Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia

scientific article

Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.2399
P932PMC publication ID4253427
P698PubMed publication ID25229333
P5875ResearchGate publication ID265735322

P2093author name stringYehuda G Assaraf
Michal Stark
Shachar Raz
P2860cites workAnalysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cellsQ21260431
Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencingQ24294291
Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell linesQ24534739
Transcription factor binding sites in the pol gene intragenic regulatory region of HIV-1 are important for virus infectivityQ24815940
Folate-binding triggers the activation of folylpolyglutamate synthetaseQ27634058
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein geneQ28507391
Cooperation between complexes that regulate chromatin structure and transcriptionQ29614769
Conserved role of intragenic DNA methylation in regulating alternative promotersQ29616289
Folylpoly-gamma-glutamate synthetase gene mRNA splice variants and protein expression in primary human leukemia cells, cell lines, and normal human tissues.Q33942935
Regulation of human CYP2C9 expression by electrophilic stress involves activator protein 1 activation and DNA looping.Q34024630
Signaling of transforming growth factor-beta family members through Smad proteinsQ34098846
Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repressionQ34316282
Transcription of the human folylpoly-gamma-glutamate synthetase geneQ34440673
Mechanisms of TGF-beta signaling in regulation of cell growth and differentiationQ34635877
Molecular basis for decreased folylpoly-gamma-glutamate synthetase expression in a methotrexate resistant CCRF-CEM mutant cell lineQ34652639
Differential Inhibition of the TGF-β Signaling Pathway in HCC Cells Using the Small Molecule Inhibitor LY2157299 and the D10 Monoclonal Antibody against TGF-β Receptor Type II.Q34796473
Transforming growth factor-beta signaling in normal and malignant hematopoiesisQ35217394
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencingQ36256943
TGF-β inhibition enhances chemotherapy action against triple-negative breast cancerQ36638173
The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis.Q36648346
Molecular basis of antifolate resistanceQ36749419
Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor beta transcriptional programQ37216412
Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexateQ37351011
Nucleosomal fluctuations govern the transcription dynamics of RNA polymerase II.Q37417788
Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.Q37527174
TGF-β: duality of function between tumor prevention and carcinogenesis.Q37634488
Genome-wide mechanisms of Smad binding.Q38011947
Antifolates in cancer therapy: structure, activity and mechanisms of drug resistanceQ38037835
Intragenic DNA methylation in transcriptional regulation, normal differentiation and cancerQ38128454
Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.Q38359462
Targeted expression of human folylpolyglutamate synthase for selective enhancement of methotrexate chemotherapy in osteosarcoma cellsQ39109782
Down-regulation and CpG island hypermethylation of CRYAA in age-related nuclear cataractQ39298160
BRG1 helps RNA polymerase II to overcome a nucleosomal barrier during elongation, in vivoQ39657381
Smad signaling is required to maintain epigenetic silencing during breast cancer progression.Q39750283
Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapyQ39752287
Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: a pilot prognostic factor analysisQ41762709
Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.Q42824941
Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.Q46170702
Promoter-wide analysis of Smad4 binding sites in human epithelial cells.Q51564262
Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this diseaseQ54237738
Basis for natural resistance to methotrexate in human acute non-lymphocytic leukemiaQ67707958
The coding sequence mediates induction of 5-lipoxygenase expression by Smads3/4Q80139696
Identification and characterization of genetic variation in the folylpolyglutamate synthase geneQ81310207
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
P304page(s)9183-9198
P577publication date2014-10-01
P1433published inOncotargetQ1573155
P1476titleBinding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia
P478volume5

Reverse relations

cites work (P2860)
Q38821227Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance
Q39206549Identification of mutations, gene expression changes and fusion transcripts by whole transcriptome RNAseq in docetaxel resistant prostate cancer cells
Q90266353Single-Cell Transcriptomics Reveals Spatial and Temporal Turnover of Keratinocyte Differentiation Regulators
Q42728890miR-144-3p, a tumor suppressive microRNA targeting ETS-1 in laryngeal squamous cell carcinoma

Search more.