Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk

scientific article

Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.160911
P932PMC publication ID3048672
P698PubMed publication ID21209077

P2093author name stringQin Wang
John R Traynor
P2860cites workA heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimersQ24530081
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Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signalingQ28239433
Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the mu- and delta-opioid receptors regulate opioid receptor signalingQ28268819
N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cellsQ28283150
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunitsQ28286818
Morphine desensitization, internalization, and down-regulation of the mu opioid receptor is facilitated by serotonin 5-hydroxytryptamine2A receptor coactivationQ28290869
Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH‐SY5Y cellsQ28344890
Cellular regulation of RGS proteins: modulators and integrators of G protein signalingQ28646133
Proteasome involvement in agonist-induced down-regulation of mu and delta opioid receptorsQ31816606
Cannabinoid-opioid interactions during neuropathic pain and analgesiaQ33637224
RGS4 and RGS5 are in vivo substrates of the N-end rule pathwayQ34085136
Regulators of G-protein signalling as new central nervous system drug targets.Q34139169
Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependentQ34162653
Gi/o-coupled receptors compete for signaling to adenylyl cyclase in SH-SY5Y cells and reduce opioid-mediated cAMP overshootQ34701089
G protein independent phosphorylation and internalization of the delta-opioid receptorQ35212944
Isoforms of mammalian adenylyl cyclase: multiplicities of signalingQ35679436
Regulators of G protein signaling & drugs of abuse.Q36056317
Sensitization of adenylate cyclase by Galpha i/o-coupled receptorsQ36142386
Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studiesQ36741486
Signaling by internalized G-protein-coupled receptors.Q37715118
Ubiquitin, proteasomes, and the regulation of intracellular protein degradationQ40445002
Differentially Regulated Expression of Endogenous RGS4 and RGS7Q40618796
Region-specific regulation of RGS4 (Regulator of G-protein-signaling protein type 4) in brain by stress and glucocorticoids: in vivo and in vitro studiesQ40955606
delta- and mu-opioid receptor mobilization of intracellular calcium in SH-SY5Y human neuroblastoma cellsQ41249441
Demonstration of kappa 3-opioid receptors in the SH-SY5Y human neuroblastoma cell lineQ41328527
Adenylyl cyclase in SH-SY5Y human neuroblastoma cells is regulated by intra- and extracellular calcium.Q41343549
RGS4 is arginylated and degraded by the N-end rule pathway in vitroQ41732590
Stoichiometries of AMPA receptor subunit mRNAs in rat brain fall into discrete categoriesQ42444499
Physiological antagonism between ventricular beta 1-adrenoceptors and alpha 1-adrenoceptors but no evidence for beta 2- and beta 3-adrenoceptor function in murine heartQ42544516
Brain region specific actions of regulator of G protein signaling 4 oppose morphine reward and dependence but promote analgesiaQ42601949
Prolonged morphine treatment targets delta opioid receptors to neuronal plasma membranes and enhances delta-mediated antinociception.Q43744848
Up-regulation of RGS4 mRNA by opioid receptor agonists in PC12 cells expressing cloned mu- or kappa-opioid receptorsQ43832333
Abused drugs modulate RGS4 mRNA levels in rat brain: comparison between acute drug treatment and a drug challenge after chronic treatmentQ44149282
Up-regulation of regulator of G protein signaling 4 expression in a model of neuropathic pain and insensitivity to morphineQ44327442
Mu-opioid receptor desensitization: role of receptor phosphorylation, internalization, and representationQ44342223
Opioid receptors in human neuroblastoma SH-SY5Y cells: evidence for distinct morphine (mu) and enkephalin (delta) binding sitesQ44346951
Regulation of RGS proteins by chronic morphine in rat locus coeruleusQ44373732
Differential coupling of muscarinic receptors to Ca2+ mobilization and cyclic AMP in SH-SY5Y and IMR 32 neuroblastoma cellsQ44652721
Dopamine receptor-mediated regulation of RGS2 and RGS4 mRNA differentially depends on ascending dopamine projections and timeQ44847937
RGS4 inhibits Gq-mediated activation of mitogen-activated protein kinase and phosphoinositide synthesisQ46050875
Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatumQ48104056
Drug effects in a radial maze designed for dissociation of cues used by mice.Q52216974
Bradykinin-evoked release of [3H]noradrenaline from the human neuroblastoma SH-SY5Y.Q52871526
RGS Proteins Determine Signaling Specificity of Gq-coupled ReceptorsQ60687223
Identification of alpha 2-adrenergic receptor sites in human retinoblastoma (Y-79) and neuroblastoma (SH-SY5Y) cellsQ69331646
Muscarinic receptor binding characteristics of a human neuroblastoma SK-N-SH and its clones SH-SY5Y and SH-EP1Q69697029
Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Galphai and Galphao deactivation. Galpha specificity of RGS4 AND RGS7Q74172895
The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signalingQ77696554
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectopioidQ427523
protein ubiquitinationQ3547638
P304page(s)7854-7864
P577publication date2011-01-05
P1433published inJournal of Biological ChemistryQ867727
P1476titleOpioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk
P478volume286

Reverse relations

cites work (P2860)
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Q36573196Modulation of μ-Opioid Receptor Signaling by RGS19 in SH-SY5Y Cells
Q37279348Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP-dependent manner
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