Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a randomised controlled trial

scientific article

Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a randomised controlled trial is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1742-1241.2009.02143.X
P932PMC publication ID2779994
P698PubMed publication ID19614786
P5875ResearchGate publication ID26678691

P2093author name stringR Chen
S Ravichandran
G H Tan
A Apanovitch
A R Chacra
CV181-040 Investigators
J List
P2860cites workOral Antidiabetic AgentsQ22241436
Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of DiabetesQ24642503
Translating the A1C assay into estimated average glucose valuesQ24655833
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) GroupQ27860882
Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetesQ28262769
DPP-4 inhibitors and their potential role in the management of type 2 diabetesQ28271159
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetesQ29619192
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapyQ29620534
Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group.Q33864120
Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysisQ34648377
Sulfonylurea treatment of type 2 diabetes mellitus: focus on glimepirideQ35783714
Earlier intervention in type 2 diabetes: the case for achieving early and sustained glycaemic control.Q36291021
Mechanisms of beta-cell death in type 2 diabetes.Q36321520
Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes.Q36519973
An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatment.Q36949127
Glucose metabolism and hyperglycemiaQ37050752
The burden of treatment failure in type 2 diabetesQ40500624
A model-based method for assessing insulin sensitivity from the oral glucose tolerance testQ43566553
Combination therapy with rosiglitazone and glibenclamide compared with upward titration of glibenclamide alone in patients with type 2 diabetes mellitusQ44752163
Comparison of uptitration of gliclazide with the addition of rosiglitazone to gliclazide in patients with type 2 diabetes inadequately controlled on half-maximal doses of a sulphonylureaQ44956964
Sulfonylurea induced beta-cell apoptosis in cultured human isletsQ45105959
Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: a randomized controlled trial.Q45974567
The risk of heart failure in patients with type 2 diabetes treated with oral agent monotherapyQ46525578
Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetesQ46691051
Standards of medical care in diabetes--2008.Q46828447
Effects of rosiglitazone added to submaximal doses of metformin compared with dose escalation of metformin in type 2 diabetes: the EMPIRE StudyQ46861155
Causes of weight gain during insulin therapy with and without metformin in patients with Type II diabetes mellitusQ47265873
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.Q51561183
Association between oral antidiabetic use, adverse events and outcomes in patients with type 2 diabetes.Q51745195
American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitusQ80572896
P433issue9
P921main subjectpatientQ181600
type 2 diabetesQ3025883
P304page(s)1395-1406
P577publication date2009-07-15
P1433published inInternational Journal of Clinical PracticeQ15758177
P1476titleSaxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a randomised controlled trial
P478volume63

Reverse relations

cites work (P2860)
Q83176026A dipeptidyl peptidase-4 inhibitor for adults with type 2 diabetes
Q46100468A randomized controlled trial of the efficacy and safety of saxagliptin as add-on therapy in patients with type 2 diabetes and inadequate glycaemic control on metformin plus a sulphonylurea
Q35102138A randomized controlled trial of the efficacy and safety of twice-daily saxagliptin plus metformin combination therapy in patients with type 2 diabetes and inadequate glycemic control on metformin monotherapy
Q28282265A systematic assessment of cardiovascular outcomes in the saxagliptin drug development program for type 2 diabetes
Q28275281Addition of dipeptidyl peptidase-4 inhibitors to sulphonylureas and risk of hypoglycaemia: systematic review and meta-analysis
