Multiple roles of the extracellular vestibule amino acid residues in the function of the rat P2X4 receptor

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Multiple roles of the extracellular vestibule amino acid residues in the function of the rat P2X4 receptor is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...859411R
P356DOI10.1371/JOURNAL.PONE.0059411
P932PMC publication ID3605439
P698PubMed publication ID23555667
P5875ResearchGate publication ID236106521

P50authorMilos RokicQ59687585
Vendula TvrdonovaQ59707085
P2093author name stringHana Zemkova
Pavlo Kuzyk
Stanko S Stojilkovic
Vojtech Vavra
P2860cites workHistidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zincQ24306094
ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4Q24311307
P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channelsQ24533248
Molecular and functional properties of P2X receptors--recent progress and persisting challengesQ24617046
Ion access pathway to the transmembrane pore in P2X receptor channelsQ24629121
Mechanism of ivermectin facilitation of human P2X4 receptor channelsQ24644507
Polar residues in the second transmembrane domain of the rat P2X2 receptor that affect spontaneous gating, unitary conductance, and rectificationQ24648191
Crystal structure of the ATP-gated P2X(4) ion channel in the closed stateQ24657193
Molecular mechanism of ATP binding and ion channel activation in P2X receptorsQ27678739
Allosteric control of gating and kinetics at P2X(4) receptor channelsQ28142880
Molecular physiology of P2X receptorsQ28203477
Identification of a non-canonical tyrosine-based endocytic motif in an ionotropic receptorQ28213523
Signaling at purinergic P2X receptorsQ28296741
Gain and loss of channel function by alanine substitutions in the transmembrane segments of the rat ATP-gated P2X2 receptorQ28564289
Identification of an intersubunit cross-link between substituted cysteine residues located in the putative ATP binding site of the P2X1 receptorQ28569271
A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptorsQ33601789
Gated access to the pore of a P2X receptor: structural implications for closed-open transitions.Q33744436
Neuromodulation by extracellular ATP and P2X receptors in the CNS.Q33781729
Identification of P2X4 receptor-specific residues contributing to the ivermectin effects on channel deactivationQ34562779
Structural Insights into the Function of P2X4: An ATP-Gated Cation Channel of Neuroendocrine CellsQ34588858
Regulation of P2X4 receptors by lysosomal targeting, glycan protection and exocytosisQ34701623
Activation and regulation of purinergic P2X receptor channelsQ35122793
Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors).Q35170819
Allosteric modulation of Ca2+ flux in ligand-gated cation channel (P2X4) by actions on lateral portalsQ35801949
Gating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulationsQ35837037
Cysteine substitution mutants give structural insight and identify ATP binding and activation sites at P2X receptorsQ36166147
Acidic amino acids impart enhanced Ca2+ permeability and flux in two members of the ATP-gated P2X receptor familyQ36295984
Pathophysiology and therapeutic potential of purinergic signalingQ36409590
Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channelsQ36412653
Contribution of extracellular negatively charged residues to ATP action and zinc modulation of rat P2X2 receptorsQ36951788
Purinergic regulation of hypothalamopituitary functionsQ37397335
An antagonist-insensitive P2X receptor expressed in epithelia and brainQ38362921
Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gatingQ38673214
Functional relevance of aromatic residues in the first transmembrane domain of P2X receptorsQ39854925
On the role of the first transmembrane domain in cation permeability and flux of the ATP-gated P2X2 receptorQ40042581
An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideumQ40108297
Participation of the Lys313-Ile333 sequence of the purinergic P2X4 receptor in agonist binding and transduction of signals to the channel gateQ40235376
Contribution of transmembrane regions to ATP-gated P2X2 channel permeability dynamicsQ40489469
Contribution of calcium ions to P2X channel responses.Q40571393
P2X receptor trafficking in neurons is subunit specific.Q40723365
Amino acid residues involved in gating identified in the first membrane-spanning domain of the rat P2X(2) receptorQ40816581
Pore dilation of neuronal P2X receptor channelsQ40960421
Identification of amino acid residues contributing to the pore of a P2X receptorQ41106961
Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds.Q41646184
Zinc enhances long-term potentiation through P2X receptor modulation in the hippocampal CA1 regionQ42972142
ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonistsQ44709204
Contribution of conserved glycine residues to ATP action at human P2X1 receptors: mutagenesis indicates that the glycine at position 250 is important for channel functionQ46762841
Contribution of conserved polar glutamine, asparagine and threonine residues and glycosylation to agonist action at human P2X1 receptors for ATP.Q46863050
Facilitation of glutamate and GABA release by P2X receptor activation in supraoptic neurons from freshly isolated rat brain slices.Q54372782
Identification of Amino Acid Residues Contributing to the ATP-binding Site of a Purinergic P2X ReceptorQ56828299
Ethanol inhibition of adenosine 5'-triphosphate-activated current in freshly isolated adult rat hippocampal CA1 neuronsQ73222592
Glycine rescue of β-sheets from cis-prolineQ84990063
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)e59411
P577publication date2013-03-21
P1433published inPLOS OneQ564954
P1476titleMultiple roles of the extracellular vestibule amino acid residues in the function of the rat P2X4 receptor
P478volume8

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cites work (P2860)
Q35920298Allosteric regulation of the P2X4 receptor channel pore dilation
Q34295303Basolateral P2X₄channels stimulate ENaC activity in Xenopus cortical collecting duct A6 cells
Q34514344Identification of functionally important residues of the rat P2X4 receptor by alanine scanning mutagenesis of the dorsal fin and left flipper domains
Q26771359Insights into the channel gating of P2X receptors from structures, dynamics and small molecules
Q47611830Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin
Q38273638Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis
Q39390185P2X Receptor Activation
Q33718454P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology.
Q34509716Plasma membrane cholesterol as a regulator of human and rodent P2X7 receptor activation and sensitization
Q35587851Roles of the lateral fenestration residues of the P2X₄ receptor that contribute to the channel function and the deactivation effect of ivermectin
Q37526362Structural and functional properties of the rat P2X4 purinoreceptor extracellular vestibule during gating.

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