A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes

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A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MBIO.00537-12
P932PMC publication ID3573662
P698PubMed publication ID23404398

P50authorKenneth W BaylesQ87960826
P2093author name stringRobert J Boissy
Jeffrey L Bose
Paul D Fey
Jennifer L Endres
Todd J Widhelm
Vijaya Kumar Yajjala
P2860cites workRegulation of hemolysin expression and virulence of Staphylococcus aureus by a serine/threonine kinase and phosphataseQ21136345
Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activityQ24646340
The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophageQ45267220
Regulation of exoprotein gene expression in Staphylococcus aureus by agar.Q54438418
Construction of single-copy integration vectors for Staphylococcus aureusQ68250938
Properties of a cryptic high-frequency transducing phage in Staphylococcus aureusQ68398098
Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophilsQ81180246
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulenceQ24650591
Staphyloxanthin plays a role in the fitness of Staphylococcus aureus and its ability to cope with oxidative stressQ24679533
Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesisQ27625375
Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureusQ28300379
Autoinduction and signal transduction in the regulation of staphylococcal virulenceQ29615337
Epidemic community-associated methicillin-resistant Staphylococcus aureus: recent clonal expansion and diversification.Q30367325
Mannitol-specific enzyme II of the phosphoenolpyruvate-dependent phosphotransferase system of Staphylococcus carnosus. Sequence and expression in Escherichia coli and structural comparison with the enzyme IImannitol of Escherichia coliQ31122865
Generating a collection of insertion mutations in the Staphylococcus aureus genome using bursa aurealisQ33327112
Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)Q33477111
SaeR binds a consensus sequence within virulence gene promoters to advance USA300 pathogenesisQ33557004
Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA.Q33954835
A genome-wide strategy for the identification of essential genes in Staphylococcus aureusQ34123679
Variation in extracellular protease production among clinical isolates of Staphylococcus aureus due to different levels of expression of the protease repressor sarA.Q34128652
Protease-armed bacteria in the skinQ34256463
Interactive microbial genome visualization with GViewQ34368339
Complete nucleotide sequence analysis of plasmids in strains of Staphylococcus aureus clone USA300 reveals a high level of identity among isolates with closely related core genome sequencesQ34433256
Microarray-based analysis of the Staphylococcus aureus sigmaB regulonQ34435080
Staphylococcus aureus CcpA affects virulence determinant production and antibiotic resistance.Q34510564
Genetic tools to enhance the study of gene function and regulation in Staphylococcus aureusQ34564815
Defining the strain-dependent impact of the Staphylococcal accessory regulator (sarA) on the alpha-toxin phenotype of Staphylococcus aureusQ35096183
Staphylococcal biofilm disassemblyQ35189445
Staphylococcus aureus CodY negatively regulates virulence gene expression.Q36540515
Recent horizontal transfer of a mariner transposable element among and between Diptera and NeuropteraQ36669659
Understanding how leading bacterial pathogens subvert innate immunity to reveal novel therapeutic targetsQ36867661
Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: establishing a national databaseQ37059039
Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissuesQ37355394
Staphylococcus aureus virulence genes identified by bursa aurealis mutagenesis and nematode killing.Q37485046
Papain-like proteases of Staphylococcus aureusQ37887583
SarT, a repressor of alpha-hemolysin in Staphylococcus aureusQ39521398
sigma(B) activity in Staphylococcus aureus is controlled by RsbU and an additional factor(s) during bacterial growthQ39523139
Plasmid incompatibility.Q39694297
Global regulatory impact of ClpP protease of Staphylococcus aureus on regulons involved in virulence, oxidative stress response, autolysis, and DNA repairQ40248431
A purified mariner transposase is sufficient to mediate transposition in vitroQ41077576
Differential target gene activation by the Staphylococcus aureus two-component system saeRS.Q41989725
Repression of hla by rot is dependent on sae in Staphylococcus aureusQ42215749
The two-component system ArlS-ArlR is a regulator of virulence gene expression in Staphylococcus aureusQ43674786
P433issue1
P921main subjectphenotypeQ104053
Staphylococcus aureusQ188121
P304page(s)e00537-12
P577publication date2013-02-12
P1433published inmBioQ15817061
P1476titleA genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes
P478volume4

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Q90253518Redirection of Metabolism in Response to Fatty Acid Kinase in Staphylococcus aureus
Q91658287Regulation of the Staphylococcal Superantigen-Like Protein 1 Gene of Community-Associated Methicillin-Resistant Staphylococcus aureus in Murine Abscesses
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Q33743269Resolving nonstop translation complexes is a matter of life or death
Q47105053Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of γ-actinorhodin
Q90572963RexAB is essential for the mutagenic repair of Staphylococcus aureus DNA damage caused by co-trimoxazole
Q36959053Ribosome hibernation factor promotes Staphylococcal survival and differentially represses translation
Q36081351Rifampin Resistance rpoB Alleles or Multicopy Thioredoxin/Thioredoxin Reductase Suppresses the Lethality of Disruption of the Global Stress Regulator spx in Staphylococcus aureus
Q35098233Role of BrnQ1 and BrnQ2 in branched-chain amino acid transport and virulence in Staphylococcus aureus
Q88989741Role of Purine Biosynthesis in Persistent Methicillin-Resistant Staphylococcus aureus Infection
Q47269544Roles of Staphylococcus aureus Mnh1 and Mnh2 Antiporters in Salt Tolerance, Alkali Tolerance, and Pathogenesis
Q52369586Roles of pyruvate dehydrogenase and branched-chain α-keto acid dehydrogenase in branched-chain membrane fatty acid levels and associated functions in Staphylococcus aureus.