Q33732627Assessment of Saxagliptin Efficacy: Meta-Analysis of 14 Phase 2 and 3 Clinical Trials
Q26829445Assessment of pancreatic β-cell function: review of methods and clinical applications
Q37568863Assessment of the cardiovascular safety of saxagliptin in patients with type 2 diabetes mellitus: pooled analysis of 20 clinical trials
Q37517909Beyond metformin: safety considerations in the decision-making process for selecting a second medication for type 2 diabetes management: reflections from a diabetes care editors' expert forum
Q59487668Bioequivalence of Saxagliptin/Metformin Extended-Release (XR) Fixed-Dose Combination Tablets and Single-Component Saxagliptin and Metformin XR Tablets in Healthy Adult Chinese Subjects
Q35717211Clinical trial simulation methods for estimating the impact of DPP-4 inhibitors on cardiovascular disease
Q38468017Clinical use of dipeptidyl peptidase-4 and sodium-glucose cotransporter 2 inhibitors in combination therapy for type 2 diabetes mellitus
Q35236019Clinical utility of dipeptidyl peptidase-4 inhibitors: a descriptive summary of current efficacy trials
Q37346737Clinically relevant reductions in HbA1c without hypoglycaemia: results across four studies of saxagliptin
Q33785197Comparative effectiveness of dipeptidylpeptidase-4 inhibitors in type 2 diabetes: a systematic review and mixed treatment comparison
Q58701706Comparison of antidiabetic drugs added to sulfonylurea monotherapy in patients with type 2 diabetes mellitus: A network meta-analysis
Q38116766Complementing insulin therapy to achieve glycemic control
Q38154679Composite endpoints in trials of type-2 diabetes
Q35570938Cost effectiveness of dipeptidyl peptidase-4 inhibitors for type 2 diabetes
Q91638366DPP-4 Inhibition and the Path to Clinical Proof
Q40487459DPP-4 inhibitors and risk of infections: a meta-analysis of randomized controlled trials.
Q37638984DPP-4 inhibitors in clinical practice.
Q37612696Defining the importance of daily glycemic control and implications for type 2 diabetes management
Q35497064Determinants of saxagliptin use among patients with type 2 diabetes mellitus treated with oral anti-diabetic drugs
Q37995760Differentiating among incretin therapies: a multiple-target approach to type 2 diabetes
Q41863397Differentiating among incretin-based therapies in the management of patients with type 2 diabetes mellitus
Q34214474Dipeptidyl Peptidase-4 (DPP-4) Inhibitors In the Management of Diabetes
Q38603506Dipeptidyl Peptidase-4 Inhibitors in Diverse Patient Populations With Type 2 Diabetes
Q58829034Dipeptidyl peptidase-4 inhibitors and HbA1c target of <7% in type 2 diabetes: meta-analysis of randomized controlled trials
Q35026483Dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes: safety, tolerability, and efficacy
Q37778379Dipeptidylpeptidase-4 inhibitors (gliptins): focus on drug-drug interactions
Q36315963Effects of dipeptidyl peptidase-4 inhibitors on beta-cell function and insulin resistance in type 2 diabetes: meta-analysis of randomized controlled trials
Q45985301Effects of saxagliptin on β-cell stimulation and insulin secretion in patients with type 2 diabetes.
Q53354332Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes: meta-analysis.
Q39855313Efficacy and safety of linagliptin in type 2 diabetes subjects at high risk for renal and cardiovascular disease: a pooled analysis of six phase III clinical trials
Q34454269Efficacy and safety of saxagliptin as add-on therapy in type 2 diabetes
Q45545993Efficacy and safety of saxagliptin combination therapy in US patients with type 2 diabetes
Q42914097Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adult patients with type 2 diabetes mellitus
Q51365356Efficacy and safety of saxagliptin in drug-naïve Asian patients with type 2 diabetes mellitus: a randomized controlled trial.
Q55262447Efficacy and safety of saxagliptin in patients with type 2 diabetes: A systematic review and meta-analysis.
Q51292505Efficacy and safety of saxagliptin monotherapy or added to metformin in Chinese patients with type 2 diabetes mellitus: results from the 24-week, post-marketing SUNSHINE study.
