Identification of a live attenuated vaccine candidate for tularemia prophylaxis

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Identification of a live attenuated vaccine candidate for tularemia prophylaxis is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...861539M
P356DOI10.1371/JOURNAL.PONE.0061539
P932PMC publication ID3629233
P698PubMed publication ID23613871
P5875ResearchGate publication ID236277811

P50authorDennis W. MetzgerQ38323275
Meenakshi MalikQ42134300
P2093author name stringSukalyani Banik
Chandra Shekhar Bakshi
Seham M Rabadi
Manish Mahawar
Sally V Catlett
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A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challengeQ33346284
Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacyQ33725674
Tularemia as a biological weapon: medical and public health managementQ33949367
Francisella tularensis antioxidants harness reactive oxygen species to restrict macrophage signaling and cytokine productionQ34107159
Development of functional and molecular correlates of vaccine-induced protection for a model intracellular pathogen, F. tularensis LVS.Q34139968
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A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccineQ34194818
Low dose vaccination with attenuated Francisella tularensis strain SchuS4 mutants protects against tularemia independent of the route of vaccinationQ34291236
Generation and characterization of an attenuated mutant in a response regulator gene of Francisella tularensis live vaccine strain (LVS).Q34307145
Cellular and humoral immunity are synergistic in protection against types A and B Francisella tularensisQ34423341
Tularemia: history, epidemiology, pathogen physiology, and clinical manifestationsQ34613846
Th17 cytokines in recall responses against Francisella tularensis in humans.Q51045525
[Tularemia, a potential bioterrorism weapon]Q73882925
Studies on tularemia. V. Immunization of manQ75603973
Mice vaccinated with the O-antigen of Francisella tularensis LVS lipopolysaccharide conjugated to bovine serum albumin develop varying degrees of protective immunity against systemic or aerosol challenge with virulent type A and type B strains of thQ77148368
Studies with tularemia vaccines in volunteers. IV. Brucella aggiutinins in vaccinated and nonvaccinated volunteers challenged with Pasteurella tularensisQ79015693
Transcriptional profiling of host responses in mouse lungs following aerosol infection with type A Francisella tularensisQ82545647
BALB/c mice, but not C57BL/6 mice immunized with a ΔclpB mutant of Francisella tularensis subspecies tularensis are protected against respiratory challenge with wild-type bacteria: association of protection with post-vaccination and post-challenge iQ83831171
Construction and characterization of an attenuated purine auxotroph in a Francisella tularensis live vaccine strainQ34975711
Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensisQ35009321
Superoxide dismutase B gene (sodB)-deficient mutants of Francisella tularensis demonstrate hypersensitivity to oxidative stress and attenuated virulenceQ35075325
Cell-mediated and humoral immune responses after vaccination of human volunteers with the live vaccine strain of Francisella tularensisQ35224151
In vivo negative selection screen identifies genes required for Francisella virulenceQ35699734
Vaccines against Francisella tularensis--past, present and futureQ35791781
Tularemia: the disease and the weaponQ35810776
Oral immunization of mice with the live vaccine strain (LVS) of Francisella tularensis protects mice against respiratory challenge with virulent type A F. tularensisQ35910851
Genome-wide identification of Francisella tularensis virulence determinantsQ35913441
Identification of a novel Francisella tularensis factor required for intramacrophage survival and subversion of innate immune responseQ36127190
Identification of Francisella tularensis outer membrane protein A (FopA) as a protective antigen for tularemia.Q36191199
Identification of immunologic and pathologic parameters of death versus survival in respiratory tularemia.Q36421591
Francisella tularensis vaccinesQ36742723
Native outer membrane proteins protect mice against pulmonary challenge with virulent type A Francisella tularensis.Q36804275
Toxicity of Pasteurella tularensis killed by ionizing radiationQ36850093
An improved vaccine for prevention of respiratory tularemia caused by Francisella tularensis SchuS4 strainQ37120769
Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challengeQ37132733
T cells from lungs and livers of Francisella tularensis-immune mice control the growth of intracellular bacteriaQ37191318
Utilization of Fc receptors as a mucosal vaccine strategy against an intracellular bacterium, Francisella tularensisQ37209029
Safety, reactogenicity and immunogenicity of Francisella tularensis live vaccine strain in humansQ37305453
Attenuation and protective efficacy of an O-antigen-deficient mutant of Francisella tularensis LVS.Q40085788
Prophylactic and therapeutic use of antibodies for protection against respiratory infection with Francisella tularensisQ40117823
Aerogenic immunization of man with live Tularemia vaccineQ40720507
Identification of Francisella tularensis live vaccine strain CuZn superoxide dismutase as critical for resistance to extracellularly generated reactive oxygen speciesQ42134257
Recent studies on live tularemia vaccineQ46496352
Virulence of Bacterium tularense. I. A study of the virulence of Bacterium tularense in mice, guinea pigs, and rabbitsQ46720788
Responsiveness to acidity via metal ion regulators mediates virulence in the gastric pathogen Helicobacter pylori.Q47261526
Phase variation in Francisella tularensis affecting intracellular growth, lipopolysaccharide antigenicity and nitric oxide productionQ50139093
Role of lipopolysaccharide and a major outer membrane protein from Francisella tularensis in the induction of immunity against tularemiaQ50142489
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectattenuated vaccineQ1810913
P304page(s)e61539
P577publication date2013-04-17
P1433published inPLOS OneQ564954
P1476titleIdentification of a live attenuated vaccine candidate for tularemia prophylaxis
P478volume8

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cites work (P2860)
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