Q35741753Rot is a key regulator of Staphylococcus aureus biofilm formation
Q40211756SaeRS Is Responsive to Cellular Respiratory Status and Regulates Fermentative Biofilm Formation in Staphylococcus aureus
Q53841129SbnI is a free serine kinase that generates O -phospho-l-serine for staphyloferrin B biosynthesis in Staphylococcus aureus.
Q62478185Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant
Q47407328Small RNA Teg49 is derived from a sarA transcript and regulates virulence genes independent of SarA in Staphylococcus aureus
Q40828402Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence.
Q91760134SosA inhibits cell division in Staphylococcus aureus in response to DNA damage
Q57075099Staphylococcal Enterotoxins Dose-Dependently Modulate the Generation of Myeloid-Derived Suppressor Cells
Q49609663Staphylococcus Aureus Triggers Induction of MIR-15B-5P to Diminish DNA Repair and De-Regulate inflammatory Response in Diabetic Foot Ulcers.
Q47586716Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide
Q35998835Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin
Q91235112Staphylococcus aureus ClpX localizes at the division septum and impacts transcription of genes involved in cell division, T7-secretion, and SaPI5-excision
Q37027315Staphylococcus aureus Coordinates Leukocidin Expression and Pathogenesis by Sensing Metabolic Fluxes via RpiRc.
Q28554121Staphylococcus aureus Exploits a Non-ribosomal Cyclic Dipeptide to Modulate Survival within Epithelial Cells and Phagocytes
Q50043456Staphylococcus aureus HemX Modulates Glutamyl-tRNA Reductase Abundance To Regulate Heme Biosynthesis.
Q48181578Staphylococcus aureus Responds to the Central Metabolite Pyruvate To Regulate Virulence
Q37182597Staphylococcus aureus Shifts toward Commensalism in Response to Corynebacterium Species
Q35821714Staphylococcus aureus Strain USA300 Perturbs Acquisition of Lysosomal Enzymes and Requires Phagosomal Acidification for Survival inside Macrophages
Q40495790Staphylococcus aureus SufT: an essential iron-sulphur cluster assembly factor in cells experiencing a high-demand for lipoic acid.
Q36152845Staphylococcus aureus Tissue Infection During Sepsis Is Supported by Differential Use of Bacterial or Host-Derived Lipoic Acid
Q38416186Staphylococcus aureus adapts to oxidative stress by producing H2O2-resistant small-colony variants via the SOS response.
Q92216522Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade
Q41757360Staphylococcus aureus alters growth activity, autolysis, and antibiotic tolerance in a human host-adapted Pseudomonas aeruginosa lineage
Q39112028Staphylococcus aureus biofilm: a complex developmental organism
Q50145889Staphylococcus aureus extracellular vesicles (EVs): surface-binding antagonists of biofilm formation
Q89636153Staphylococcus aureus fibronectin binding protein A mediates biofilm development and infection
Q27304596Staphylococcus aureus forms spreading dendrites that have characteristics of active motility
Q34298673Staphylococcus aureus hyaluronidase is a CodY-regulated virulence factor
Q55512748Staphylococcus aureus infection dynamics
Q46379131Staphylococcus aureus nitric oxide synthase (saNOS) modulates aerobic respiratory metabolism and cell physiology
Q89599909Staphylococcus aureus pigmentation is not controlled by Hfq
Q52629550Staphylococcus aureus utilizes host-derived lipoprotein particles as sources of exogenous fatty acids.
Q90148685Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells
Q93021098Strain-Specific Metabolic Requirements Revealed by a Defined Minimal Medium for Systems Analyses of Staphylococcus aureus
Q61795907Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence
Q55448117Structural modification of the tripeptide KPV by reductive "glycoalkylation" of the lysine residue.
Q92527744Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin
Q92089745Systematic evasion of the restriction-modification barrier in bacteria
Q36895642Systematic identification of conserved bacterial c-di-AMP receptor proteins
Q38674792Tandem Amplification of the Staphylococcal Cassette Chromosome mec Element Can Drive High-Level Methicillin Resistance in Methicillin-Resistant Staphylococcus aureus.