Q33731748Efficacy and safety of vildagliptin, Saxagliptin or Sitagliptin as add-on therapy in Chinese patients with type 2 diabetes inadequately controlled with dual combination of traditional oral hypoglycemic agents
Q43462577Efficacy of dipeptidyl-peptidase-4 inhibitors and impact on β-cell function in Asian and Caucasian type 2 diabetes mellitus patients: A meta-analysis
Q34381281Emerging treatment options for type 2 diabetes
Q38645792Emerging use of combination therapies for the management of type 2 diabetes - focus on saxagliptin and dapagliflozin
Q36954446Encounter frequency and serum glucose level, blood pressure, and cholesterol level control in patients with diabetes mellitus
Q41958385Evaluation of pharmacokinetic drug interactions between gemigliptin (dipeptidylpeptidase-4 inhibitor) and glimepiride (sulfonylurea) in healthy volunteers
Q38219482Evidence-based practice use of incretin-based therapy in the natural history of diabetes
Q38795046Factors Related to the Glucose-Lowering Efficacy of Dipeptidyl Peptidase-4 Inhibitors: A Systematic Review and Meta-Analysis Focusing on Ethnicity and Study Regions
Q37835612Focus on incretin-based therapies: targeting the core defects of type 2 diabetes
Q37900151From theory to clinical practice in the use of GLP-1 receptor agonists and DPP-4 inhibitors therapy
Q43116132GLP-1: a new therapeutic principle for the treatment of type 2 diabetes mellitus
Q33535235Impact of data from recent clinical trials on strategies for treating patients with type 2 diabetes mellitus
Q38264374Implications of incretin-based therapies on cardiovascular disease.
Q38479567Improved glucose control with reduced hypoglycaemic risk when linagliptin is added to basal insulin in elderly patients with type 2 diabetes
Q37653125Incorporating incretin-based therapies into clinical practice for patients with type 2 diabetes
Q37781456Incretin-based Therapy in Chronic Kidney Disease
Q38140803Incretin-based therapies: focus on effects beyond glycemic control alone
Q37780914Incretin-based therapies: review of the outpatient literature with implications for use in the hospital and after discharge
Q38036773Individualized treatment of type 2 diabetes mellitus using noninsulin agents: clinical considerations for the primary care physician
Q83470443Influence of renal or hepatic impairment on the pharmacokinetics of saxagliptin
Q57688763Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease
Q39157526Intensifying Treatment Beyond Monotherapy in Type 2 Diabetes Mellitus: Where Do Newer Therapies Fit?
Q50876843Long-term 4-year safety of saxagliptin in drug-naive and metformin-treated patients with Type 2 diabetes.
Q34154661Long-term safety and tolerability of saxagliptin add-on therapy in older patients (aged ≥ 65 years) with type 2 diabetes
Q51367101Long-term treatment with the dipeptidyl peptidase-4 inhibitor saxagliptin in patients with type 2 diabetes mellitus and renal impairment: a randomised controlled 52-week efficacy and safety study.
Q38214060Management of unmet needs in type 2 diabetes mellitus: the role of incretin agents
Q37828337Multifactorial intervention in Type 2 diabetes: the promise of incretin-based therapies
Q42058426New treatments in the management of type 2 diabetes: a critical appraisal of saxagliptin
Q38089327Novel therapies for the management of type 2 diabetes mellitus: Part 2. Addressing the incretin defect in the clinical setting in 2013.
Q34783302Overview of saxagliptin efficacy and safety in patients with type 2 diabetes and cardiovascular disease or risk factors for cardiovascular disease
Q37446672Pathogenesis and management of postprandial hyperglycemia: role of incretin-based therapies
Q38470357Pharmacokinetic study of saxagliptin in healthy Chinese subjects
Q38350347Pharmacologic treatment of type 2 diabetes: oral medications
Q37910902Pharmacology of dipeptidyl peptidase-4 inhibitors: similarities and differences.
Q46071500Predictors of response to dipeptidyl peptidase-4 inhibitors: evidence from randomized clinical trials
Q51280718Randomized trial assessing the safety and efficacy of sitagliptin in Chinese patients with type 2 diabetes mellitus inadequately controlled on sulfonylurea alone or combined with metformin.
