Multiply damaged sites in DNA: interactions with Escherichia coli endonucleases III and VIII

scientific article

Multiply damaged sites in DNA: interactions with Escherichia coli endonucleases III and VIII is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/26.4.932
P932PMC publication ID147348
P698PubMed publication ID9461450

P50authorSusan S WallaceQ41886664
P2093author name stringL Harrison
Z Hatahet
A A Purmal
P2860cites workEscherichia coli endonuclease III is not an endonuclease but a beta-elimination catalystQ24529420
DNA strand breaks, repair, and survival in x-irradiated mammalian cellsQ24617104
Processing of DNA base damage by DNA polymerases. Dihydrothymine and beta-ureidoisobutyric acid as models for instructive and noninstructive lesionsQ28334662
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodGQ29616532
Repair of oxidative damage to DNA: enzymology and biologyQ29618065
DNA polymerase III holoenzyme: structure and function of a chromosomal replicating machineQ34058015
DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparabilityQ34164868
gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate terminiQ34270825
Initial events in the cellular effects of ionizing radiations: clustered damage in DNA.Q34321951
Abasic site binding by the human apurinic endonuclease, Ape, and determination of the DNA contact sitesQ34626537
A novel method for site specific introduction of single model oxidative DNA lesions into oligodeoxyribonucleotidesQ34978281
Escherichia coli endonuclease VIII: cloning, sequencing, and overexpression of the nei structural gene and characterization of nei and nei nth mutantsQ35624116
X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elutionQ35760000
Thymine glycol lesions terminate chain elongation by DNA polymerase I in vitroQ36089095
Sequence dependence for bypass of thymine glycols in DNA by DNA polymerase IQ36089478
Radiation and hydrogen peroxide induced free radical damage to DNA.Q36290881
Refined solution structure of a DNA heteroduplex containing an aldehydic abasic siteQ36681696
The role of DNA double strand breaks in lonizing radiation-induced killing of eukaryotic cellsQ36952860
Exonuclease III and endonuclease IV remove 3' blocks from DNA synthesis primers in H2O2-damaged Escherichia coliQ37403076
Enzymatic induction of DNA double-strand breaks in gamma-irradiated Escherichia coli K-12Q37458577
Endonuclease III interactions with DNA substrates. 1. Binding and footprinting studies with oligonucleotides containing a reduced apyrimidinic siteQ38298460
Reactivity of human apurinic/apyrimidinic endonuclease and Escherichia coli exonuclease III with bistranded abasic sites in DNA.Q38344891
Chemical changes induced in DNA by ionizing radiation.Q39499333
Major oxidative products of cytosine, 5-hydroxycytosine and 5-hydroxyuracil, exhibit sequence context-dependent mispairing in vitro.Q40398133
Multiple DNA repair activities for 3'-deoxyribose fragments in Escherichia coliQ40520762
Rejoining of gamma-radiation-induced single-strand breaks in plasmid DNA by human cell extracts: dependence on the concentration of the hydroxyl radical scavenger, TrisQ41256593
DNA base damage in chromatin of gamma-irradiated cultured human cellsQ41647398
New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-Q42283571
Purification and characterization of Escherichia coli endonuclease III from the cloned nth geneQ42644821
8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutionsQ44480509
Effect of apurinic/apyrimidinic endonucleases and polyamines on DNA treated with bleomycin and neocarzinostatin: specific formation and cleavage of closely opposed lesions in complementary strandsQ44994750
Neocarzinostatin-induced DNA base release accompanied by staggered oxidative cleavage of the complementary strandQ45075242
Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaksQ47411906
Formation of an 8-hydroxyguanine moiety in deoxyribonucleic acid on gamma-irradiation in aqueous solution.Q53742363
Processing of model single-strand breaks in phi X-174 RF transfecting DNA by Escherichia coli.Q54386327
Translesional synthesis on DNA templates containing a single abasic site. A mechanistic study of the "A rule".Q54565641
Isolation and characterization of endonuclease VIII from Escherichia coli.Q54640652
Thymine ring saturation and fragmentation products: lesion bypass, misinsertion and implications for mutagenesis.Q54658619
Radiation-induced DNA damage and its repair.Q54766327
Characterization ofEscherichia coliEndonuclease VIIIQ62061105
The role of specific DNA base damages in the X-ray-induced inactivation of bacteriophage PM2Q62061136
The action of Escherichia coli endonuclease III on multiply damaged sites in DNAQ64389553
DNA Double-strand Breaks Generated by the Repair of X-ray Damage in Chinese Hamster CellsQ64390678
The crosslinking of nuclear protein to DNA using ionizing radiationQ68897674
Functional effects of cis-thymine glycol lesions on DNA synthesis in vitroQ69441225
Insertion of nucleotides opposite apurinic/apyrimidinic sites in deoxyribonucleic acid during in vitro synthesis: uniqueness of adenine nucleotidesQ70288775
DNA glycosylase activities for thymine residues damaged by ring saturation, fragmentation, or ring contraction are functions of endonuclease III in Escherichia coliQ70339723
Molecular dynamics simulations of the effects of ring‐saturated thymine lesions on DNA structureQ72110191
Mechanism of bypass synthesis through an abasic site analog by DNA polymerase IQ73106783
Structure of a duplex DNA containing a thymine glycol residue in solutionQ73182586
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectEscherichia coliQ25419
P304page(s)932-941
P577publication date1998-02-01
P1433published inNucleic Acids ResearchQ135122
P1476titleMultiply damaged sites in DNA: interactions with Escherichia coli endonucleases III and VIII
P478volume26

