Nox-4 deletion reduces oxidative stress and injury by PKC-α-associated mechanisms in diabetic nephropathy

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Nox-4 deletion reduces oxidative stress and injury by PKC-α-associated mechanisms in diabetic nephropathy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.14814/PHY2.12192
P932PMC publication ID4255803
P698PubMed publication ID25367693
P5875ResearchGate publication ID267762104

P50authorJosephine M. ForbesQ17517073
Melinda T CoughlanQ85508080
P2093author name stringHermann Haller
Harald H H W Schmidt
Mark E Cooper
David Barit
Jay C Jha
Karin A M Jandeleit-Dahm
Stephen P Gray
Vicki Thallas-Bonke
P2860cites workPost-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegenerationQ27323209
Free radicals in the physiological control of cell functionQ27860480
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiologyQ27860991
Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysisQ28216384
Aldose reductase in glucose toxicity: a potential target for the prevention of diabetic complicationsQ28268182
Oxidative stress as a major culprit in kidney disease in diabetesQ28281957
Subcellular localization of Nox4 and regulation in diabetesQ28566200
Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathwayQ28571271
Global estimates of the prevalence of diabetes for 2010 and 2030Q29547218
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damageQ29616101
The pathobiology of diabetic complications: a unifying mechanismQ29617766
Production and actions of superoxide in the renal medullaQ30662153
Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathyQ33660629
Advanced glycosylation end products in tissue and the biochemical basis of diabetic complicationsQ34049428
Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complicationsQ34287894
Roles of mitochondria in health and disease.Q35641708
NADPH oxidases in the kidneyQ36598811
Renal microvascular injury in diabetes: RAGE and redox signaling.Q36690238
Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathyQ37065902
RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes.Q37146417
Recent advances in pharmacotherapy for diabetic nephropathy: current perspectives and future directionsQ37475632
Nephropathy and elevated BP in mice with podocyte-specific NADPH oxidase 5 expressionQ37670311
Redox control of protein kinase C: cell- and disease-specific aspectsQ37688100
Nox as a target for diabetic complicationsQ38114488
Dual inhibition of classical protein kinase C-α and protein kinase C-β isoforms protects against experimental murine diabetic nephropathy.Q39349244
Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathyQ42970293
Preservation of kidney function with combined inhibition of NADPH oxidase and angiotensin-converting enzyme in diabetic nephropathy.Q43020318
Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy.Q43218267
Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: potential role in diabetic nephropathyQ44599806
Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product contentQ44633271
Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis.Q44953934
Effects of NADPH oxidase inhibitor in diabetic nephropathyQ46445328
Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4.Q46579574
Mesangial cell NADPH oxidase upregulation in high glucose is protein kinase C dependent and required for collagen IV expressionQ46677686
Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidneyQ46681131
Role of Nox4 in murine models of kidney disease.Q47430771
Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo.Q53589254
Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice.Q54574472
Combination Therapy with the Advanced Glycation End Product Cross-Link Breaker, Alagebrium, and Angiotensin Converting Enzyme Inhibitors in Diabetes: Synergy or Redundancy?Q61512804
Glycohemoglobin measured by automated affinity HPLC correlates with both short-term and long-term antecedent glycemiaQ72019101
A noninvasive computerized tail-cuff system for measuring blood pressure in miceQ72210808
Role of oxidative stress in diabetic complications: a new perspective on an old paradigmQ77804864
Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse modelQ79678201
Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in miceQ80305250
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectnitrogen oxideQ424418
P577publication date2014-11-03
P1433published inPhysiological ReportsQ15716763
P1476titleNox-4 deletion reduces oxidative stress and injury by PKC-α-associated mechanisms in diabetic nephropathy
P478volume2

Reverse relations

cites work (P2860)
Q63916411A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes
Q64100477AKF-PD alleviates diabetic nephropathy via blocking the RAGE/AGEs/NOX and PKC/NOX Pathways
Q52724019Acute Kidney Injury and Progression of Diabetic Kidney Disease.
Q62936515Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke
Q38758929Canonical Transient Receptor Potential 6 Channel: A New Target of Reactive Oxygen Species in Renal Physiology and Pathology
Q92545357Couplet medicines of leech and centipede granules improve erectile dysfunction via inactivation of the CaSR/PLC/PKC signaling in streptozotocin-induced diabetic rats
Q50092600Design, synthesis, and biological evaluation of inhibitors of the NADPH oxidase, Nox4.
Q37349206Diabetes and Kidney Disease: Role of Oxidative Stress
Q37597721Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury
Q92445964Flavin Oxidase-Induced ROS Generation Modulates PKC Biphasic Effect of Resveratrol on Endothelial Cell Survival
Q38785627Hydrogen Sulfide in Renal Physiology and Disease
Q46419349Hydrogen sulfide inhibits high glucose-induced NADPH oxidase 4 expression and matrix increase by recruiting inducible nitric oxide synthase in kidney proximal tubular epithelial cells
Q36464709Influence of protein kinase C (PKC) on the prognosis of diabetic nephropathy patients
Q46499634Interaction of PPARα With the Canonic Wnt Pathway in the Regulation of Renal Fibrosis
Q52680904Lipoxins Regulate the Early Growth Response-1 Network and Reverse Diabetic Kidney Disease.
Q41181776Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury
Q35824748Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors
Q28385322Obesity and Diabetic Kidney Disease: Role of Oxidant Stress and Redox Balance
Q92290748Oxidative Stress in the Pathogenesis and Evolution of Chronic Kidney Disease: Untangling Ariadne's Thread
Q47642456Oxidative stress induces renal failure: A review of possible molecular pathways.
Q54110304Pharmacological inhibition of the mitochondrial NADPH oxidase 4/PKCα/Gal-3 pathway reduces left ventricular fibrosis following myocardial infarction.
Q46648044Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy
Q98158779Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway
Q47231510Potein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes.
Q38701033Resveratrol ameliorates diabetic nephropathy in rats through negative regulation of the p38 MAPK/TGF-β1 pathway
Q35671828Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes
Q51210259The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age.
Q38883369Therapeutic angiogenesis by vascular endothelial growth factor supplementation for treatment of renal disease
Q46386818Tiron ameliorates high glucose-induced cardiac myocyte apoptosis by PKCδ-dependent inhibition of osteopontin
Q35450699Upstream regulators and downstream effectors of NADPH oxidases as novel therapeutic targets for diabetic kidney disease
Q92434021iTRAQ plasma proteomics analysis for candidate biomarkers of type 2 incipient diabetic nephropathy

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