c-Abl tyrosine kinase promotes adipocyte differentiation by targeting PPAR-gamma 2.

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c-Abl tyrosine kinase promotes adipocyte differentiation by targeting PPAR-gamma 2. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PNAS..11116365K
P356DOI10.1073/PNAS.1411086111
P932PMC publication ID4246298
P698PubMed publication ID25368164
P5875ResearchGate publication ID267814192

P2093author name stringYosef Shaul
Julia Adler
Matan Shanzer
Nina Reuven
Rom Keshet
Zina Bryansker Kraitshtein
P2860cites workRole for c-Abl tyrosine kinase in growth arrest response to DNA damage.Q41183906
Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion.Q41818769
The PPARgamma2 A/B-domain plays a gene-specific role in transactivation and cofactor recruitmentQ42289397
Dynamic protein pathway activation mapping of adipose-derived stem cell differentiation implicates novel regulators of adipocyte differentiationQ42595969
Down-regulation of platelet-derived growth factor receptor expression during terminal differentiation of 3T3-L1 pre-adipocyte fibroblastsQ42812177
Interdomain communication regulating ligand binding by PPAR-gammaQ42823872
Requirement of caspase-mediated cleavage of c-Abl during stress-induced apoptosisQ42833330
Plasma adiponectin levels are markedly elevated in imatinib-treated chronic myeloid leukemia (CML) patients: a mechanism for improved insulin sensitivity in type 2 diabetic CML patients?Q43064176
Genotoxic damage of human adipose-tissue derived mesenchymal stem cells triggers their terminal differentiation.Q43281360
Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactionsQ43626138
The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interfaceQ46178580
Long-term imatinib therapy promotes bone formation in CML patientsQ46278690
Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutationQ46671380
Suppression of PDGF-induced PI3 kinase activity by imatinib promotes adipogenesis and adiponectin secretionQ62087952
c-Abl stabilizes p73 by a phosphorylation-augmented interactionQ73537085
Abl expression in human fetal and adult tissues, tumours, and tumour microvesselsQ74016833
c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosinesQ74241732
Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivityQ24305397
Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damageQ24314457
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesisQ27860471
Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loopQ28138059
c-Abl: activation and nuclear targetsQ28138395
Interaction of c-Abl and p73alpha and their collaboration to induce apoptosisQ28138604
Identification of a ten-amino acid proline-rich SH3 binding siteQ28266446
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogeneQ28512170
An adipogenic cofactor bound by the differentiation domain of PPARgammaQ28586511
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factorQ29547912
Fat and beyond: the diverse biology of PPARgammaQ29615416
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancerQ29617271
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistanceQ29622888
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiationQ29871427
Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptorsQ33918083
Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts.Q34067118
The molecular control of adipogenesis, with special reference to lymphatic pathologyQ35051507
Isoform-specific functions of c-abl: type I is necessary for differentiation, and type IV is inhibitory to apoptosisQ36827735
Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenaseQ37153866
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivityQ38331543
Generation of megakaryocytes and platelets from preadipocyte cell line 3T3-L1, but not the parent cell line 3T3, in vitroQ39637396
PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesisQ39753643
Role of c-Abl in directing metabolic versus mitogenic effects in insulin receptor signaling.Q40109546
The nuclear receptor superfamily: a personal retrospect on the first two decadesQ40417646
Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modificationQ40559915
Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.Q40833566
Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgammaQ41144553
P433issue46
P407language of work or nameEnglishQ1860
P921main subjectadipocyteQ357519
P304page(s)16365-16370
P577publication date2014-11-03
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titlec-Abl tyrosine kinase promotes adipocyte differentiation by targeting PPAR-gamma 2.
P478volume111

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cites work (P2860)
Q64287734Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression
Q41965458Investigations on Binding Pattern of Kinase Inhibitors with PPARγ: Molecular Docking, Molecular Dynamic Simulations, and Free Energy Calculation Studies.
Q58692376KMUP-1, a GPCR Modulator, Attenuates Triglyceride Accumulation Involved MAPKs/Akt/PPARγ and PKA/PKG/HSL Signaling in 3T3-L1 Preadipocytes
Q49168585Over-expression of PPAR-γ2 gene enhances the adipogenic differentiation of hemangioma-derived mesenchymal stem cells in vitro and in vivo
Q91838742Peroxisome proliferator-activated receptor gamma as a theragnostic target for mesenchymal-type glioblastoma patients
Q54108748Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization.
Q57462658The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasome-mediated degradation of PPARγ
Q42236165c-Abl forces YAP to switch sides
Q42058768c-Abl inhibition mitigates diet-induced obesity through improving insulin sensitivity of subcutaneous fat in mice

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