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cites work (P2860)
Q38302579A possible role of Ku in mediating sequential repair of closely opposed lesions
Q50074327A significant role of non-thermal equilibrated electrons in the formation of deleterious complex DNA damage.
Q36309404Abortive base-excision repair of radiation-induced clustered DNA lesions in Escherichia coli
Q33892600Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease.
Q38734778Base Excision Repair of N6-Deoxyadenosine Adducts of 1,3-Butadiene
Q34710048Biological consequences of free radical-damaged DNA bases.
Q34662405Can DNA repair cause enhanced cell killing following treatment with ionizing radiation?
Q33832767Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair
Q41883369Characterization of class II apurinic/apyrimidinic endonuclease activities in the human malaria parasite, Plasmodium falciparum
Q38317916Closely opposed apurinic/apyrimidinic sites are converted to double strand breaks in Escherichia coli even in the absence of exonuclease III, endonuclease IV, nucleotide excision repair and AP lyase cleavage
Q34366796Clustered DNA damage induced by gamma radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites
Q38313262Clustered DNA damage, influence on damage excision by XRS5 nuclear extracts and Escherichia coli Nth and Fpg proteins
Q37142830Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation
Q35026374Dynamics and diversions in base excision DNA repair of oxidized abasic lesions
Q34338741Endogenous DNA damage clusters in human skin, 3-D model, and cultured skin cells
Q40695070Enhanced mutagenic potential of 8-oxo-7,8-dihydroguanine when present within a clustered DNA damage site
Q34255624Enzymatic processing of DNA containing tandem dihydrouracil by endonucleases III and VIII.
Q35026369Enzymology of the repair of free radicals-induced DNA damage
Q39229629Evaluation of phosphodiesterase I-based protocols for the detection of multiply damaged sites in DNA: the detection of abasic, oxidative and alkylative tandem damage in DNA oligonucleotides
Q38660216Excision of 8-oxoguanine within clustered damage by the yeast OGG1 protein
Q36185059FANCD2 influences replication fork processes and genome stability in response to clustered DSBs
Q40675131Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells
Q34390795Free radical-induced double lesions in DNA.
Q43825657Frequencies and relative levels of clustered damages in DNA exposed to gamma rays in radioquenching vs. nonradioquenching conditions
Q37247774Going ape as an approach to cancer therapeutics
Q44441831HU Protein of Escherichia coli Has a Role in the Repair of Closely Opposed Lesions in DNA
Q33888410High efficiency detection of bi-stranded abasic clusters in gamma-irradiated DNA by putrescine
Q36649692Human abasic endonuclease action on multilesion abasic clusters: implications for radiation-induced biological damage
Q40592819Human and rodent cell lines showing no differences in the induction but differing in the repair kinetics of radiation-induced DNA base damage
Q46211304Induction of single strand breaks, and base lesions in plasmid DNA films induced by carbon, nitrogen, and oxygen KLL Auger process
Q35865301Interplay between DNA N-glycosylases/AP lyases at multiply damaged sites and biological consequences
Q35120818Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture
Q35868826Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation
Q35804057Mechanism of radiosensitization by hyperthermia (> or = 43 degrees C) as derived from studies with DNA repair defective mutant cell lines
Q44273176Mode of inhibition of short-patch base excision repair by thymine glycol within clustered DNA lesions
Q36181711New insights on cell death from radiation exposure
Q36781044Non-problematic risks from low-dose radiation-induced DNA damage clusters
Q33931095Nucleosomes suppress the formation of double-strand DNA breaks during attempted base excision repair of clustered oxidative damages
Q24793953Processing of a complex multiply damaged DNA site by human cell extracts and purified repair proteins
Q40773113Processing of clustered DNA damage generates additional double-strand breaks in mammalian cells post-irradiation
Q41825528Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic
Q34651984Radiation damage to DNA: the importance of track structure
Q35591791Role of isolated and clustered DNA damage and the post-irradiating repair process in the effects of heavy ion beam irradiation
Q34330588Securing genome stability by orchestrating DNA repair: removal of radiation-induced clustered lesions in DNA.
Q44280413Sorting the consequences of ionizing radiation: processing of 8-oxoguanine/abasic site lesions
Q73715158The abasic site as a target for generation of locally multiply damaged sites
Q37099942The transition of closely opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1.
Q33839295XRCC1 keeps DNA from getting stranded