You're one in a googol: optimizing genes for protein expression.

scientific article

You're one in a googol: optimizing genes for protein expression. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1098/RSIF.2008.0520.FOCUS
P932PMC publication ID2843954
P698PubMed publication ID19324676
P5875ResearchGate publication ID24237435

P50authorClaes GustafssonQ55300680
P2093author name stringJeremy Minshull
Alan Villalobos
Mark Welch
P2860cites workGene Designer: a synthetic biology tool for constructing artificial DNA segmentsQ21284253
SimulFold: simultaneously inferring RNA structures including pseudoknots, alignments, and trees using a Bayesian MCMC frameworkQ21563523
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Comparison of correspondence analysis methods for synonymous codon usage in bacteriaQ24657604
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A simple model based on mutation and selection explains trends in codon and amino-acid usage and GC composition within and across genomesQ24797873
Co-transcriptional folding is encoded within RNA genesQ24803935
GeMS: an advanced software package for designing synthetic genesQ24806471
What makes ribosome-mediated transcriptional attenuation sensitive to amino acid limitation?Q24811430
JCat: a novel tool to adapt codon usage of a target gene to its potential expression hostQ24812232
Do universal codon-usage patterns minimize the effects of mutation and translation error?Q24813693
tRNA properties help shape codon pair preferences in open reading framesQ25256741
Evolutionary programming as a platform for in silico metabolic engineeringQ25257616
Optimization by Simulated AnnealingQ25939004
Environmental genome shotgun sequencing of the Sargasso SeaQ27860605
Heterologous protein expression is enhanced by harmonizing the codon usage frequencies of the target gene with those of the expression host.Q30369393
Directed evolution of a genetic circuitQ30870894
Unexpected correlations between gene expression and codon usage bias from microarray data for the whole Escherichia coli K-12 genomeQ30884442
Codon bias at the 3'-side of the initiation codon is correlated with translation initiation efficiency in Escherichia coliQ32062779
Near-critical behavior of aminoacyl-tRNA pools in E. coli at rate-limiting supply of amino acidsQ33208194
Expanding the metabolic engineering toolbox: more options to engineer cellsQ33270419
Sequence similarity is more relevant than species specificity in probabilistic backtranslation.Q33274888
OptCircuit: an optimization based method for computational design of genetic circuitsQ33322237
Highly conserved regimes of neighbor-base-dependent mutation generated the background primary-structural heterogeneities along vertebrate chromosomesQ33334428
Natural computation meta-heuristics for the in silico optimization of microbial strainsQ33387681
Recombinant protein expression in Escherichia coliQ33744852
Secondary structure of the ribosome binding site determines translational efficiency: a quantitative analysisQ33825350
Nonrandom utilization of codon pairs in Escherichia coliQ33857615
Codon bias and heterologous protein expressionQ33979754
Metabolic efficiency and amino acid composition in the proteomes of Escherichia coli and Bacillus subtilisQ34019786
Translation is a non-uniform process. Effect of tRNA availability on the rate of elongation of nascent polypeptide chainsQ34054633
Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: A proposal for a synonymous codon choice that is optimal for the E. coli translational systemQ34054909
Codon usage in bacteria: correlation with gene expressivityQ34056325
Effects of rare codon clusters on high-level expression of heterologous proteins in Escherichia coliQ34058060
Synonymous codon bias is related to gene length in Escherichia coli: selection for translational accuracy?Q34063045
Ribosome-mediated translational pause and protein domain organizationQ34063382
Selective charging of tRNA isoacceptors induced by amino-acid starvationQ34166656
Gene expression and molecular evolutionQ34420781
Strategies for optimizing heterologous protein expression in Escherichia coliQ34458728
Reconstruction of genetic circuitsQ34470075
Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation.Q34594316
Revisiting the codon adaptation index from a whole-genome perspective: analyzing the relationship between gene expression and codon occurrence in yeast using a variety of modelsQ34966113
Influences of mRNA secondary structure on initiation by eukaryotic ribosomesQ35602187
Correlation between mechanical strength of messenger RNA pseudoknots and ribosomal frameshiftingQ35719907
