Fibronectin and stem cell differentiation - lessons from chondrogenesis

scientific article

Fibronectin and stem cell differentiation - lessons from chondrogenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1242/JCS.095786
P932PMC publication ID3462078
P698PubMed publication ID22976308
P5875ResearchGate publication ID230849698

P2093author name stringJean E Schwarzbauer
Purva Singh
P2860cites workSoft substrates promote homogeneous self-renewal of embryonic stem cells via downregulating cell-matrix tractionsQ21091073
A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen geneQ24533335
The region encoded by the alternatively spliced exon IIIA in mesenchymal fibronectin appears essential for chondrogenesis at the level of cellular condensationQ73820517
Expression of N-cadherin, N-CAM, fibronectin and tenascin is stimulated by TGF-beta1, beta2, beta3 and beta5 during the formation of precartilage condensationsQ77356222
Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitroQ78313641
Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord bloodQ81428709
The promotion of chondrogenesis, osteogenesis, and adipogenesis of human mesenchymal stem cells by multiple growth factors incorporated into nanosphere-coated microspheresQ85102670
Fibronectin-mediated upregulation of α5β1 integrin and cell adhesion during differentiation of mouse embryonic stem cellsQ42598348
Lack of beta 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocystsQ42771254
Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytesQ42820082
Tenascin is a cytoadhesive extracellular matrix component of the human hematopoietic microenvironmentQ42953169
Defective proteoglycan sulfation of the growth plate zones causes reduced chondrocyte proliferation via an altered Indian hedgehog signalling.Q43062988
Cross-talk between alpha(4)beta(1)/alpha(5)beta(1) and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathwaysQ43550997
Role of cell shape in growth controlQ44152787
Type IX collagen gene expression during limb cartilage differentiationQ44320235
Differentiation of the human mesenchymal stem cells derived from bone marrow and enhancement of cell attachment by fibronectinQ46496575
Rho GTPases mediate the mechanosensitive lineage commitment of neural stem cellsQ46647615
Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethalityQ46917727
Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells (MSCs) in different hydrogels: influence of collagen type II extracellular matrix on MSC chondrogenesisQ46938265
Bone marrow-derived human mesenchymal stem cells become quiescent on soft substrates but remain responsive to chemical or mechanical stimuliQ47420367
Regulation and role of Sox9 in cartilage formation.Q47960826
Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesisQ48649327
In vitro derivation of chondrogenic cells from human embryonic stem cells.Q50721028
The detection of a precartilage, blastema-specific marker.Q50903697
Integrins regulate mouse embryonic stem cell self-renewal.Q50928305
Visualization of cartilage formation: insight into cellular properties of skeletal progenitors and chondrodysplasia syndromes.Q51984296
RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner.Q52022395
Fibronectin mRNA alternative splicing is temporally and spatially regulated during chondrogenesis in vivo and in vitro.Q52201337
Genetic ablation of Rac1 in cartilage results in chondrodysplasia.Q53556500
Laminin-1 induces neurite outgrowth in human mesenchymal stem cells in serum/differentiation factors-free conditions through activation of FAK-MEK/ERK signaling pathways.Q54710907
Changes in the patterns of collagens and fibronectin during limb-bud chondrogenesisQ67236077
Comparison between ectoderm-conditioned medium and fibronectin in their effects on chondrogenesis by limb bud mesenchymal cellsQ68509612
Fibronectin gene expression during limb cartilage differentiationQ69405889
A large chondroitin sulfate proteoglycan (PG-M) synthesized before chondrogenesis in the limb bud of chick embryoQ69620639
Quantitation of type II procollagen mRNA levels during chick limb cartilage differentiationQ69801480
The splicing pattern of fibronectin mRNA changes during chondrogenesis resulting in an unusual form of the mRNA in cartilageQ70119518
Association of focal adhesion kinase with fibronectin and paxillin is required for precartilage condensation of chick mesenchymal cellsQ73235449
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic nicheQ24600542
Developmental and pathogenic mechanisms of basement membrane assemblyQ24608109
The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerizationQ24644717
Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleatorsQ24645430
Substrate modulus directs neural stem cell behaviorQ24651892
Requirements for sulfate transport and the diastrophic dysplasia sulfate transporter in fibronectin matrix assemblyQ24684889
Matrix elasticity directs stem cell lineage specificationQ27860761
