Expression and activation of STAT3 in the astrocytes of optic nerve in a rat model of transient intraocular hypertension

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Expression and activation of STAT3 in the astrocytes of optic nerve in a rat model of transient intraocular hypertension is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...855683Z
P356DOI10.1371/JOURNAL.PONE.0055683
P932PMC publication ID3561308
P698PubMed publication ID23383263
P5875ResearchGate publication ID235403188

P2093author name stringChun Zhang
Ping Huang
Wenqian Wang
Weiyi Li
Shaodan Zhang
Samuel S Zhang
P2860cites workInduction of gp130-related Cytokines and Activation of JAK2/STAT3 Pathway in Astrocytes Precedes Up-regulation of Glial Fibrillary Acidic Protein in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of NeurodegenerationQ23916363
Increased plasma and optic nerve levels of IL-6, TNF-alpha, and MIP-2 following induction of ischemic optic neuropathy in mice.Q54538024
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Increased elastin expression in astrocytes of the lamina cribrosa in response to elevated intraocular pressureQ74439946
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Astrocytes in glaucomatous optic neuropathyQ42600591
Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J miceQ42914157
Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss.Q43187402
Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanismQ43519452
Rapid morphological changes in astrocytes are accompanied by redistribution but not by quantitative changes of cytoskeletal proteins.Q43747327
Upregulation of gp130 and STAT3 activation in the rat hippocampus following transient forebrain ischemiaQ44278548
A demonstration of glial filament distribution in astrocytes isolated from rat cerebral cortexQ44427271
Mitogen-activated protein kinases and retinal ischemiaQ44669147
STAT3 activation in response to growth factors or cytokines participates in retina precursor proliferationQ46566389
STAT3 activation protects retinal ganglion cell layer neurons in response to stressQ46601598
Glaucoma: macrocosm to microcosm the Friedenwald lectureQ46618750
Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucomaQ46704887
Inducible nitric oxide synthase inhibitors abolished histological protection by late ischemic preconditioning in rat retinaQ46730795
A central role of connexin 43 in hypoxic preconditioningQ46804903
Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model.Q46815689
Activation of JAK/STAT signalling in neurons following spinal cord injury in miceQ46897521
Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines.Q48177077
P2 purinergic receptors signal to STAT3 in astrocytes: Difference in STAT3 responses to P2Y and P2X receptor activationQ48448308
Impaired neuroglial activation in interleukin-6 deficient miceQ48789897
Induction of Stat3, a signal transducer and transcription factor, in reactive microglia following transient focal cerebral ischaemiaQ48843934
Glial cell response and iNOS expression in the optic nerve head and retina of the rat following acute high IOP ischemia-reperfusionQ49127766
Principles of interleukin (IL)-6-type cytokine signalling and its regulationQ24530173
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS modelQ24631645
Molecular dissection of reactive astrogliosis and glial scar formationQ24646628
Molecular evolution of type VI intermediate filament proteinsQ24679327
Signaling through the JAK/STAT pathway, recent advances and future challengesQ28201804
A road map for those who don't know JAK-STATQ28201970
Nestin structure and predicted function in cellular cytoskeletal organisationQ28237211
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neuronsQ28298056
CNTF promotes survival of retinal ganglion cells after induction of ocular hypertension in rats: the possible involvement of STAT3 pathwayQ28568156
Ciliary neurotrophic factor activates spinal cord astrocytes, stimulating their production and release of fibroblast growth factor-2, to increase motor neuron survivalQ28573797
Epidermal growth factor receptor activation: an upstream signal for transition of quiescent astrocytes into reactive astrocytes after neural injuryQ28581302
Expression and activation of STAT proteins during mouse retina developmentQ28593086
Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domainsQ29619208
Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamateQ29620128
Molecular mechanisms of astrogliosis: new approaches with mouse geneticsQ30443174
Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitroQ33540157
Structural remodeling of fibrous astrocytes after axonal injury.Q33723779
Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic miceQ33867506
Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander diseaseQ33929961
The morphology and spatial arrangement of astrocytes in the optic nerve head of the mouse.Q33975340
Expression profiles of nestin and synemin in reactive astrocytes and Müller cells following retinal injury: a comparison with glial fibrillar acidic protein and vimentinQ34381472
Astrocyte activation and reactive gliosisQ34413317
Reactive astrocytes in neural repair and protectionQ34449475
Cell Proliferation and Interleukin-6–Type Cytokine Signaling Are Implicated by Gene Expression Responses in Early Optic Nerve Head Injury in Rat GlaucomaQ34646791
Astrocyte influences on ischemic neuronal death.Q35699525
JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in ratsQ36063259
Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucomaQ36639100
Mechanisms of Disease: astrocytes in neurodegenerative diseaseQ36658874
STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injuryQ36974841
Inactivation of astroglial NF-kappa B promotes survival of retinal neurons following ischemic injury.Q37423557
Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptorsQ37448229
Signaling pathways in reactive astrocytes, a genetic perspectiveQ37828480
Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative StressQ38355236
Neuronal death in glaucomaQ40827206
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectastrocyteQ502961
P304page(s)e55683
P577publication date2013-01-31
P1433published inPLOS OneQ564954
P1476titleExpression and activation of STAT3 in the astrocytes of optic nerve in a rat model of transient intraocular hypertension
P478volume8

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cites work (P2860)
Q53558651Distribution of the cytoskeletal protein, Nestin, in acute leukemia.
Q26827435Glia-neuron interactions in the mammalian retina
Q38254447Insight into astrocyte activation after optic nerve injury
Q104795098MicroRNA-93/STAT3 signalling pathway mediates retinal microglial activation and protects retinal ganglion cells in an acute ocular hypertension model
Q36349121Optic nerve astrocyte reactivity protects function in experimental glaucoma and other nerve injuries.
Q92816595Papilledema from gain-of-function mutations in the STAT3 gene
Q47121687Pioglitazone ameliorates retinal ischemia/reperfusion injury via suppressing NLRP3 inflammasome activities
Q37669391Tetrandrine protects mouse retinal ganglion cells from ischemic injury.
Q51040094Therapeutic Retrobulbar Inhibition of STAT3 Protects Ischemic Retina Ganglion Cells.
Q89882550Topical recombinant human Nerve growth factor (rh-NGF) is neuroprotective to retinal ganglion cells by targeting secondary degeneration

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