Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection

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Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...9k3691D
P356DOI10.1371/JOURNAL.PONE.0113691
P932PMC publication ID4244142
P698PubMed publication ID25423108
P5875ResearchGate publication ID268746862

P50authorRenato S AguiarQ57863458
P2093author name stringConstance Oliver
Eurico Arruda
Luis L P daSilva
Rodrigo O de Castro
Mara E da Silva-Januário
Maria C Jamur
Elaine Z M da Silva
Julianne V de Carvalho
Paola P Silveira
P2860cites workExosomal-like vesicles are present in human blood plasmaQ24303407
Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulationQ24532862
HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elementsQ24602320
Secretory mechanisms and intercellular transfer of microRNAs in living cellsQ24603413
ESCRT complexes and the biogenesis of multivesicular bodiesQ24646021
The use of lead citrate at high pH as an electron-opaque stain in electron microscopyQ26778439
HIV entry: a game of hide-and-fuse?Q26824979
T-cells play the classics with a different spinQ27023460
How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4Q27681494
Receptor downregulation and multivesicular-body sortingQ28131720
HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathwayQ28202962
Role of LBPA and Alix in multivesicular liposome formation and endosome organizationQ28240220
ExoCarta: A compendium of exosomal proteins and RNAQ28260686
Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipientsQ28284190
Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membraneQ28301729
Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infectionQ28304773
HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapyQ28339571
Dynamic interaction of HIV-1 Nef with the clathrin-mediated endocytic pathway at the plasma membrane.Q50706347
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.Q54148550
Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander CellsQ59667707
Ibalizumab: an anti-CD4 monoclonal antibody for the treatment of HIV-1 infection.Q64966141
HIV-Nef and AIDS pathogenesis: are we barking up the wrong tree?Q84602577
HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cellsQ37485148
Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytesQ37528880
Characterization of a continuous T-cell line susceptible to the cytopathic effects of the acquired immunodeficiency syndrome (AIDS)-associated retrovirusQ37546388
Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapseQ37629486
ALIX and the multivesicular endosome: ALIX in WonderlandQ38167245
The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef.Q40040583
Vpr.A3A chimera inhibits HIV replicationQ40040714
HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.Q40051245
Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4.Q40059306
Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1.Q40269589
Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivityQ40486921
Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transportQ40918547
A lipid associated with the antiphospholipid syndrome regulates endosome structure and functionQ41056430
The simian immunodeficiency virus Nef protein promotes degradation of CD4 in human T cells.Q41488065
Exosomes from breast milk inhibit HIV-1 infection of dendritic cells and subsequent viral transfer to CD4+ T cells.Q42233385
Induction of HTLV-III/LAV from a nonvirus-producing T-cell line: implications for latencyQ44325918
The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tailQ46855565
Maternal Pumilio acts together with Nanos in germline development in Drosophila embryosQ47070377
The low affinity IgG receptor Fc gamma RIIB contributes to the binding of the mast cell specific antibody, mAb BGD6Q28579563
Membrane vesicles as conveyors of immune responsesQ29547765
Isolation and characterization of exosomes from cell culture supernatants and biological fluidsQ29615035
Ceramide triggers budding of exosome vesicles into multivesicular endosomesQ29616811
Importance of the nef gene for maintenance of high virus loads and for development of AIDSQ29618369
Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assayQ29619255
Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization.Q30176459
Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable mannerQ33333829
HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cellsQ33363091
Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated stateQ33426352
High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolatesQ33760671
Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinaseQ33763110
Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor.Q34283497
RETRACTED: Pregnancy-associated exosomes and their modulation of T cell signalingQ34486229
HIV-1 coreceptors and their inhibitorsQ34506596
Exosome function: from tumor immunology to pathogen biologyQ34760438
Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signalingQ35005587
ADP ribosylation factor 1 activity is required to recruit AP-1 to the major histocompatibility complex class I (MHC-I) cytoplasmic tail and disrupt MHC-I trafficking in HIV-1-infected primary T cellsQ35531422
High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection.Q35872157
Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microgliaQ35879557
HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2.Q35949112
Nef proteins encoded by human and simian immunodeficiency viruses induce the accumulation of endosomes and lysosomes in human T cellsQ35965278
HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tailQ36322591
Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunityQ36343260
Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infectionQ36361799
The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophagesQ36362652
Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunitQ36424069
Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathwaysQ36499676
Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.Q36625495
Two mechanisms of soluble CD4 (sCD4)-mediated inhibition of human immunodeficiency virus type 1 (HIV-1) infectivity and their relation to primary HIV-1 isolates with reduced sensitivity to sCD4.Q36643604
Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivoQ36650992
HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice.Q36727308
HIV-1 Nef: at the crossroadsQ36926697
A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complexQ37110624
Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway.Q37232786
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)e113691
P577publication date2014-11-25
P1433published inPLOS OneQ564954
P1476titleNef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection
P478volume9

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cites work (P2860)
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Q30276544Exosomes in Viral Disease
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Q36796376Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line

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