Mechanisms of elongation on the ribosome: dynamics of a macromolecular machineQ35922844
Recognition and selection of tRNA in translationQ36024296
Synthetic biology--putting engineering into biologyQ36586096
Control of translation by mRNA secondary structure in Escherichia coli. A quantitative analysis of literature dataQ36727373
Designing biological systemsQ36731984
Following translation by single ribosomes one codon at a time.Q36915705
Engineering and applications of genetic circuitsQ37000368
Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minimaQ37066299
Engineering prokaryotic gene circuitsQ37328414
mRNA helicase activity of the ribosomeQ38331986
Ribosomal pausing at a frameshifter RNA pseudoknot is sensitive to reading phase but shows little correlation with frameshift efficiencyQ39529314
Gratuitous overexpression of genes in Escherichia coli leads to growth inhibition and ribosome destructionQ39836003
Effects of a minor isoleucyl tRNA on heterologous protein translation in Escherichia coliQ39839470
A codon window in mRNA downstream of the initiation codon where NGG codons give strongly reduced gene expression in Escherichia coliQ40157109
Codon usage bias from tRNA's point of view: redundancy, specialization, and efficient decoding for translation optimizationQ40299578
Reduced synonymous substitution rate at the start of enterobacterial genesQ40415708
Codon catalog usage is a genome strategy modulated for gene expressivityQ40495447
Suppression of the negative effect of minor arginine codons on gene expression; preferential usage of minor codons within the first 25 codons of the Escherichia coli genesQ40515131
Codon usage and gene expressionQ40561153
Errors of heterologous protein expressionQ41238667
Synonymous substitution rates in enterobacteria.Q41659361
Optimal encoding rules for synthetic genes: the need for a community effortQ42560165
The effects of differential gene expression on coding sequence features: analysis by one-way ANOVA.Q42621346
Frameshift events associated with the lysyl-tRNA and the rare arginine codon, AGA, in Escherichia coli: a case study involving the human Relaxin 2 proteinQ42655130
Coevolution of codon usage and transfer RNA abundanceQ43851327
Influences on translation initiation and early elongation by the messenger RNA region flanking the initiation codon at the 3' sideQ44009176
Effects of codon usage versus putative 5'-mRNA structure on the expression of Fusarium solani cutinase in the Escherichia coli cytoplasmQ44268096
Kinetic determinants of high-fidelity tRNA discrimination on the ribosomeQ44753572
Codon pair utilization biases influence translational elongation step timesQ46515085
Unfolding of mRNA secondary structure by the bacterial translation initiation complexQ46838029
Genetdes: automatic design of transcriptional networksQ48402161
Codon pairs in the genome of Escherichia coli.Q50796273
Limitations of codon adaptation index and other coding DNA-based features for prediction of protein expression in Saccharomyces cerevisiae.Q51986650
Codon contexts from weakly expressed genes reduce expression in vivo.Q52244607
Eukaryotic expression: developments for structural proteomics.Q52672667
Rates of aminoacyl-tRNA selection at 29 sense codons in vivo.Q52867127
Codon contexts in enterobacterial and coliphage genes.Q52869362
Co-variation of tRNA abundance and codon usage in Escherichia coli at different growth rates.Q52888301
Selective charging of tRNA isoacceptors explains patterns of codon usage.Q54523461
Effect of distribution of unfavourable codons on the maximum rate of gene expression by an heterologous organism.Q54780371
Sense codons are found in specific contexts.Q54798749
Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study.Q55048769
Role of the AGA/AGG codons, the rarest codons in global gene expression in Escherichia coliQ72801102
Construct for high-level expression and low misincorporation of lysine for arginine during expression of pET-encoded eukaryotic proteins in Escherichia coliQ73206776
Cooperative effects by the initiation codon and its flanking regions on translation initiationQ74608439
Mutation-selection models of codon substitution and their use to estimate selective strengths on codon usageQ80454136
Abortive translation caused by peptidyl-tRNA drop-off at NGG codons in the early coding region of mRNAQ81339352
P304page(s)S467-76
P577publication date2009-03-11
P1433published inJournal of the Royal Society InterfaceQ2492390
P1476titleYou're one in a googol: optimizing genes for protein expression
P478volume6 Suppl 4

Reverse relations

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