A genetic screen for suppressors and enhancers of the Drosophila cdk1-cyclin B identifies maternal factors that regulate microtubule and microfilament stability

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A genetic screen for suppressors and enhancers of the Drosophila cdk1-cyclin B identifies maternal factors that regulate microtubule and microfilament stability is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID1462342
P698PubMed publication ID12454065

P2093author name stringLawrence S B Goldstein
Marjan Haghnia
Jun-Yuan Ji
Cory Trusty
Gerold Schubiger
P2860cites workBni1p, a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesisQ24310527
A yeast actin-related protein homologous to that in vertebrate dynactin complex is important for spindle orientation and nuclear migration.Q27932051
Myosin V orientates the mitotic spindle in yeastQ27936159
Interaction of the p62 subunit of dynactin with Arp1 and the cortical actin cytoskeletonQ28140958
DNA-replication checkpoint control at the Drosophila midblastula transitionQ28243128
Determination of cell division axes in the early embryogenesis of Caenorhabditis elegansQ28302830
Diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene.Q42687958
chickadee encodes a profilin required for intercellular cytoplasm transport during Drosophila oogenesisQ43854212
Mutations affecting the cytoskeletal organization of syncytial Drosophila embryosQ44100799
Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesisQ44706870
Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggsQ44974709
The regulatory light chain of nonmuscle myosin is encoded by spaghetti-squash, a gene required for cytokinesis in DrosophilaQ45232088
Behavior of structurally divergent alpha-tubulin isotypes during Drosophila embryogenesis: evidence for post-translational regulation of isotype abundanceQ46256152
Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganizationQ47071618
FH proteins as cytoskeletal organizersQ47721514
A maternal form of the phosphatase Cdc25A regulates early embryonic cell cycles in Xenopus laevisQ47941104
Actin-related protein 1 and cytoplasmic dynein-based motility - what's the connection?Q47986544
Profilin is required for posterior patterning of the Drosophila oocyte.Q48062808
Intercellular cytoplasm transport during Drosophila oogenesisQ49086087
Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development.Q52169038
The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition.Q52177829
Drosophila nonmuscle myosin II has multiple essential roles in imaginal disc and egg chamber morphogenesis.Q52201910
A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogaster.Q52223574
Permeabilization of Drosophila eggs.Q52470996
Profilin mutations disrupt multiple actin-dependent processes during Drosophila development.Q52537233
Cyclin A and B functions in the early Drosophila embryo.Q52574233
Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesisQ70445366
In vivo regulation of the early embryonic cell cycle in XenopusQ71012175
Localization of antigenic determinants in whole Drosophila embryosQ72711990
Profilin promotes barbed-end actin filament assembly without lowering the critical concentrationQ73279843
Colocalization of cytoplasmic dynein with dynactin and CLIP-170 at microtubule distal endsQ77353305
Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethalityQ28592982
The dynactin complex is required for cleavage plane specification in early Caenorhabditis elegans embryosQ28611336
Principles of CDK regulationQ29547820
Universal control mechanism regulating onset of M-phaseQ29616481
Whose end is destruction: cell division and the anaphase-promoting complexQ29618257
Microtubules and mitotic cycle phase modulate spatiotemporal distributions of F-actin and myosin II in Drosophila syncytial blastoderm embryos.Q30854908
Flying through the drosophila cytoskeletal genome.Q30887463
Dosage-dependent modifiers of polycomb and antennapedia mutations in DrosophilaQ33663555
Functional cooperation between the microtubule and actin cytoskeletonsQ33840293
The role of local actin instability in axon formationQ33855372
The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cellsQ33890771
The genetics of the dorsal-Bicaudal-D region of Drosophila melanogasterQ33952161
The metaphase II arrest in mouse oocytes is controlled through microtubule-dependent destruction of cyclin B in the presence of CSF.Q34060695
How profilin promotes actin filament assembly in the presence of thymosin beta 4.Q34345724
Identification of chromosomal regions involved in decapentaplegic function in DrosophilaQ34604225
Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesisQ34609955
Identification of autosomal regions involved in Drosophila Raf functionQ34610569
A genetic screen for suppressors and enhancers of the Drosophila PAN GU cell cycle kinase identifies cyclin B as a targetQ34613014
Cyclin synthesis drives the early embryonic cell cycleQ34667885
Dynamic actin structures stabilized by profilin.Q35055080
Cooperative interactions between the central spindle and the contractile ring during Drosophila cytokinesis.Q35189660
Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylationQ35200340
Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B.Q35211606
Dynamic changes in microtubule configuration correlate with nuclear migration in the preblastoderm Drosophila embryoQ36232595
How an actin network might cause fountain streaming and nuclear migration in the syncytial Drosophila embryoQ36234939
Lava lamp, a novel peripheral golgi protein, is required for Drosophila melanogaster cellularizationQ36316531
The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryoQ36530877
Control of microtubule dynamics and length by cyclin A- and cyclin B-dependent kinases in Xenopus egg extracts.Q36531791
Role of astral microtubules and actin in spindle orientation and migration in the budding yeast, Saccharomyces cerevisiaeQ36532119
Interacting proteins identified by genetic interactions: a missense mutation in alpha-tubulin fails to complement alleles of the testis-specific beta-tubulin gene of Drosophila melanogasterQ36767202
Genes encoding actin-related proteins of Drosophila melanogasterQ38305270
Direct observation of microtubule-f-actin interaction in cell free lysatesQ38324375
Mutant Caldesmon lacking cdc2 phosphorylation sites delays M-phase entry and inhibits cytokinesis.Q38671060
Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth coneQ39291439
Functional analysis of the Drosophila diaphanous FH protein in early embryonic developmentQ41728562
Cyclins A and B associate with chromatin and the polar regions of spindles, respectively, and do not undergo complete degradation at anaphase in syncytial Drosophila embryos.Q41875175
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
actin filamentQ329638
P1104number of pages17
P304page(s)1179-1195
P577publication date2002-11-01
P1433published inGeneticsQ3100575
P1476titleA genetic screen for suppressors and enhancers of the Drosophila cdk1-cyclin B identifies maternal factors that regulate microtubule and microfilament stability
P478volume162

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cites work (P2860)
Q39069482Argonaute-1 functions as a mitotic regulator by controlling Cyclin B during Drosophila early embryogenesis.
Q37300885Both cyclin B levels and DNA-replication checkpoint control the early embryonic mitoses in Drosophila
Q34294435Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression
Q35623708Drosophila Wee1 interacts with members of the gammaTURC and is required for proper mitotic-spindle morphogenesis and positioning
Q34569397Drosophila melanogaster Prat, a purine de novo synthesis gene, has a pleiotropic maternal-effect phenotype
Q33729427Formins in development: orchestrating body plan origami
Q35641483Onset of the DNA replication checkpoint in the early Drosophila embryo
Q34424308Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics.
Q34619335l(3)malignant brain tumor and three novel genes are required for Drosophila germ-cell formation.

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