Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer.

scientific article

Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2013/541695
P932PMC publication ID3736531
P698PubMed publication ID23970932
P5875ResearchGate publication ID256086122

P50authorSung-Liang YuQ56523487
Ya-Chien YangQ61877006
P2093author name stringChun-Chieh Chen
Huei-Wen Chen
Qi-Sheng Hong
Jen-Yi Lee
Yu-Shuang Lin
Munisamy Sureshbabul
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Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesisQ24610450
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Signaling through focal adhesion kinaseQ28198051
Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: the versatile adjuvant for gefitinib therapyQ34000044
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Kisspeptin-10, a KISS1-derived decapeptide, inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF expression and FAK/Rho GTPase activationQ35622038
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New concepts regarding focal adhesion kinase promotion of cell migration and proliferationQ36528648
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The cell-cell adhesion molecule E-cadherin.Q37251750
Curcumin inhibits cellular condensation and alters microfilament organization during chondrogenic differentiation of limb bud mesenchymal cellsQ37366494
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Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.Q37712330
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Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma.Q38313564
The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activityQ38320163
Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line.Q38340102
CD24 controls Src/STAT3 activity in human tumors.Q39320370
CD24 interacts with and promotes the activity of c-src within lipid rafts in breast cancer cells, thereby increasing integrin-dependent adhesionQ39516801
Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin.Q39671761
Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1.Q39939558
Sp1 is required for transforming growth factor-beta-induced mesenchymal transition and migration in pancreatic cancer cellsQ40169686
Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factorsQ40171554
Down-regulation of overexpressed sp1 protein in human fibrosarcoma cell lines inhibits tumor formation.Q40459609
The level of a transcription factor Sp1 is correlated with the expression of EGF receptor in human gastric carcinomasQ41588849
Potential anticancer activity of turmeric (Curcuma longa).Q42229848
Curcumin attenuates aluminum-induced oxidative stress and mitochondrial dysfunction in rat brainQ42732590
Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contactsQ42827824
Curcumin blocks migration and invasion of mouse-rat hybrid retina ganglion cells (N18) through the inhibition of MMP-2, -9, FAK, Rho A and Rock-1 gene expressionQ43176545
Anti-tumour and antioxidant activity of natural curcuminoidsQ43522706
FAK overexpression upregulates cyclin D3 and enhances cell proliferation via the PKC and PI3-kinase-Akt pathwaysQ44394215
The C-terminal domain of focal adhesion kinase reduces the tumor cell invasiveness in chondrosarcoma cell lines.Q44614675
Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.Q52180037
CD24 mediates rolling of breast carcinoma cells on P-selectin.Q55067929
Focal adhesion kinase is not essential for in vitro and in vivo differentiation of ES cellsQ72182145
Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma cellsQ73334936
Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinomaQ73894010
E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivationQ74620595
Loss of E-cadherin promotes the growth, invasion and drug resistance of colorectal cancer cells and is associated with liver metastasisQ83396650
Curcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cellsQ85215191
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectcolorectal cancerQ188874
curcuminQ312266
P304page(s)541695
P577publication date2013-07-21
P1433published inEvidence-based Complementary and Alternative MedicineQ5418319
P1476titleCurcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
P478volume2013

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