Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial

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Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial is …
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scholarly articleQ13442814

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P356DOI10.1016/S1473-3099(13)70033-1
P698PubMed publication ID23499158

P50authorNezam AfdhalQ60650815
K. Rajender ReddyQ69932454
Mark SulkowskiQ89653950
Kris V. KowdleyQ110296712
P2093author name stringAndrew Muir
David R Nelson
Hongmei Mo
Ira M Jacobson
Ming Lin
Natalie H Bzowej
Douglas T Dieterich
Maribel Rodriguez-Torres
Michael Mader
William T Symonds
Efsevia Albanis
Tarek Hassanein
Donald Jensen
Eric Lawitz
Robert H Hyland
Bradley Freilich
Edwin Dejesus
David E Bernstein
Gary A Abrams
Jama M Darling
Robert Hindes
Aasim M Sheikh
Michelle M Berrey
Fred F Poordad
Jay P Lalezari
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Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assayQ27469483
Development of Intergenotypic Chimeric Replicons To Determine the Broad-Spectrum Antiviral Activities of Hepatitis C Virus Polymerase InhibitorsQ27487022
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infectionQ27860901
Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin doseQ29547886
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PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replicationQ34045444
EASL Clinical Practice Guidelines: management of hepatitis C virus infectionQ34168383
Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C.Q34320498
Peginterferon and ribavirin for chronic hepatitis C.Q36675912
Protease inhibitors for the treatment of chronic hepatitis C genotype-1 infection: the new standard of careQ38014646
New pharmacotherapy for hepatitis C.Q38031097
Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virusQ39376758
Recent successes and noteworthy future prospects in the treatment of chronic hepatitis C.Q39599595
Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infectionQ42989510
P433issue5
P921main subjectliver cirrhosisQ147778
ribavirinQ421862
sofosbuvirQ2502747
hepatitis CQ154869
patientQ181600
peginterferon alfa-2aQ420056
phase II clinical trialQ42824440
P304page(s)401-408
P577publication date2013-03-15
P1433published inLancet Infectious DiseasesQ15724248
P1476titleSofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial
P478volume13