The large intestine as a major reservoir for simian immunodeficiency virus in macaques with long-term, nonprogressing infection

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The large intestine as a major reservoir for simian immunodeficiency virus in macaques with long-term, nonprogressing infection is …
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scholarly articleQ13442814

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P356DOI10.1086/657413
P8608Fatcat IDrelease_l6amneupmjf5xitmhipasbta64
P932PMC publication ID3058301
P698PubMed publication ID21050120
P5875ResearchGate publication ID47677751

P2093author name stringAndrew A Lackner
Preston A Marx
Ronald S Veazey
Lara A Doyle
Mahesh Mohan
Linda C Green
Binhua Ling
P2860cites workLow-level CD4+ T cell activation is associated with low susceptibility to HIV-1 infectionQ81375635
Immune reconstitution in the sigmoid colon after long-term HIV therapyQ82949871
CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractQ22242965
Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tractQ22242981
Microbial translocation is a cause of systemic immune activation in chronic HIV infectionQ22251054
HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cellsQ22251066
Immune activation and inflammation in HIV-1 infection: causes and consequencesQ22252860
Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infectionQ29619099
Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infectionQ29619124
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferationQ29619611
Lack of mucosal immune reconstitution during prolonged treatment of acute and early HIV-1 infectionQ33265482
Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDSQ33676630
Gastrointestinal T lymphocytes retain high potential for cytokine responses but have severe CD4(+) T-cell depletion at all stages of simian immunodeficiency virus infection compared to peripheral lymphocytesQ33783560
Lack of decay of HIV-1 in gut-associated lymphoid tissue reservoirs in maximally suppressed individualsQ34561005
Mechanisms involved in non-progressive HIV diseaseQ35687036
Gastrointestinal disease in simian immunodeficiency virus-infected rhesus macaques is characterized by proinflammatory dysregulation of the interleukin-6-Janus kinase/signal transducer and activator of transcription3 pathwayQ36202888
Compartmentalization of the gut viral reservoir in HIV-1 infected patientsQ36412750
Immunopathogenesis of acute AIDS virus infectionQ36497211
Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapyQ36541079
Monitoring alpha4beta7 integrin expression on circulating CD4+ T cells as a surrogate marker for tracking intestinal CD4+ T-cell loss in SIV infection.Q36985448
Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapyQ37033224
Modeling HIV persistence, the latent reservoir, and viral blipsQ37365718
Alpha4(+)beta7(hi)CD4(+) memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection.Q37390603
SIV(mac) pathogenesis in rhesus macaques of Chinese and Indian origin compared with primary HIV infections in humansQ39182178
Identifying the target cell in primary simian immunodeficiency virus (SIV) infection: highly activated memory CD4(+) T cells are rapidly eliminated in early SIV infection in vivoQ39588498
Dynamics of CCR5 expression by CD4(+) T cells in lymphoid tissues during simian immunodeficiency virus infectionQ39597678
Studies in subjects with long-term nonprogressive human immunodeficiency virus infectionQ44369963
Rapid mucosal CD4(+) T-cell depletion and enteropathy in simian immunodeficiency virus-infected rhesus macaquesQ45749820
Early restoration of mucosal CD4 memory CCR5 T cells in the gut of SIV-infected rhesus predicts long term non-progression.Q51969581
HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term non-progressorsQ61473239
Characterization of gut-associated lymphoid tissue (GALT) of normal rhesus macaquesQ73162671
Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapyQ77890124
Gut microbes out of control in HIV infectionQ79412046
How HIV guts the immune systemQ81327246
The intestinal mucosa as a reservoir of HIV-1 infection after successful HAARTQ81332835
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectSimian immunodeficiency virusQ1890246
P304page(s)1846-1854
P577publication date2010-11-04
P1433published inJournal of Infectious DiseasesQ4051141
P1476titleThe large intestine as a major reservoir for simian immunodeficiency virus in macaques with long-term, nonprogressing infection
P478volume202

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