The expression and regulation of matrix metalloproteinase-3 is critically modulated by Porphyromonas gingivalis lipopolysaccharide with heterogeneous lipid A structures in human gingival fibroblasts

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The expression and regulation of matrix metalloproteinase-3 is critically modulated by Porphyromonas gingivalis lipopolysaccharide with heterogeneous lipid A structures in human gingival fibroblasts is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1013784355
P356DOI10.1186/1471-2180-13-73
P932PMC publication ID3623786
P698PubMed publication ID23548063
P5875ResearchGate publication ID236099166

P2093author name stringYu Wang
Cun-Yu Wang
Chaminda J Seneviratne
Richard P Darveau
Lijian Jin
Thanuja D K Herath
P2860cites workTLR signaling pathwaysQ24570127
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Porphyromonas gingivalis affects host collagen degradation by affecting expression, activation, and inhibition of matrix metalloproteinases.Q50481635
Is collagen breakdown during periodontitis linked to inflammatory cells and expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gingival tissue?Q52051943
Sustained activation of the mitogen-activated protein kinase pathway. A mechanism underlying receptor tyrosine kinase specificity for matrix metalloproteinase-9 induction and cell migration.Q52533773
Macrophage-induced expression and release of matrix metalloproteinase 1 and 3 by human preadipocytes is mediated by IL-1β via activation of MAPK signaling.Q54558251
Differential modulation of human β-defensins expression in human gingival epithelia by Porphyromonas gingivalis lipopolysaccharide with tetra- and penta-acylated lipid A structuresQ59317415
Matrix metalloproteinases, their physiological inhibitors and osteoclast factors are differentially regulated by the cytokine profile in human periodontal diseaseQ60681898
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Immunophenotypic analysis of human gingival fibroblasts and its regulation by Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)Q73470134
Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathwaysQ74230888
Tissue inhibitors of metalloproteinases level and collagenase activity in gingival crevicular fluid: the relevance to periodontal diseasesQ77316393
TLR signalingQ79715393
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Influence of LPS, TNF, TGF-�1 and IL-4 on the expression of MMPs, TIMPs and selected cytokines in rat synovial membranes incubated in vitroQ82419946
Porphyromonas gingivalis LPS stimulates the expression of LPS-binding protein in human oral keratinocytes in vitroQ84465792
Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissueQ94679726
Inflammatory responses of gingival epithelial cells stimulated with Porphyromonas gingivalis vesicles are inhibited by hop-associated polyphenolsQ94679729
MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progressionQ30519569
Expression of a Porphyromonas gingivalis lipid A palmitylacyltransferase in Escherichia coli yields a chimeric lipid A with altered ability to stimulate interleukin-8 secretionQ33230005
Hemin-dependent modulation of the lipid A structure of Porphyromonas gingivalis lipopolysaccharideQ33251439
Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalisQ34010067
Matrix turnoverQ34094562
Interactions of adiponectin and lipopolysaccharide from Porphyromonas gingivalis on human oral epithelial cellsQ34154641
The keystone-pathogen hypothesis.Q34297138
Effects of hyaluronan treatment on lipopolysaccharide-challenged fibroblast-like synovial cellsQ35769032
Matrix metalloproteinases (MMPs) in oral diseases.Q35943087
Lipopolysaccharide heterogeneity: innate host responses to bacterial modification of lipid a structure.Q36171584
Porphyromonas gingivalis-epithelial cell interactions in periodontitisQ36457270
Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation.Q36580334
The role of matrix metalloproteinases in the oral environmentQ36758426
Insights into the regulation of protein abundance from proteomic and transcriptomic analysesQ36846022
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IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activationQ38297511
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Microbial complexes in subgingival plaqueQ38553206
Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity differentially modulates the expression of IL-6 and IL-8 in human gingival fibroblasts.Q39507447
Global oral health inequalities: task group--periodontal diseaseQ39760929
Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4.Q40014914
Longitudinal evaluation of GCF MMP-3 and TIMP-1 levels as prognostic factors for progression of periodontitisQ40712222
Effects of treatment on gingival crevicular collagenase, stromelysin and tissue inhibitor of metalloproteinases and their ability to predict response to treatmentQ40950577
Fibroblast heterogeneity in the periodontium and other tissuesQ41402269
Porphyromonas gingivalis lipopolysaccharide induces shedding of syndecan-1 expressed by gingival epithelial cellsQ42472808
Inhibition of matrix metalloproteinase-3 synthesis in human conjunctival fibroblasts by interleukin-4 or interleukin-13.Q42497391
EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathways.Q42509418
Induction of metalloproteinases expression by TLR ligands in human fibroblast like synoviocytes from juvenile idiopathic arthritis patientsQ43008535
Proinflammatory effects of muramyldipeptide on human gingival fibroblastsQ43063240
Role of nuclear factor-kappa B activation in metalloproteinase-1, -3, and -9 secretion by human macrophages in vitro and rabbit foam cells produced in vivoQ43989973
Signal pathways involved in the production of MMP-1 and MMP-3 in human gingival fibroblastsQ44121738
Activation of MMP-2 by Porphyromonas gingivalis in human periodontal ligament cellsQ44331687
Mouthrinses with alcohol: cytotoxic effects on human gingival fibroblasts in vitroQ44484046
Prostaglandin E2 regulates interleukin-1beta-induced matrix metalloproteinase-3 production in human gingival fibroblastsQ44774875
Interleukin-1beta induces matrix metalloproteinase-1 expression in cultured human gingival fibroblasts: role of cyclooxygenase-2 and prostaglandin E2.Q44783594
The bacteria of periodontal diseasesQ45112663
Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasoneQ48333589
Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration.Q48515308
Discordance of prolactin gene transcription, mRNA storage, and hormone release in individual mammotropesQ48776861
IL-8 and IDO expression by human gingival fibroblasts via TLRsQ50074511
Endotoxin-induced early gene expression in C3H/HeJ (Lpsd) macrophages.Q50147145
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectlipopolysaccharideQ421804
Porphyromonas gingivalisQ3214147
P304page(s)73
P577publication date2013-03-30
P1433published inBMC MicrobiologyQ15759430
P1476titleThe expression and regulation of matrix metalloproteinase-3 is critically modulated by Porphyromonas gingivalis lipopolysaccharide with heterogeneous lipid A structures in human gingival fibroblasts
P478volume13

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cites work (P2860)
Q48156176Compromised inflammatory cytokine response to P. gingivalis LPS by fibroblasts from inflamed human gingiva
Q40731921Effect of glycated albumin and cranberry components on interleukin-6 and matrix metalloproteinase-3 production by human gingival fibroblasts
Q37188987Heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts
Q34885481Hydrogen sulphide decreases IL-1β-induced activation of fibroblast-like synoviocytes from patients with osteoarthritis.
Q53704723Importance of heterogeneity in Porhyromonas gingivalis lipopolysaccharide lipid A in tissue specific inflammatory signalling.
Q35909892Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts
Q92408958Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors
Q51345216Porphyromonas gingivalis Lipopolysaccharide Induces a Pro-inflammatory Human Gingival Fibroblast Phenotype.
Q37363914Zebrafish as a new model to study effects of periodontal pathogens on cardiovascular diseases.

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