain
Q36520524Erythropoietin Modulates Cerebral and Serum Degradation Products from Excess Calpain Activation following Prenatal Hypoxia-Ischemia
Q34053756Erythropoietin attenuates loss of potassium chloride co-transporters following prenatal brain injury
Q37496924Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor.
Q35909929Erythropoietin in brain development and beyond
Q37396967Erythropoietin signaling promotes oligodendrocyte development following prenatal systemic hypoxic-ischemic brain injury
Q57491952Extended Combined Neonatal Treatment With Erythropoietin Plus Melatonin Prevents Posthemorrhagic Hydrocephalus of Prematurity in Rats
Q55413545Extended Erythropoietin Treatment Prevents Chronic Executive Functional and Microstructural Deficits Following Early Severe Traumatic Brain Injury in Rats.
Q27005953Growth factors for the treatment of ischemic brain injury (growth factor treatment)
Q27345014Human Umbilical Cord Blood Cells Ameliorate Motor Deficits in Rabbits in a Cerebral Palsy Model
Q64263332Ibuprofen Treatment Reduces the Neuroinflammatory Response and Associated Neuronal and White Matter Impairment in the Growth Restricted Newborn
Q37724782Imaging and serum biomarkers reflecting the functional efficacy of extended erythropoietin treatment in rats following infantile traumatic brain injury.
Q55513191Mild Intrauterine Hypoperfusion Leads to Lumbar and Cortical Hyperexcitability, Spasticity, and Muscle Dysfunctions in Rats: Implications for Prematurity.
Q45162312Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Q89586204Neonatal and Long-Term Consequences of Fetal Growth Restriction
Q47216442Neonatal erythropoietin mitigates impaired gait, social interaction and diffusion tensor imaging abnormalities in a rat model of prenatal brain injury
Q39004400Neonatal hypoxic ischemic encephalopathy: an update on disease pathogenesis and treatment
Q37347049Neonatal posthemorrhagic hydrocephalus from prematurity: pathophysiology and current treatment concepts
Q60917211Neuropathology in intrauterine growth restricted newborn piglets is associated with glial activation and proinflammatory status in the brain
Q38188856Neuroprotective effects of erythropoiesis-stimulating agents in term and preterm neonates
Q35037632New antioxidant drugs for neonatal brain injury.
Q30405077Oligodendroglial alterations and the role of microglia in white matter injury: relevance to schizophrenia
Q37946499Organ-protective and immunomodulatory effects of erythropoietin--an update on recent clinical trials
Q26852406Pharmacologic neuroprotective strategies in neonatal brain injury
Q38760911Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives
Q35956626Postnatal Erythropoietin Mitigates Impaired Cerebral Cortical Development Following Subplate Loss from Prenatal Hypoxia-Ischemia
Q38365734Preclinical Models of Encephalopathy of Prematurity
Q36022351Prenatal Hypoxia-Ischemia Induces Abnormalities in CA3 Microstructure, Potassium Chloride Co-Transporter 2 Expression and Inhibitory Tone
Q39313813Prenatal Systemic Hypoxia-Ischemia and Oligodendroglia Loss in Cerebellum.
Q34249394Prenatal hypoxic-ischemic insult changes the distribution and number of NADPH-diaphorase cells in the cerebellum
Q40536441Relationship between serum erythropoietin levels and brain injury in preterm infants
Q53828021Repetitive Neonatal Erythropoietin and Melatonin Combinatorial Treatment Provides Sustained Repair of Functional Deficits in a Rat Model of Cerebral Palsy.
Q47112777Targeting inflammation to reduce brain injury in growth restricted newborns: A potential treatment?
Q61852472The fetus at the tipping point: modifying the outcome of fetal asphyxia
Q33631208The variability of autophagy and cell death susceptibility: Unanswered questions
Q57199037Therapeutic potential to reduce brain injury in growth restricted newborns
Q89879457Treatment of Neonatal Hypoxic-Ischemic Encephalopathy with Erythropoietin Alone, and Erythropoietin Combined with Hypothermia: History, Current Status, and Future Research

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