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone developmentQ28119185
Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalkQ28206345
Hereditary multiple exostoses and heparan sulfate polymerizationQ28213553
Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related geneQ28242642
Meet the tenascins: multifunctional and mysteriousQ28254352
Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitmentQ28255124
A diastrophic dysplasia sulfate transporter (SLC26A2) mutant mouse: morphological and biochemical characterization of the resulting chondrodysplasia phenotypeQ28306703
Pref-1 interacts with fibronectin to inhibit adipocyte differentiationQ28504692
SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouseQ28507337
SOX9 directly regulates the type-II collagen geneQ28512288
Global defects in collagen secretion in a Mia3/TANGO1 knockout mouseQ28586932
Sox9 is required for cartilage formationQ28588649
Mice deficient in Ext2 lack heparan sulfate and develop exostosesQ28592253
Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespanQ28593378
Loss of Sox9 function results in defective chondrocyte differentiation of mouse embryonic stem cells in vitroQ28593994
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblastsQ29547605
Defining the epithelial stem cell niche in skinQ29614985
Cell locomotion and focal adhesions are regulated by substrate flexibilityQ29615522
The extracellular matrix: not just pretty fibrilsQ29617251
Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectinQ29617865
Developmental regulation of the growth plateQ29618969
Fibronectins, their fibrillogenesis, and in vivo functionsQ30421926
Integrins and extracellular matrix in mechanotransductionQ30423615
Assembly of Fibronectin Extracellular MatrixQ30538938
Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrixQ33617497
Homing and mobilization in the stem cell niche.Q33650496
Laminin-5 induces osteogenic gene expression in human mesenchymal stem cells through an ERK-dependent pathwayQ33763894
Cellular interactions and signaling in cartilage developmentQ33916077
A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostosesQ33934484
The role of TGFbetas and Sox9 during limb chondrogenesisQ36627365
Endogenous production of fibronectin is required for self-renewal of cultured mouse embryonic stem cellsQ36638727
Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactionsQ36816992
Fibronectin- and collagen-mimetic ligands regulate bone marrow stromal cell chondrogenesis in three-dimensional hydrogelsQ37020597
Control of chondrogenesis by the transcription factor Sox9.Q37113764
Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stabilityQ37281591
Stem cell- and scaffold-based tissue engineering approaches to osteochondral regenerative medicineQ37512645
Activation and dedifferentiation of chondrocytes: implications in cartilage injury and repairQ37525586
Mesenchymal stem cells and cartilage in situ regenerationQ37599937
Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapy.Q37608619
Transcriptional networks controlling skeletal developmentQ37616352
Regulation of the chondrogenic phenotype in cultureQ37644373
Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes.Q37761694
The regulation of differentiation in mesenchymal stem cellsQ37784032
Fibronectin regulates proteoglycan production balance in transforming growth factor-β1-induced chondrogenesis.Q39493761
In vitro stage-specific chondrogenesis of mesenchymal stem cells committed to chondrocytesQ39889481
Modulation of stem cell shape and fate A: the role of density and seeding protocol on nucleus shape and gene expressionQ39942769
Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesisQ40119082
Versican/PG-M regulates chondrogenesis as an extracellular matrix molecule crucial for mesenchymal condensationQ40356687
Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1.Q40464537
RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis.Q40467439
Fibronectin matrix assembly regulates alpha5beta1-mediated cell cohesionQ40648245
Spatiotemporal patterns of fibronectin distribution during embryonic development. I. Chick limbsQ41617065
Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherinQ33961447
Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage.Q33964749
Versican facilitates chondrocyte differentiation and regulates joint morphogenesisQ33967118
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursorsQ34055618
Mesenchymal cell-based repair of large, full-thickness defects of articular cartilageQ34060569
Mutations in the diastrophic dysplasia sulfate transporter (DTDST) gene (SLC26A2): 22 novel mutations, mutation review, associated skeletal phenotypes, and diagnostic relevanceQ34176600
Cartilage proteoglycansQ34211749
Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tensionQ34221060
Interactions between cancer stem cells and their niche govern metastatic colonizationQ34239769
Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathwaysQ34421176
