n-3 polyunsaturated fatty acids and mechanisms to mitigate inflammatory paracrine signaling in obesity-associated breast cancer

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n-3 polyunsaturated fatty acids and mechanisms to mitigate inflammatory paracrine signaling in obesity-associated breast cancer is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/NU6114760
P932PMC publication ID4245562
P698PubMed publication ID25360510
P5875ResearchGate publication ID267746191

P50authorKrista A. PowerQ56102433
David W.L. MaQ61861719
P2093author name stringJennifer M Monk
Anna A De Boer
Danyelle M Liddle
Harmony F Turk
Lindsay E Robinson
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Docosahexaenoic acid attenuates macrophage-induced inflammation and improves insulin sensitivity in adipocytes-specific differential effects between LC n-3 PUFA.Q39433910
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Oleic acid promotes migration on MDA-MB-231 breast cancer cells through an arachidonic acid-dependent pathwayQ39772080
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Omega-3 polyunsaturated fatty acids down-modulate CXCR4 expression and function in MDA-MB-231 breast cancer cellsQ39830860
Effects of adiponectin and leptin co-treatment on human breast cancer cell growth.Q39855012
Berberine suppresses TNF-alpha-induced MMP-9 and cell invasion through inhibition of AP-1 activity in MDA-MB-231 human breast cancer cellsQ39909527
Adiponectin mediates an antiproliferative response in human MDA-MB 231 breast cancer cellsQ39936443
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(n-3) PUFA alter raft lipid composition and decrease epidermal growth factor receptor levels in lipid rafts of human breast cancer cellsQ40168854
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Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.Q40200727
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Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid.Q40266256
Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cellsQ40283150
Messenger RNA expression of leptin and leptin receptors and their prognostic value in 322 human primary breast cancersQ40293667
Exogenous supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA; 22:6n-3) synergistically enhances taxane cytotoxicity and downregulates Her-2/neu (c-erbB-2) oncogene expression in human breast cancer cellsQ40420649
Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPARgamma ligand rosiglitazoneQ40427831
Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1.Q40495451
Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells.Q40505823
Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptinQ40524984
Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells.Q40585585
Aromatase gene expression in adipose tissue: relationship to breast cancerQ40603109
Leptin Enhances, via AP-1, Expression of Aromatase in the MCF-7 Cell LineQ40649578
NF-kappa B inhibition by omega -3 fatty acids modulates LPS-stimulated macrophage TNF-alpha transcriptionQ40696197
Hypoxia-inducible factor 1 transactivates the human leptin gene promoterQ40705974
Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell lineQ40742670
Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: a quantitative electrospray ionization/mass spectrometric analysisQ40752849
Epidemiologic studies on Eskimos and fish intakeQ40835210
Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells.Q40910339
Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude miceQ40943565
Influence of diets containing eicosapentaenoic or docosahexaenoic acid on growth and metastasis of breast cancer cells in nude miceQ40988229
The 12-lipoxygenase gene-transfected MCF-7 human breast cancer cell line exhibits estrogen-independent, but estrogen and omega-6 fatty acid-stimulated proliferation in vitro, and enhanced growth in athymic nude miceQ41145966
Aromatase in the normal breast and breast cancerQ41640202
Effects of fatty acids and inhibitors of eicosanoid synthesis on the growth of a human breast cancer cell line in culture.Q41714713
Body mass index (BMI) and breast cancer: impact on tumor histopathologic features, cancer subtypes and recurrence rate in pre and postmenopausal womenQ42516483
Regulation of glucose transport and transporter 4 (GLUT-4) in muscle and adipocytes of sucrose-fed rats: effects of N-3 poly- and monounsaturated fatty acids.Q42525043
The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjectsQ42526334
Docosahexaenoic acid increases cellular adiponectin mRNA and secreted adiponectin protein, as well as PPARγ mRNA, in 3T3-L1 adipocytes.Q42777105
EGF induces coalescence of different lipid raftsQ42810682
