Multiple mechanisms mediate resistance to sorafenib in urothelial cancer

scientific article

Multiple mechanisms mediate resistance to sorafenib in urothelial cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/IJMS151120500
P932PMC publication ID4264180
P698PubMed publication ID25387078
P5875ResearchGate publication ID268228475

P50authorJudith KnievelQ63968650
Annemarie GreifeQ93105553
Günter NiegischQ42869865
Wolfgang A. SchulzQ38326200
P2093author name stringIngo Schmitz
Peter Albers
Christiane Hader
Tobias Lübke
P2860cites workExpression of VEGF and its receptors VEGFR1/VEGFR2 is associated with invasiveness of bladder cancer.Q50922886
A new and reliable culture system for superficial low-grade urothelial carcinoma of the bladder.Q51023679
The expression of vascular endothelial growth factor in transitional cell carcinoma of urinary bladder is correlated with cancer progression.Q51032175
FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma.Q52857898
EAU guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2013 guidelines.Q54391399
The raf inhibitor paradox: unexpected consequences of targeted drugs.Q54687011
Significance of urinary epidermal growth factor and its receptor expression in human bladder cancerQ73311092
Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatmentQ80673261
Stress-activated kinase pathway alteration is a frequent event in bladder cancerQ39431237
Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levelsQ39556740
The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenibQ39662629
Stimulatory effects of the multi-kinase inhibitor sorafenib on human bladder cancer cellsQ39677393
Expression and clinical significance of hepaCAM and VEGF in urothelial carcinomaQ39686307
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survivalQ39761203
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.Q40192837
The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006.Q40399567
Decreased Fas expression in advanced-stage bladder cancer is not related to p53 statusQ40588270
The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifierQ42773975
The multikinase inhibitor Sorafenib induces apoptosis and sensitises endometrial cancer cells to TRAIL by different mechanisms.Q43195406
Prospective randomized double-blind multicentre phase II study comparing gemcitabine and cisplatin plus sorafenib chemotherapy with gemcitabine and cisplatin plus placebo in locally advanced and/or metastasized urothelial cancer: SUSE (AUO-AB 31/05)Q43718098
Expression signature of E2F1 and its associated genes predict superficial to invasive progression of bladder tumorsQ43823457
Expression and significance of vascular endothelial growth factor receptor 2 in bladder cancerQ43844968
Activities of MAP-kinase pathways in normal uroepithelial cells and urothelial carcinoma cell linesQ44254660
A phase II trial of sorafenib in first-line metastatic urothelial cancer: a study of the PMH Phase II ConsortiumQ44951549
Prevalence of KIT expression in human tumorsQ45150110
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregationQ45823928
Autocrine regulation of human urothelial cell proliferation and migration during regenerative responses in vitroQ46476362
Inhibition of death receptor signals by cellular FLIPQ24316446
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008Q27860674
The role of c-FLIP in modulation of CD95-induced apoptosisQ28293167
Comprehensive molecular characterization of urothelial bladder carcinomaQ28306864
c-FLIP, a master anti-apoptotic regulatorQ28391119
S6K1 and 4E-BP1 are independent regulated and control cellular growth in bladder cancerQ28477972
An inhibitor of Bcl-2 family proteins induces regression of solid tumoursQ29547595
Towards a knowledge-based Human Protein AtlasQ29617987
Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapyQ33572016
Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006)Q35607396
The role of c-FLIP splice variants in urothelial tumours.Q35657114
Proteins of the bcl-2 family in apoptosis signalling: from mechanistic insights to therapeutic opportunities.Q35685794
Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent processQ36057887
Understanding urothelial carcinoma through cancer pathwaysQ36430266
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.Q36610990
Bladder cancer cells acquire competent mechanisms to escape Fas-mediated apoptosis and immune surveillance in the course of malignant transformationQ36622253
Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cellsQ36742203
Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activationQ36922674
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activationQ37172903
Bladder cancer subtypes defined by genomic alterationsQ37278990
Phase 2 trial of sorafenib in patients with advanced urothelial cancer: a trial of the Eastern Cooperative Oncology GroupQ37415341
Targeting c-FLICE-like inhibitory protein (CFLAR) in cancerQ38068479
Two death pathways induced by sorafenib in myeloma cells: Puma-mediated apoptosis and necroptosis.Q38974167
Targeted polytherapy in small cell sarcoma and its association with doxorubicinQ38977714
Limited efficacy of specific HDAC6 inhibition in urothelial cancer cells.Q39016475
Genomic characterization of three urinary bladder cancer cell lines: understanding genomic types of urinary bladder cancerQ39031180
Inhibition of autophagy significantly enhances combination therapy with sorafenib and HDAC inhibitors for human hepatoma cellsQ39206134
HDAC inhibitors synergize antiproliferative effect of sorafenib in renal cell carcinoma cells.Q39306394
Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independentQ39431199
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)20500-20517
P577publication date2014-11-07
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleMultiple mechanisms mediate resistance to sorafenib in urothelial cancer
P478volume15

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cites work (P2860)
Q38672966Antiangiogenic tyrosine kinase inhibitors in colorectal cancer: is there a path to making them more effective?
Q36413738Combinatorial high-throughput experimental and bioinformatic approach identifies molecular pathways linked with the sensitivity to anticancer target drugs
Q47212126Combined inhibition of BET proteins and class I HDACs synergistically induces apoptosis in urothelial carcinoma cell lines.
Q55254546Cyclooxygenase inhibitors potentiate receptor tyrosine kinase therapies in bladder cancer cells in vitro.
Q89494101Efficacy and Safety of Chemotherapy Regimens in Advanced or Metastatic Bladder and Urothelial Carcinomas: An Updated Network Meta-Analysis
Q50182584Epigenetic Treatment Options in Urothelial Carcinoma
Q30489412Evaluation of the Therapeutic Potential of the Novel Isotype Specific HDAC Inhibitor 4SC-202 in Urothelial Carcinoma Cell Lines.
Q26745320Modulation of Autophagy by Sorafenib: Effects on Treatment Response
Q64259068Precision medicine review: rare driver mutations and their biophysical classification
Q35998718Safety and efficacy of combination therapy with low-dose gemcitabine, paclitaxel, and sorafenib in patients with cisplatin-resistant urothelial cancer
Q38534167Targeting the VEGF pathway in metastatic bladder cancer
Q53787748[Resistance to anti-angiogenic therapy: a clinical and scientific current issue].

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