Functional analysis of fibronectin isoforms in chondrogenesis: Full-length recombinant mesenchymal fibronectin reduces spreading and promotes condensation and chondrogenesis of limb mesenchymal cellsQ34534794
Mesenchymal stem cell migration is regulated by fibronectin through α5β1-integrin-mediated activation of PDGFR-β and potentiation of growth factor signalsQ34727916
Vertebrate SkeletogenesisQ34800684
Laminin-511 but not -332, -111, or -411 enables mouse embryonic stem cell self-renewal in vitroQ34817133
Transcriptional control of skeletogenesisQ34820209
Molecular architecture and function of matrix adhesionsQ35006506
Reconstitution of marrow-derived extracellular matrix ex vivo: a robust culture system for expanding large-scale highly functional human mesenchymal stem cellsQ35082752
Enhanced MSC chondrogenesis following delivery of TGF-β3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivoQ35098667
Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondriumQ35106164
Preclinical studies on mesenchymal stem cell-based therapy for growth plate cartilage injury repairQ35130994
Dominance of SOX9 function over RUNX2 during skeletogenesisQ35539737
The haematopoietic stem cell niche at a glance.Q35548386
Expansion on extracellular matrix deposited by human bone marrow stromal cells facilitates stem cell proliferation and tissue-specific lineage potentialQ35578819
Overview of the matrisome--an inventory of extracellular matrix constituents and functionsQ35645897
Laminin-5 activates extracellular matrix production and osteogenic gene focusing in human mesenchymal stem cellsQ35751933
In vitro analysis of integrin expression in stem cells from bone marrow and cord blood during chondrogenic differentiationQ35832011
Microenvironmental changes during differentiation of mesenchymal stem cells towards chondrocytes.Q35869005
Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectinQ36148498
The loss of phenotypic traits by differentiated cells. 3. The reversible behavior of chondrocytes in primary culturesQ36187851
Collagen gene expression during limb cartilage differentiationQ36214737
Tenascin is associated with chondrogenic and osteogenic differentiation in vivo and promotes chondrogenesis in vitroQ36217281
Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiationQ36324592
Induction of chondrogenesis in limb mesenchymal cultures by disruption of the actin cytoskeletonQ36510296
What mouse mutants teach us about extracellular matrix function.Q36528815
P433issuePt 16
P407language of work or nameEnglishQ1860
P921main subjectstem cell differentiationQ14864672
cell differentiationQ210861
cartilage developmentQ5104524
P304page(s)3703-3712
P577publication date2012-08-01
P1433published inJournal of Cell ScienceQ1524177
P1476titleFibronectin and stem cell differentiation - lessons from chondrogenesis
P478volume125

Reverse relations

cites work (P2860)
Q551900762D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling.
Q36253842A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption
Q96816764Atelocollagen promotes chondrogenic differentiation of human adipose-derived mesenchymal stem cells
Q41809016Biological and MRI characterization of biomimetic ECM scaffolds for cartilage tissue regeneration.
Q54296515Cartilage differentiation in ependymoma: histogenetic considerations on a new case.
Q60912967Cell number in mesenchymal stem cell aggregates dictates cell stiffness and chondrogenesis
Q42508447Chondrogenesis and hypertrophy in response to aggregate behaviors of human mesenchymal stem cells on a dendrimer-immobilized surface
Q38803441Collaboration of fibronectin matrix with other extracellular signals in morphogenesis and differentiation
Q48357501Concise Review: Translating Regenerative Biology into Clinically Relevant Therapies: Are We on the Right Path?
Q35144762Dkk-1 and IL-7 in plasma of patients with multiple myeloma prevent differentiation of mesenchymal stem cells into osteoblasts
Q38834896Double compartmented and hybrid implant outfitted with well-organized 3D stem cells for osteochondral regenerative nanomedicine
Q37050849Enhancement of Matrix Metalloproteinase-2 (MMP-2) as a Potential Chondrogenic Marker during Chondrogenic Differentiation of Human Adipose-Derived Stem Cells
Q37634215Enhancement of tenogenic differentiation of human adipose stem cells by tendon-derived extracellular matrix.
Q39030766Environmental preconditioning rejuvenates adult stem cells' proliferation and chondrogenic potential
Q54563200Establishment and characterization of human engineered cells stably expressing large extracellular matrix proteins.
Q35892672Extracellular Protease Inhibition Alters the Phenotype of Chondrogenically Differentiating Human Mesenchymal Stem Cells (MSCs) in 3D Collagen Microspheres
Q53690396Fibronectin Promotes the Malignancy of Glioma Stem-Like Cells Via Modulation of Cell Adhesion, Differentiation, Proliferation and Chemoresistance.
Q51785150Fibronectin facilitates EV71 infection by mediating its entry.
