B-RafV600E inhibits sodium iodide symporter expression via regulation of DNA methyltransferase 1

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B-RafV600E inhibits sodium iodide symporter expression via regulation of DNA methyltransferase 1 is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1030515515
P356DOI10.1038/EMM.2014.68
P932PMC publication ID4261912
P698PubMed publication ID25378232
P5875ResearchGate publication ID267931481

P2093author name stringHyun-Ju Kim
So Hyun Park
Young Hwa Kim
Euy Young Soh
Jang-Hee Kim
Jeonghun Lee
Yong Won Choi
Tae Jun Park
Yong Jun Chwae
P2860cites workGlobal cancer statisticsQ22241238
The sodium/iodide Symporter (NIS): characterization, regulation, and medical significanceQ28209900
DNMT1 and DNMT3b cooperate to silence genes in human cancer cellsQ28212826
The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancerQ28262702
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancerQ29614277
DNA methylation, methyltransferases, and cancerQ30993657
Molecular pathogenesis and mechanisms of thyroid cancerQ34329018
BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancerQ34560988
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activationQ35578577
The sodium iodide symporter (NIS): regulation and approaches to targeting for cancer therapeuticsQ36128415
BRAF mutation in thyroid cancerQ36157661
Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemiaQ36445921
Increased iodine uptake in thyroid carcinoma after treatment with sodium butyrate and decitabine (5-Aza-dC).Q40060705
Protein synthesis inhibitors, in synergy with 5-azacytidine, restore sodium/iodide symporter gene expression in human thyroid adenoma cell line, KAK-1, suggesting trans-active transcriptional repressorQ40197347
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cellsQ40559173
Methylation levels of sodium-iodide symporter (NIS) promoter in benign and malignant thyroid tumors with reduced NIS expressionQ46316325
BRAFV600E mutation, but not RET/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancerQ46570559
BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesisQ46778071
Iodide symporter gene expression in human thyroid tumorsQ47856134
Changing trends and prognoses for patients with papillary thyroid cancer.Q50860524
DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas.Q53348394
Thyroid-specific gene expression in the multi-step process of thyroid carcinogenesis.Q53421611
Suppression of BRAF/MEK/MAP kinase pathway restores expression of iodide-metabolizing genes in thyroid cells expressing the V600E BRAF mutant.Q53569559
Analysis of differential BRAF(V600E) mutational status in high aggressive papillary thyroid microcarcinoma.Q54505841
The BRAF Mutation Is Predictive of Aggressive Clinicopathological Characteristics in Papillary Thyroid MicrocarcinomaQ54642091
The oncogene BRAFV600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I− targeting to the membraneQ60559931
BRAF Mutations in Papillary Thyroid Carcinomas Inhibit Genes Involved in Iodine MetabolismQ61951314
BRAFV600E promotes invasiveness of thyroid cancer cells through nuclear factor kappaB activationQ64377520
Human thyrotropin receptor gene: expression in thyroid tumors and correlation to markers of thyroid differentiation and dedifferentiationQ67802417
The mRNA levels of thyrotropin receptor, thyroglobulin and thyroid peroxidase in neoplastic human thyroid tissuesQ68201396
Analysis of thyroid carcinoma based on material registered in Japan during 1977-1986 with special reference to predominance of papillary typeQ68234122
Expression of thyroid-specific transcription factors TTF-1 and PAX-8 in human thyroid neoplasmsQ72132796
Restoration of iodide uptake in dedifferentiated thyroid carcinoma: relationship to human Na+/I-symporter gene methylation statusQ77997569
Molecular characteristics in papillary thyroid cancers (PTCs) with no 131I uptakeQ81248210
Expression of iodine metabolism genes in human thyroid tissues: evidence for age and BRAFV600E mutation dependencyQ81797099
P275copyright licenseCreative Commons Attribution-NonCommercial-ShareAlike 3.0 UnportedQ15643954
P6216copyright statuscopyrightedQ50423863
P304page(s)e120
P577publication date2014-11-07
P1433published inExperimental and Molecular MedicineQ15758292
P1476titleB-RafV600E inhibits sodium iodide symporter expression via regulation of DNA methyltransferase 1
P478volume46

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cites work (P2860)
Q98290370Appraisal of radioiodine refractory thyroid cancer: advances and challenges
Q89543466DNA methylation alterations as therapeutic prospects in thyroid cancer
Q90575227LncRNA LUCAT1 as a novel prognostic biomarker for patients with papillary thyroid cancer
Q39934112MicroRNAs let7 expression in thyroid cancer: correlation with their deputed targets HMGA2 and SLC5A5.
Q38758800NADPH Oxidase NOX4 Is a Critical Mediator of BRAFV600E-Induced Downregulation of the Sodium/Iodide Symporter in Papillary Thyroid Carcinomas.
Q104135085Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma
Q92432285THE ASSOCIATION BETWEEN LYMPH NODE METASTASIS AND MOLECULAR MARKERS IN DIFFERENTIATED THYROID CANCER
Q92286795Targeting the BRAF Signaling Pathway in CD133pos Cancer Stem Cells of Anaplastic Thyroid Carcinoma

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