Mechanism of therapeutic effect of high-dose intravenous immunoglobulin. Attenuation of acute, complement-dependent immune damage in a guinea pig model

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Mechanism of therapeutic effect of high-dose intravenous immunoglobulin. Attenuation of acute, complement-dependent immune damage in a guinea pig model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI114387
P932PMC publication ID304080
P698PubMed publication ID2687331

P2093author name stringBasta M
Frank MM
Fries LF
Kirshbom P
P2860cites workThe binding of complement component C3 to antibody-antigen aggregates after activation of the alternative pathway in human serumQ42154683
High-dose intravenous immunoglobulin modifies complement-mediated in vivo clearanceQ44905960
Complement-mediated tissue damage: contribution of the classical and alternate complement pathways in the Forssman reactionQ46899767
The Relative Efficacies of 7S and 19S Forssman Antibody in Producing Lesions in the Guinea PigQ54037256
The Treatment of Kawasaki Syndrome with Intravenous Gamma GlobulinQ58478448
Generation of low m.w., C3-bearing immunoglobulin in human serumQ70987006
Interaction of C3 and C3b with immunoglobulin GQ71048499
Immunopharmacological approach to Forssman shockQ71309662
Large scale isolation of functionally active components of the human complement systemQ71542480
A study of the cellular distribution of Forssman antigen in various speciesQ74255875
Intravenous immunoglobulins as therapeutic agentsQ33449825
Intravenous and standard immune serum globulin preparations interfere with uptake of 125I-C3 onto sensitized erythrocytes and inhibit hemolytic complement activityQ33459986
High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhoodQ33475647
Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferonQ34577395
Heterophile antibodies and tissue injury. 3. A role for platelets in the development of lethal vascular injury during Forssman shock in guinea pigsQ35864567
C3b covalently bound to IgG demonstrates a reduced rate of inactivation by factors H and IQ36349666
Classical complement pathway activation by antipneumococcal antibodies leads to covalent binding of C3b to antibody moleculesQ37102226
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectpigQ787
P304page(s)1974-1981
P577publication date1989-12-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleMechanism of therapeutic effect of high-dose intravenous immunoglobulin. Attenuation of acute, complement-dependent immune damage in a guinea pig model
P478volume84

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cites work (P2860)
Q3882035210% liquid human immunoglobulin (KIOVIG(®)) for immunomodulation in autoimmune disorders
Q34580488A Single Intravenous Infusion of Gamma Globulin as Compared with Four Infusions in the Treatment of Acute Kawasaki Syndrome
Q40790004Adverse effects of intravenous immunoglobulin
Q36602804Adverse effects of treatment with intravenous immunoglobulins for neurological diseases
Q36030537Age-related changes in the hepatic microcirculation in mice
Q71037753Animal models for complement deficiencies
Q72769499Anti-idiotypic activity against anti-myeloperoxidase antibodies in pooled human immunoglobulin
Q36359683Anti-inflammatory effect of intravenous immunoglobulin mediated through modulation of complement activation
Q34667057Antibodies in transplantation
Q71834117Beneficial effects of systemic immunoglobulin in experimental membranous nephropathy
Q33364381Can antibodies with specificity for soluble antigens mimic the therapeutic effects of intravenous IgG in the treatment of autoimmune disease?
Q35937151Dermatomyositis Developing in the first Trimester of Pregnancy
Q77819952Effect of intravenous immunoglobulin therapy on plasma complement
Q46793483Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis
Q71457783Efficacy of intravenous immunoglobulin therapy in a case of juvenile dermatomyositis
Q40667159F(ab)'2-mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins
Q88500050GM-CSF and IL-4 are not involved in IVIG-mediated amelioration of ITP in mice: a role for IL-11 cannot be ruled out
Q34155637High-dose intravenous immunoglobulin exerts its beneficial effect in patients with dermatomyositis by blocking endomysial deposition of activated complement fragments
Q87216501High-dose intravenous immunoglobulin exerts neuroprotective effect in the rat model of neonatal asphyxia
Q39579621Hyperferritinemia as indicator for intravenous immunoglobulin treatment in reactive macrophage activation syndromes
Q35161081IVIG--mechanisms of action.
Q37062115IVIg attenuates complement and improves spinal cord injury outcomes in mice.
Q72920759IgG inhibits the increase of platelet-associated C3 stimulated by anti-platelet antibodies
Q38346227IgM-enriched human introvenous immunoglobulin strongly inhibits complement-dependent porcine cell cytotoxicity mediated by human xenoreactive antibodies.
Q47712347Immune complex-like moieties in immunoglobulin for intravenous use (i.v.Ig) bind complement and enhance phagocytosis of human erythrocytes
Q34242612Immunoglobulin in the control of complement action
Q35766497Immunoglobulin prevents complement-mediated hyperacute rejection in swine-to-primate xenotransplantation
Q33596381Immunomodulating effects of intravenous immunoglobulin in autoimmune and inflammatory diseases
Q41663188In vitro effects of polyvalent immunoglobulin for intravenous use.
Q37877259Indications and safety of intravenous and subcutaneous immunoglobulin therapy
Q41822812Interaction of C3b(2)--IgG complexes with complement proteins properdin, factor B and factor H: implications for amplification
Q35795157Interaction of antibody with Forssman antigen in guinea pigs. A mechanism of adaptation to antibody- and complement-mediated injury
Q40673466Intravenous immune globulin in recurrent abortion.
Q73968578Intravenous immunoglobulin (IVIG) attenuates antibody binding in acute haemorrhagic immunopneumonitis in a rat model of complement-dependent lung injury
Q37487547Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways
Q48150515Intravenous immunoglobulin therapy in acute disseminated encephalomyelitis
Q33405903Intravenous immunoglobulin therapy: how does IgG modulate the immune system?
Q34124893Intravenous immunoglobulin treatment of experimental T cell-mediated autoimmune disease. Upregulation of T cell proliferation and downregulation of tumor necrosis factor alpha secretion
Q37433060Intravenous immunoglobulins (IVIg) in the treatment of autoimmune diseases
Q37626118Intravenous immunoglobulins--understanding properties and mechanisms
Q41589724Modulation of autoimmune responses by intravenous immunoglobulin (IVIg).
Q33339749New aspects in the pathogenesis and treatment of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
Q53965658Open trial of intravenous immune serum globulin for chronic sinusitis in children.
Q38372972Prophylactic treatment with sulphonated immunoglobulin G attenuates development of mechanical allodynia-like response in mice with neuropathic pain
Q34447342Recent advances in the immunology of xenotransplantation
Q57723250Selective induction of interleukin-1 receptor antagonist and interleukin-8 in human monocytes by normal polyspecific IgG (intravenous immunoglobulin)
Q58393545Self-reactive antibodies (natural autoantibodies) in healthy individuals
Q73501031The covalent interaction of C3 with IgG immune complexes
Q36731972The effects of intravenous immune globulin on complement-dependent immune damage of cells and tissues
Q41101079The growth arresting effect of human immunoglobulin for intravenous use is mediated by antibodies recognizing membrane glycolipids
Q41170285Therapeutic Potential of Intravenous Immunoglobulin in Acute Brain Injury
Q39729881Therapeutic effect of IVIG on inflammatory arthritis in mice is dependent on the Fc portion and independent of sialylation or basophils.
Q37622947Vascular involvement in the pathogenesis of idiopathic inflammatory myopathies
Q73085297[Immunomodulatory effects of intravenous immunoglobulins in autoimmune diseases]
Q80953233[Immunomodulatory effects of intravenous immunoglobulins]

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