The second transmembrane domain of P2X7 contributes to dilated pore formation

scientific article

The second transmembrane domain of P2X7 contributes to dilated pore formation is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2013PLoSO...861886S
P356DOI10.1371/JOURNAL.PONE.0061886
P932PMC publication ID3629090
P698PubMed publication ID23613968
P5875ResearchGate publication ID236277908

P50authorPeter A KeyelQ88462362
Russell D SalterQ115679024
P2093author name stringChengqun Sun
Michelle E Heid
P2860cites workThe inflammasomesQ24304087
Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptorQ24306745
Crystal structure of the ATP-gated P2X(4) ion channel in the closed stateQ24657193
Direct observation of ATP-induced conformational changes in single P2X(4) receptorsQ27330359
A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptorQ28142246
Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired functionQ28188667
Molecular physiology of P2X receptorsQ28203477
An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptorQ28209495
Synaptic terminals from mice midbrain exhibit functional P2X7 receptorQ28504863
The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)Q28568856
Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complexQ30479449
Human P2X7 pore function predicts allele linkage disequilibrium.Q50733683
Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatmentQ59056598
Nonselective cationic currents elicited by extracellular ATP in human B-lymphocytesQ71698449
A domain contributing to the ion channel of ATP-gated P2X2 receptors identified by the substituted cysteine accessibility methodQ74315052
A polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosisQ79344934
The P2X7 ATP receptor in the kidney: a matter of life or death?Q81799352
Gated access to the pore of a P2X receptor: structural implications for closed-open transitions.Q33744436
Visualizing chromatin and chromosomes in living cellsQ34172290
Pore-opening mechanism in trimeric P2X receptor channelsQ34313783
P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartateQ34568867
Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic actionQ35089854
Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channelsQ36412653
Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processesQ36448740
Molecular probes for P2X7 receptor studiesQ36855448
The nucleotide receptor P2RX7 mediates ATP-induced CREB activation in human and murine monocytic cellsQ36882305
Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channelsQ36954596
The inflammasome: a danger sensing complex triggering innate immunityQ36989115
Gating the pore of P2X receptor channelsQ37069023
C terminus of the P2X7 receptor: treasure hunting.Q37864114
Identification and characterization of a novel variant of the human P2X(7) receptor resulting in gain of functionQ39600810
Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding.Q39971174
On the role of the first transmembrane domain in cation permeability and flux of the ATP-gated P2X2 receptorQ40042581
Characterization of ionotrophic purinergic receptors in hepatocytesQ40047618
Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteinsQ40070137
Tumor-suppressive effects of pannexin 1 in C6 glioma cells.Q40169694
A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophagesQ40355682
N-methyl-D-glucamine and propidium dyes utilize different permeation pathways at rat P2X(7) receptorsQ40386629
Contribution of transmembrane regions to ATP-gated P2X2 channel permeability dynamicsQ40489469
P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal regionQ40681894
Rapid secretion of interleukin-1beta by microvesicle sheddingQ40765816
Amino acid residues involved in gating identified in the first membrane-spanning domain of the rat P2X(2) receptorQ40816581
Pore dilation of neuronal P2X receptor channelsQ40960421
Identification of amino acid residues contributing to the pore of a P2X receptorQ41106961
Establishment of a cell line with features of early dendritic cell precursors from fetal mouse skinQ41316011
Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds.Q41646184
Residues 155 and 348 contribute to the determination of P2X7 receptor function via distinct mechanisms revealed by single-nucleotide polymorphismsQ42650027
Two haplotypes of the P2X(7) receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1beta secretionQ43111624
The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta releaseQ43122222
Involvement of P2X7 receptors in the hypoxia-induced death of rat retinal neuronsQ43195177
Regulation of P2X(7) nucleotide receptor function in human monocytes by extracellular ions and receptor densityQ43540365
P2X7 nucleotide receptor mediation of membrane pore formation and superoxide generation in human promyelocytes and neutrophilsQ43612851
P2X(7) receptors in the enteric nervous system of guinea-pig small intestineQ43824584
P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemiaQ43847756
Cell-specific behavior of P2X7 receptors in mouse parotid acinar and duct cellsQ44580828
P2X7 receptors in rat brain: presence in synaptic terminals and granule cells.Q44626268
A loss-of-function polymorphism in the human P2X7 receptor abolishes ATP-mediated killing of mycobacteria.Q44649133
Extracellular ATP increases cation fluxes in human erythrocytes by activation of the P2X7 receptorQ45013845
P2X7 receptor channels allow direct permeation of nanometer-sized dyes.Q45529200
Extracellular ATP induces cytokine expression and apoptosis through P2X7 receptor in murine mast cellsQ46391153
Gene dosage determines the negative effects of polymorphic alleles of the P2X7 receptor on adenosine triphosphate-mediated killing of mycobacteria by human macrophages.Q46534191
Glutamate release and synapsin-I phosphorylation induced by P2X7 receptors activation in cerebellar granule neuronsQ46776877
Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptorQ46973315
Adenosine triphosphate-induced shedding of CD23 and L-selectin (CD62L) from lymphocytes is mediated by the same receptor but different metalloproteases.Q47781603
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecttransmembrane proteinQ424204
P304page(s)e61886
P577publication date2013-04-17
P1433published inPLOS OneQ564954
P1476titleThe second transmembrane domain of P2X7 contributes to dilated pore formation
P478volume8

Reverse relations

cites work (P2860)
Q36863566Comparative study of the P2X gene family in animals and plants
Q41355158Functional characterization of mutants in the transmembrane domains of the rat P2X7 receptor that regulate pore conductivity and agonist sensitivity.
Q42114347High-frequency voltage oscillations in cultured astrocytes
Q30313395Localization of the gate and selectivity filter of the full-length P2X7 receptor
Q47242164N-terminal tagging of human P2X7 receptor disturbs calcium influx and dye uptake.
Q36417661P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2.
Q55266660Purinergic Receptors in Neurological Diseases With Motor Symptoms: Targets for Therapy.
Q35095632Role of P2X purinoceptor 7 in neurogenic pulmonary edema after subarachnoid hemorrhage in rats
Q37684086Structural and molecular modeling features of P2X receptors
Q26851893Two open states of P2X receptor channels

Search more.