Histone deacetylases and phosphorylated polymerase II C-terminal domain recruit Spt6 for cotranscriptional histone reassembly

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Histone deacetylases and phosphorylated polymerase II C-terminal domain recruit Spt6 for cotranscriptional histone reassembly is …
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scholarly articleQ13442814

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P356DOI10.1128/MCB.00695-14
P932PMC publication ID4248711
P698PubMed publication ID25182531

P50authorCélia JeronimoQ64039212
P2093author name stringFrançois Robert
Rakesh Pathak
Chhabi K Govind
Jeffery W Jones
Bala Bharathi Burugula
P2860cites workThe Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and exportQ24293507
The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulationQ24294424
A Tandem SH2 Domain in Transcription Elongation Factor Spt6 Binds the Phosphorylated RNA Polymerase II C-terminal Repeat Domain (CTD)Q27664925
Noncanonical Tandem SH2 Enables Interaction of Elongation Factor Spt6 with RNA Polymerase IIQ27664927
Crystal Structures of the S. cerevisiae Spt6 Core and C-Terminal Tandem SH2 DomainQ27667298
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysisQ27860815
The role of chromatin during transcriptionQ27860995
NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5.Q27929814
Evidence that Spt6p controls chromatin structure by a direct interaction with histonesQ27931346
Uniform transitions of the general RNA polymerase II transcription complexQ27931804
Interaction between transcription elongation factors and mRNA 3'-end formation at the Saccharomyces cerevisiae GAL10-GAL7 locus.Q27931868
Transcription elongation factors repress transcription initiation from cryptic sites.Q27931897
Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5.Q27932002
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcriptionQ27932406
Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genesQ27932545
Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complexQ27932580
Exploration of essential gene functions via titratable promoter allelesQ27933619
Transcriptional activators are dispensable for transcription in the absence of Spt6-mediated chromatin reassembly of promoter regionsQ27934442
Phosphorylation of the Pol II CTD by KIN28 enhances BUR1/BUR2 recruitment and Ser2 CTD phosphorylation near promotersQ27935065
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complexQ27935315
Npl3 is an antagonist of mRNA 3' end formation by RNA polymerase II.Q27935622
Dimethylation of H3K4 by Set1 recruits the Set3 histone deacetylase complex to 5' transcribed regionsQ27936392
Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiaeQ27937704
Control of chromatin structure by spt6: different consequences in coding and regulatory regionsQ27937813
Yeast spt6-140 mutation, affecting chromatin and transcription, preferentially increases recombination in which Rad51p-mediated strand exchange is dispensableQ27938589
Roles for Ctk1 and Spt6 in regulating the different methylation states of histone H3 lysine 36.Q27939763
Genome-wide location and function of DNA binding proteinsQ28131765
Chromatin- and transcription-related factors repress transcription from within coding regions throughout the Saccharomyces cerevisiae genomeQ28756588
Bidirectional promoters generate pervasive transcription in yeastQ29614766
Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3' end processingQ29614768
Progression through the RNA polymerase II CTD cycleQ29614782
VAP: a versatile aggregate profiler for efficient genome-wide data representation and discoveryQ30806058
TFIIH phosphorylation of the Pol II CTD stimulates mediator dissociation from the preinitiation complex and promoter escape.Q33671365
DSIF and RNA Polymerase II CTD Phosphorylation Coordinate the Recruitment of Rpd3S to Actively Transcribed GenesQ33742112
SPT4, SPT5 and SPT6 interactions: effects on transcription and viability in Saccharomyces cerevisiaeQ33959909
Mutations in the SPT4, SPT5, and SPT6 genes alter transcription of a subset of histone genes in Saccharomyces cerevisiaeQ33968082
Phosphorylated Pol II CTD Recruits Multiple HDACs, Including Rpd3C(S), for Methylation-Dependent Deacetylation of ORF NucleosomesQ34118607
High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongationQ35205005
Solution structure of tandem SH2 domains from Spt6 protein and their binding to the phosphorylated RNA polymerase II C-terminal domainQ35310103
The cellular protein SPT6 is required for efficient replication of human cytomegalovirusQ35826617
The spt5 C-terminal region recruits yeast 3' RNA cleavage factor I.Q35826689
Set3 HDAC mediates effects of overlapping noncoding transcription on gene induction kinetics.Q36287609
Spt6 prevents transcription-coupled loss of posttranslationally modified histone H3.Q37011438
Cracking the RNA polymerase II CTD codeQ37155088
Spt6 enhances the elongation rate of RNA polymerase II in vivoQ37196147
Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex.Q37302219
Set2-dependent K36 methylation is regulated by novel intratail interactions within H3Q37452562
Spt6 regulates intragenic and antisense transcription, nucleosome positioning, and histone modifications genome-wide in fission yeastQ37469459
Kin28 regulates the transient association of Mediator with core promotersQ38929299
Measuring dynamic changes in histone modifications and nucleosome density during activated transcription in budding yeastQ39374491
Infrequently transcribed long genes depend on the Set2/Rpd3S pathway for accurate transcriptionQ41889467
A feed forward circuit comprising Spt6, Ctk1 and PAF regulates Pol II CTD phosphorylation and transcription elongationQ41892815
Gene-specific RNA polymerase II phosphorylation and the CTD codeQ42075763
A role for phosphorylated Pol II CTD in modulating transcription coupled histone dynamicsQ42702235
Gene promoters dictate histone occupancy within genesQ42955960
Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions.Q53577981
CTD tyrosine phosphorylation impairs termination factor recruitment to RNA polymerase II.Q54500955
A universal RNA polymerase II CTD cycle is orchestrated by complex interplays between kinase, phosphatase, and isomerase enzymes along genesQ83344227
P4510describes a project that useslimmaQ112236343
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)4115-4129
P577publication date2014-09-02
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleHistone deacetylases and phosphorylated polymerase II C-terminal domain recruit Spt6 for cotranscriptional histone reassembly
P478volume34