Q91753577Targeting Mannitol Metabolism as an Alternative Antimicrobial Strategy Based on the Structure-Function Study of Mannitol-1-Phosphate Dehydrogenase in Staphylococcus aureus
Q34384809Temporal and stochastic control of Staphylococcus aureus biofilm development
Q89068756Tet38 Efflux Pump Contributes to Fosfomycin Resistance in Staphylococcus aureus
Q92982494The (p)ppGpp-binding GTPase Era promotes rRNA processing and cold adaptation in Staphylococcus aureus
Q35812994The AirSR two-component system contributes to Staphylococcus aureus survival in human blood and transcriptionally regulates sspABC operon
Q48234684The ArlRS two-component system is a regulator of Staphylococcus aureus-induced endothelial cell damage.
Q92170151The ClpCP Complex Modulates Respiratory Metabolism in Staphylococcus aureus and Is Regulated in a SrrAB-Dependent Manner
Q41717997The ClpXP protease is dispensable for degradation of unfolded proteins in Staphylococcus aureus
Q28553511The DUF59 Containing Protein SufT Is Involved in the Maturation of Iron-Sulfur (FeS) Proteins during Conditions of High FeS Cofactor Demand in Staphylococcus aureus
Q37125647The Ktr potassium transport system in Staphylococcus aureus and its role in cell physiology, antimicrobial resistance and pathogenesis
Q35597691The MazEF Toxin-Antitoxin System Alters the β-Lactam Susceptibility of Staphylococcus aureus
Q64274625The Small RNA Teg41 Regulates Expression of the Alpha Phenol-Soluble Modulins and Is Required for Virulence in Staphylococcus aureus
Q35778485The Staphylococcus aureus ABC-Type Manganese Transporter MntABC Is Critical for Reinitiation of Bacterial Replication Following Exposure to Phagocytic Oxidative Burst
Q24316182The Staphylococcus aureus ArlRS two-component system is a novel regulator of agglutination and pathogenesis
Q28551807The Staphylococcus aureus Global Regulator MgrA Modulates Clumping and Virulence by Controlling Surface Protein Expression
Q41634510The Staphylococcus aureus NuoL-like protein MpsA contributes to the generation of membrane potential
Q36252696The Staphylococcus aureus SrrAB Regulatory System Modulates Hydrogen Peroxide Resistance Factors, Which Imparts Protection to Aconitase during Aerobic Growth
Q40062748The Staphylococcus aureus superantigen SElX is a bifunctional toxin that inhibits neutrophil function
Q38892531The Suf Iron-Sulfur Cluster Biosynthetic System Is Essential in Staphylococcus aureus, and Decreased Suf Function Results in Global Metabolic Defects and Reduced Survival in Human Neutrophils.
Q36208310The Two-Component System ArlRS and Alterations in Metabolism Enable Staphylococcus aureus to Resist Calprotectin-Induced Manganese Starvation.
Q41596253The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus
Q41710579The disruption of prenylation leads to pleiotropic rearrangements in cellular behavior in Staphylococcus aureus
Q40093376The identification of Staphylococcus aureus factors required for pathogenicity and growth in human blood
Q37017741The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction.
Q39864232The major autolysin is redundant for Staphylococcus aureus USA300 LAC JE2 virulence in a murine device-related infection model
Q36255010The membrane protein PrsS mimics σS in protecting Staphylococcus aureus against cell wall-targeting antibiotics and DNA-damaging agents
Q40127835The nucleoid occlusion factor Noc controls DNA replication initiation in Staphylococcus aureus
Q45821203The potential of trans-translation inhibitors as antibiotics
Q92883800The purine biosynthesis regulator PurR moonlights as a virulence regulator in Staphylococcus aureus
Q39428221The role of two branched-chain amino acid transporters in Staphylococcus aureus growth, membrane fatty acid composition and virulence
Q57294643Thermal and nutritional regulation of ribosome hibernation in
Q42162480Transcriptional downregulation of agr expression in Staphylococcus aureus during growth in human serum can be overcome by constitutively active mutant forms of the sensor kinase AgrC.
Q37105648Transcriptional profiling of Staphylococcus aureus during growth in 2 M NaCl leads to clarification of physiological roles for Kdp and Ktr K+ uptake systems
Q41674625Transposase-Mediated Excision, Conjugative Transfer, and Diversity of ICE6013 Elements in Staphylococcus aureus
Q36827106Various checkpoints prevent the synthesis of Staphylococcus aureus peptidoglycan hydrolase LytM in the stationary growth phase
Q42075252VfrB Is a Key Activator of the Staphylococcus aureus SaeRS Two-Component System
Q39516895VraH Is the Third Component of the Staphylococcus aureus VraDEH System Involved in Gallidermin and Daptomycin Resistance and Pathogenicity
Q36727985XerC Contributes to Diverse Forms of Staphylococcus aureus Infection via agr-Dependent and agr-Independent Pathways
Q47618178Yield Improvement of the Anti-MRSA Antibiotics WAP-8294A by CRISPR/dCas9 Combined with Refactoring Self-Protection Genes in Lysobacter enzymogenes OH11.
Q63761742coagulases are exploitable yet stable public goods in clinically relevant conditions
Q41953015β-Lactam resistance in methicillin-resistant Staphylococcus aureus USA300 is increased by inactivation of the ClpXP protease
Q35169008ω-Hydroxyemodin limits staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation.

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