Q42142730Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration
Q30592327Fibronectin matrix assembly is essential for cell condensation during chondrogenesis
Q33670843Gene expression profile in human induced pluripotent stem cells: Chondrogenic differentiation in vitro, part A
Q58577518Genetic Markers Can Predict Chondrogenic Differentiation Potential in Bone Marrow-Derived Mesenchymal Stromal Cells
Q55221300Genetic abrogation of the fibronectin-α5β1 integrin interaction in articular cartilage aggravates osteoarthritis in mice.
Q92702999Hemmule: A Novel Structure with the Properties of the Stem Cell Niche
Q36554905Heterogeneous Differentiation of Human Mesenchymal Stem Cells in 3D Extracellular Matrix Composites
Q38206794Illustrating the interplay between the extracellular matrix and microRNAs.
Q47879350In Vitro Expression of the Extracellular Matrix Components Aggrecan, Collagen Types I and II by Articular Cartilage-Derived Chondrocytes
Q35078827In vitro augmentation of mesenchymal stem cells viability in stressful microenvironments : In vitro augmentation of mesenchymal stem cells viability
Q58190258Integrin signaling in cartilage development
Q37071280Isolation and characterization of multipotent mesenchymal stem cells in nasal polyps
Q51655139Living scaffolds: surgical repair using scaffolds seeded with human adipose-derived stem cells.
Q90555796Mechanistic insights into the cellular effects of a novel FN1 variant associated with a spondylometaphyseal dysplasia
Q38527565Microenvironmental factors involved in human amnion mesenchymal stem cells fate decisions
Q35739722Modulating Mesenchymal Stem Cell Behavior Using Human Hair Keratin-Coated Surfaces
Q46113995Mutations in Fibronectin Cause a Subtype of Spondylometaphyseal Dysplasia with "Corner Fractures".
Q34231330Nanocomposite scaffold for chondrocyte growth and cartilage tissue engineering: effects of carbon nanotube surface functionalization
Q35622533Novel insights into the function and dynamics of extracellular matrix in liver fibrosis
Q30627162PDGF‑stimulated dispersal of cell clusters and disruption of fibronectin matrix on three-dimensional collagen matrices requires matrix metalloproteinase-2.
Q42800060Particle size influences fibronectin internalization and degradation by fibroblasts
Q55513002Pericellular collagen I coating for enhanced homing and chondrogenic differentiation of mesenchymal stem cells in direct intra-articular injection.
Q50671633Physioxia Promotes the Articular Chondrocyte-Like Phenotype in Human Chondroprogenitor-Derived Self-Organized Tissue.
Q36088714Plasma-Derived Fibronectin Stimulates Chondrogenic Differentiation of Human Subchondral Cortico-Spongious Progenitor Cells in Late-Stage Osteoarthritis
Q53623402Platelet-rich plasma scaffolds for tissue engineering: more than just growth factors in three dimensions.
Q36532532Proteomic analysis of integrin-associated complexes from mesenchymal stem cells
Q39110850Recent advances in hydrogels for cartilage tissue engineering
Q47218182Recombinant Extracellular Matrix Protein fragments Support Human Embryonic Stem Cell Chondrogenesis
Q48131930Self-assembled nanofiber coatings for controlling cell responses.
Q41534186Serum fibronectin distinguishes the early stages of hepatocellular carcinoma
Q38754115Spatially Assembled Bilayer Cell Sheets of Stem Cells and Endothelial Cells Using Thermosensitive Hydrogels for Therapeutic Angiogenesis.
Q47595752Strategies to retain properties of bone marrow-derived mesenchymal stem cells ex vivo
Q48943815Tendon-Derived Extracellular Matrix Enhances Transforming Growth Factor-β3-Induced Tenogenic Differentiation of Human Adipose-Derived Stem Cells
Q24311563The changing integrin expression and a role for integrin β8 in the chondrogenic differentiation of mesenchymal stem cells
Q38154828The effect of non-growth factors on chondrogenic differentiation of mesenchymal stem cells
Q38321523The importance of extracellular matrix for cell function and in vivo likeness.
Q38289876The role of growth factors in stem cell-directed chondrogenesis: a real hope for damaged cartilage regeneration
Q47131423Three Dimensional Honeycomb Patterned Fibrinogen Based Nanofibers Induce Substantial Osteogenic Response of Mesenchymal Stem Cells
Q37494622Three-dimensional scaffold-free fusion culture: the way to enhance chondrogenesis of in vitro propagated human articular chondrocytes.
Q34984424Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering Tie2 expression

Search more.