Quinacrine inhibits Candida albicans growth and filamentation at neutral pH.

scientific article

Quinacrine inhibits Candida albicans growth and filamentation at neutral pH. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.03083-14
P932PMC publication ID4249548
P698PubMed publication ID25288082

P2093author name stringHallie S Rane
Karlett J Parra
Samuel A Lee
Stella M Bernardo
Alba Chavez-Dozal
Maximillian Jahng
Vibhati V Kulkarny
P2860cites workCandida albicans VPS1 contributes to protease secretion, filamentation, and biofilm formationQ42278085
Susceptibility of Candida albicans biofilms to azithromycin, tigecycline and vancomycin and the interaction between tigecycline and antifungalsQ42946675
The relation of the plasma concentration of quinacrine to its antimalarial activity.Q47932816
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Role of pH response in Candida albicans virulenceQ74322287
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Antifungal lock therapyQ27025682
Identification of Saccharomyces cerevisiae genes conferring resistance to quinoline ring-containing antimalarial drugsQ27937633
A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeastQ28131611
Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus neoformans by a mechanism independent of iron deprivationQ28379104
Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancersQ28743513
Candida biofilms: an updateQ30475833
Candida albicans VMA3 is necessary for V-ATPase assembly and function and contributes to secretion and filamentationQ30555316
The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolatesQ34112865
Factors affecting filamentation in Candida albicans: changes in respiratory activity of Candida albicans during filamentationQ34123462
Antifungal activity of amphotericin B, fluconazole, and voriconazole in an in vitro model of Candida catheter-related bloodstream infectionQ34142971
The fungal pathogen Candida albicans autoinduces hyphal morphogenesis by raising extracellular pH.Q35006284
Candida biofilms and their role in infectionQ35044563
Amphotericin B: current understanding of mechanisms of actionQ35247730
Role of the V-ATPase in regulation of the vacuolar fission-fusion equilibriumQ36016989
Multiple methods of visualizing the yeast vacuole permit evaluation of its morphology and inheritance during the cell cycleQ36216944
The where, when, and how of organelle acidification by the yeast vacuolar H+-ATPaseQ36416690
Deletion of vacuolar proton-translocating ATPase V(o)a isoforms clarifies the role of vacuolar pH as a determinant of virulence-associated traits in Candida albicansQ36647246
Antifungal combinations against Candida albicans biofilms in vitroQ36879905
Essential role for vacuolar acidification in Candida albicans virulenceQ37151114
The yeast lysosome-like vacuole: endpoint and crossroadsQ37266848
Our current understanding of fungal biofilmsQ37622959
New insights into mechanisms of therapeutic effects of antimalarial agents in SLE.Q38026787
The use of quinacrine (Atabrine) in rheumatic diseases: a reexaminationQ38637388
Candida albicans biofilms produce antifungal-tolerant persister cellsQ39077924
In vitro activity of antifungal combinations against Candida albicans biofilmsQ39526786
4-Aminoquinolines--past, present, and future: a chemical perspectiveQ40866974
Metabolism of alpha-factor by a mating type cells of Saccharomyces cerevisiaeQ40993410
Differential activities of newer antifungal agents against Candida albicans and Candida parapsilosis biofilmsQ41912237
Conditional lethality of the diprotic weak bases chloroquine and quinacrine against Cryptococcus neoformansQ41921505
High affinity capture and concentration of quinacrine in polymorphonuclear neutrophils via vacuolar ATPase-mediated ion trapping: comparison with other peripheral blood leukocytes and implications for the distribution of cationic drugsQ42265851
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectCandida albicansQ310443
P1104number of pages9
P304page(s)7501-7509
P577publication date2014-10-06
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleQuinacrine inhibits Candida albicans growth and filamentation at neutral pH.
P478volume58

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cites work (P2860)
Q90693077'Acridines' as New Horizons in Antifungal Treatment
Q38526460Combinatorial drug approaches to tackle Candida albicans biofilms
Q61808000Drug Repurposing for the Treatment of Bacterial and Fungal Infections
Q41037695Effect of 2, 4-di-tert-butylphenol on growth and biofilm formation by an opportunistic fungus Candida albicans
Q92525201High Efficiency Drug Repurposing Design for New Antifungal Agents
Q38684254Proton Transport and pH Control in Fungi

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