Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexia syndrome: preclinical profile

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Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexia syndrome: preclinical profile is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1045660133
P356DOI10.1007/S13539-014-0159-5
P932PMC publication ID4248409
P698PubMed publication ID25267366
P5875ResearchGate publication ID266380387

P2093author name stringClaudio Pietra
Yasuhiro Takeda
Elizabeth Manning Duus
Masashi Minami
Naoko Tazawa-Ogata
Robert Northrup
Xia Yuanfeng
P2860cites workGhrelin is a growth-hormone-releasing acylated peptide from stomachQ22010951
High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507)Q28476277
Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trialQ30438239
Effects of ghrelin on anorexia in tumor-bearing mice with eicosanoid-related cachexiaQ33995715
Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia.Q34002856
Mechanisms of cancer cachexiaQ34016887
Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology GroupQ34057488
Definition and classification of cancer cachexia: an international consensusQ34162846
Cancer cachexia: traditional therapies and novel molecular mechanism-based approaches to treatmentQ34470745
Regulation of human growth hormone secretion and its disorders.Q34524927
Cancer cachexia: mechanisms and clinical implicationsQ34631019
Effects of an oral growth hormone secretagogue in older adultsQ34931335
Do patients with weight loss have a worse outcome when undergoing chemotherapy for lung cancers?Q36694116
Regulation of muscle mass by growth hormone and IGF-I.Q36736100
Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft modelQ37057597
Growth hormone releasing peptide 2 reverses anorexia associated with chemotherapy with 5-fluoruracil in colon cancer cell-bearing miceQ37396992
Effects of growth hormone on glucose, lipid, and protein metabolism in human subjectsQ37400457
Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategiesQ37781827
The potential of ghrelin in the treatment of cancer cachexia.Q38053171
The role of ghrelin in anorexia-cachexia syndromesQ38100324
Cancer cachexia pathophysiology and translational aspect of herbal medicineQ38112099
Growth hormone releasing hormone plasmid supplementation, a potential treatment for cancer cachexia, does not increase tumor growth in nude miceQ40514547
Immune enhancing effect of a growth hormone secretagogueQ40822121
Recombinant rat and mouse growth hormones: risk assessment of carcinogenic potential in 2-year bioassays in rats and miceQ42509878
Effects by daily long term provision of ghrelin to unselected weight-losing cancer patients: a randomized double-blind study.Q43148592
Effects of plasmid-mediated growth hormone-releasing hormone supplementation on LL-2 adenocarcinoma in miceQ44567179
Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteersQ46131774
Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies?Q47282777
Effect on body weight and safety of RC-1291, a novel, orally available ghrelin mimetic and growth hormone secretagogue: results of a phase I, randomized, placebo-controlled, multiple-dose study in healthy volunteersQ47286830
Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients: a prospective, randomized, placebo-controlled phase 2 studyQ48491599
Therapeutic potential of anamorelin, a novel, oral ghrelin mimetic, in patients with cancer-related cachexia: a multicenter, randomized, double-blind, crossover, pilot studyQ57480554
Pharmacokinetics and pharmacodynamic effects of an oral ghrelin agonist in healthy subjectsQ79734883
Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trialQ80167138
The role of C-terminal part of ghrelin in pharmacokinetic profile and biological activity in ratsQ83364785
P433issue4
P304page(s)329-337
P577publication date2014-09-30
P1433published inJournal of Cachexia, Sarcopenia and MuscleQ6294897
P1476titleAnamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexia syndrome: preclinical profile
P478volume5

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cites work (P2860)
Q37030111Anamorelin (ONO-7643) in Japanese patients with non-small cell lung cancer and cachexia: results of a randomized phase 2 trial
Q38772058Anamorelin for cancer anorexia-cachexia syndrome: a systematic review and meta-analysis
Q33419419Anamorelin for patients with cancer cachexia: an integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials
Q38462047Anamorelin hydrochloride for the treatment of cancer-anorexia-cachexia in NSCLC.
Q38636513Anamorelin hydrochloride in the treatment of cancer anorexia-cachexia syndrome: design, development, and potential place in therapy
Q50706662Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials.
Q42348565Anorexia of ageing: a key component in the pathogenesis of both sarcopenia and cachexia
Q91908525Appetite and food intake results from phase I studies of anamorelin
Q38555581Assessment of anticancer-treatment outcome in patients with metastatic castration-resistant prostate cancer-going beyond PSA and imaging, a systematic literature review.
Q38393457Cancer cachexia, recent advances, and future directions
Q36349371Deranged iron status in psoriasis: the impact of low body mass.
Q92881108Female Specific Association of Low Insulin-Like Growth Factor 1 (IGF1) Levels with Increased Risk of Premature Mortality in Renal Transplant Recipients
Q37690695From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation
Q26471773Ghrelin for the management of cachexia associated with cancer
Q57689439Ghrelin for the management of cachexia associated with cancer
Q37124526Increased Ghrelin but Low Ghrelin-Reactive Immunoglobulins in a Rat Model of Methotrexate Chemotherapy-Induced Anorexia
Q26775254Loss of muscle mass: current developments in cachexia and sarcopenia focused on biomarkers and treatment
Q90484081Management of Cancer Cachexia: Attempting to Develop New Pharmacological Agents for New Effective Therapeutic Options
Q34495485Moving on up: the Journal of Cachexia, Sarcopenia and Muscle
Q42398018Moving upwards - the journal of cachexia, sarcopenia and muscle in 2016.
Q43142441Novel mechanism of ghrelin therapy for cachexia
Q38887581Novel therapeutic options for cachexia and sarcopenia
Q41511150Oncology Update: Anamorelin
Q46213438Oodles of opportunities: the Journal of Cachexia, Sarcopenia and Muscle in 2017.
Q38672357Palliative Pharmacotherapy: State-of-the-Art Management of Symptoms in Patients With Cancer
Q55646811Quinolones Modulate Ghrelin Receptor Signaling: Potential for a Novel Small Molecule Scaffold in the Treatment of Cachexia.
Q47636085Recent advances in pharmacological, hormonal, and nutritional intervention for sarcopenia
Q39150802Relamorelin for the treatment of gastrointestinal motility disorders
Q46621430Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia
Q34669261Rikkunshito, a ghrelin potentiator, ameliorates anorexia-cachexia syndrome
Q33565870Synthetic Growth Hormone-Releasing Peptides (GHRPs): A Historical Appraisal of the Evidences Supporting Their Cytoprotective Effects
Q38670238The emerging role of anamorelin hydrochloride in the management of patients with cancer anorexia-cachexia
Q38564746The wasting continuum in heart failure: from sarcopenia to cachexia
Q33624632Therapeutic Potential of Targeting the Ghrelin Pathway

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