Q37682555Reaching HbA1c goals with saxagliptin in combination with other oral antidiabetic drugs
Q38026956Recent advances in incretin-based therapies
Q33886865Role of saxagliptin as monotherapy or adjunct therapy in the treatment of type 2 diabetes
Q33412360Safety of saxagliptin: events of special interest in 9156 patients with type 2 diabetes mellitus
Q28259979Saxagliptin
Q37239303Saxagliptin Efficacy and Safety in Patients With Type 2 Diabetes and Moderate Renal Impairment
Q34078449Saxagliptin and sitagliptin in adult patients with type 2 diabetes: a systematic review and meta-analysis
Q51339320Saxagliptin efficacy and safety in patients with type 2 diabetes mellitus and cardiovascular disease history or cardiovascular risk factors: results of a pooled analysis of phase 3 clinical trials.
Q38420531Saxagliptin efficacy and safety in patients with type 2 diabetes mellitus stratified by cardiovascular disease history and cardiovascular risk factors: analysis of 3 clinical trials
Q38753500Saxagliptin for the treatment of diabetes - a focus on safety
Q34128612Saxagliptin for the treatment of type 2 diabetes mellitus: assessing cardiovascular data
Q37963451Saxagliptin for the treatment of type 2 diabetes mellitus: focus on recent studies
Q34620486Saxagliptin for type 2 diabetes
Q40524112Saxagliptin improves glycaemic control and C-peptide secretion in latent autoimmune diabetes in adults (LADA).
Q28278863Saxagliptin overview: special focus on safety and adverse effects
Q44896736Saxagliptin vs. glipizide as add-on therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: long-term (52-week) extension of a 52-week randomised controlled trial
Q38592351Saxagliptin: A Review in Type 2 Diabetes
Q36139126Saxagliptin: A Selective DPP-4 Inhibitor for the Treatment of Type 2 Diabetes Mellitus
Q37784644Saxagliptin: A dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes mellitus
Q35411329Saxagliptin: A dipeptidyl peptidase-4 inhibitor in the treatment of type 2 diabetes mellitus
Q37973413Saxagliptin: a review of its use as combination therapy in the management of type 2 diabetes mellitus in the EU.
Q34239784Saxagliptin: the evidence for its place in the treatment of type 2 diabetes mellitus
Q42371758The Use of Saxagliptin in People with Type 2 Diabetes in France: The Diapazon Epidemiological Study
Q37977335The alpha-cell as target for type 2 diabetes therapy.
Q38134902The cardiovascular safety of incretin-based therapies: a review of the evidence
Q37992253The design of the liraglutide clinical trial programme
Q33866808The evolving place of incretin-based therapies in type 2 diabetes
Q38137027The incidence of mild and severe hypoglycaemia in patients with type 2 diabetes mellitus treated with sulfonylureas: a systematic review and meta-analysis
Q37641333The intersection of safety and adherence: new incretin-based therapies in patients with type 2 diabetes mellitus
Q38205588The pharmacokinetic considerations and adverse effects of DPP-4 inhibitors [corrected].
Q51365002The pharmacologic basis for clinical differences among GLP-1 receptor agonists and DPP-4 inhibitors.
Q38088195The place of GLP-1-based therapy in diabetes management: differences between DPP-4 inhibitors and GLP-1 receptor agonists
Q35760288The role of incretin therapy at different stages of diabetes
Q38024383The role of self-monitoring of blood glucose in glucagon-like peptide-1-based treatment approaches: a European expert recommendation
Q36785098Tolerability and efficacy of glycemic control with saxagliptin in older patients (aged ≥ 65 years) with inadequately controlled type 2 diabetes mellitus
Q42171281Type 2 diabetes comorbidities and treatment challenges: rationale for DPP-4 inhibitors
Q42818432Update on the latest family of oral drugs marketed for the treatment of type 2 diabetes: DPP-4 inhibitors. Contributions with respect to other families of oral antidiabetic agents
Q37857686Use of DPP-4 inhibitors in type 2 diabetes: focus on sitagliptin
Q36327126Utility of Saxagliptin in the Treatment of Type 2 Diabetes: Review of Efficacy and Safety

Search more.