Eicosapentaenoic acid prevents and reverses insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammationQ42820321
Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilizationQ42835415
Eicosapentaenoic acid and rosiglitazone increase adiponectin in an additive and PPARγ-dependent manner in human adipocytes.Q42918724
Effect of supplementation with different doses of DHA on the levels of circulating DHA as non-esterified fatty acid in subjects of Asian Indian background.Q51571220
N-3 polyunsaturated fatty acids endogenously synthesized in fat-1 mice are enriched in the mammary gland.Q51814042
Anthropometric measures, endogenous sex steroids and breast cancer risk in postmenopausal women: a study within the EPIC cohort.Q51956846
Reduction of enhanced mammary carcinogenesis in LA/N-cp (corpulent) rats by energy restriction.Q53499517
Modulation of visceral fat adipokine secretion by dietary fatty acids and ensuing changes in skeletal muscle inflammation.Q54378773
NFκB and MAPK signalling pathways mediate TNFα-induced Early Growth Response gene transcription leading to aromatase expression.Q54444540
Quantitative analysis of aromatase mRNA expression derived from various promoters (I.4, I.3, PII and I.7) and its association with expression of TNF-alpha, IL-6 and COX-2 mRNAs in human breast cancer.Q54631496
Endogenous receptor agonists: resolving inflammation.Q54943381
Inflammatory breast cancerQ57141656
Low-dose fish oil supplementation increases serum adiponectin without affecting inflammatory markers in overweight subjectsQ57734897
Omega-3 phospholipids from fish suppress hepatic steatosis by integrated inhibition of biosynthetic pathways in dietary obese miceQ59607817
The effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cellsQ59809289
Resolvin D1 and Its Precursor Docosahexaenoic Acid Promote Resolution of Adipose Tissue Inflammation by Eliciting Macrophage Polarization toward an M2-Like PhenotypeQ61575249
Increased upper body and overall adiposity is associated with decreased sex hormone binding globulin in postmenopausal womenQ67976337
Tumor necrosis factor-alpha stimulates aromatase gene expression in human adipose stromal cells through use of an activating protein-1 binding site upstream of promoter 1.4.Q71788029
Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) geneQ71826297
A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcriptionQ72265676
Regulation of aromatase expression in human tissuesQ72776902
Dietary n-3 fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, and white adipose tissue leptin and glucose transporter 4 in the ratQ73073494
Effects of reduced dietary linoleic acid intake, alone or combined with an algal source of docosahexaenoic acid, on MDA-MB-231 breast cancer cell growth and apoptosis in nude miceQ73332347
Low alpha-linolenic acid content of adipose breast tissue is associated with an increased risk of breast cancerQ73526627
Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancerQ74216208
Cytokines in human breast cancer: IL-1alpha and IL-1beta expressionQ77721557
Association of serum adiponectin levels with breast cancer riskQ79342715
Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n-3 polyunsaturated fatty acidsQ79749834
Adiponectin and leptin expression in primary ductal breast cancer and in adjacent healthy epithelial and myoepithelial tissueQ79786571
Leptin: a proliferative factor for breast cancer? Study on human ductal carcinomaQ80356847
Prostaglandin E(2) induces breast cancer related aromatase promoters via activation of p38 and c-Jun NH(2)-terminal kinase in adipose fibroblastsQ81310264
[Influence of hypoxia on leptin and leptin receptor gene expression of C57BL/6J mice]Q81689648
Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in miceQ82984507
ω-3 and ω-6 Polyunsaturated fatty acid intakes and the risk of breast cancer in Mexican women: impact of obesity statusQ83120592
Linking the inflammasome to obesity-related diseaseQ83379079
Delta-6-desaturase activity and arachidonic acid synthesis are increased in human breast cancer tissueQ86131456
Long-chain n-3 PUFAs reduce adipose tissue and systemic inflammation in severely obese nondiabetic patients: a randomized controlled trialQ87408172
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectomega-3 fatty acidQ191756
obesityQ12174
paracrine signalingQ14873666
breast neoplasmQ23929670
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)4760-4793
P577publication date2014-10-30
P1433published inNutrientsQ7070485
P1476titlen-3 polyunsaturated fatty acids and mechanisms to mitigate inflammatory paracrine signaling in obesity-associated breast cancer
P478volume6