DNMT3A Mutational Status Affects the Results of Dose-Escalated Induction Therapy in Acute Myelogenous Leukemia

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DNMT3A Mutational Status Affects the Results of Dose-Escalated Induction Therapy in Acute Myelogenous Leukemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-14-0327
P932PMC publication ID4383675
P698PubMed publication ID25609058

P50authorSelina LugerQ90053593
Alison Wakoff LorenQ90758423
P2093author name stringJianhua Zhao
Martin Carroll
Phyllis A Gimotty
Robert Daber
Jennifer D Morrissette
Jing-Mei Hsu
Alison R Sehgal
P2860cites workConversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1Q24316558
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarateQ24605258
Recurring mutations found by sequencing an acute myeloid leukemia genomeQ24634204
DNMT3A Mutations in Acute Myeloid LeukemiaQ27559610
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemiaQ27851430
ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic categoryQ27851679
Prognostic relevance of integrated genetic profiling in acute myeloid leukemiaQ27851726
Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG).Q27852247
Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group StudyQ28139696
Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)Q28209814
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemiaQ29615735
Mutation in TET2 in myeloid cancersQ29619292
Understanding the limitations of next generation sequencing informatics, an approach to clinical pipeline validation using artificial data setsQ30757355
The role of mutations in epigenetic regulators in myeloid malignanciesQ34033164
High-dose daunorubicin in older patients with acute myeloid leukemiaQ34612117
Anthracycline dose intensification in acute myeloid leukemiaQ34612121
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemiaQ34627568
Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemiaQ34630212
Prognostic impact of DNMT3A mutations in patients with intermediate cytogenetic risk profile acute myeloid leukemiaQ34632784
Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French AssociationQ34635511
Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemiaQ35717852
Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implicationsQ37827283
DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cellsQ39703300
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.Q43102402
Randomized study of intensified anthracycline doses for induction and recombinant interleukin-2 for maintenance in patients with acute myeloid leukemia age 50 to 70 years: results of the ALFA-9801 studyQ43202683
Landmark analysis of DNMT3A mutations in hematological malignanciesQ44744267
Randomized study of individualized induction therapy with or without vincristine, and of maintenance-intensification therapy between 4 or 12 courses in adult acute myeloid leukemia. AML-87 Study of the Japan Adult Leukemia Study GroupQ70753024
Randomized trials between behenoyl cytarabine and cytarabine in combination induction and consolidation therapy, and with or without ubenimex after maintenance/intensification therapy in adult acute myeloid leukemia. The Japan Leukemia Study GroupQ70891287
No beneficial effect from addition of etoposide to daunorubicin, cytarabine, and 6-mercaptopurine in individualized induction therapy of adult acute myeloid leukemia: the JALSG-AML92 study. Japan Adult Leukemia Study GroupQ73021186
Treating the elderly patient with acute myelogenous leukemiaQ83217262
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
P304page(s)1614-1620
P577publication date2015-01-21
P1433published inClinical Cancer ResearchQ332253
P1476titleDNMT3A Mutational Status Affects the Results of Dose-Escalated Induction Therapy in Acute Myelogenous Leukemia
P478volume21

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