A phase I study of continuous infusion cilengitide in patients with solid tumors

scientific article published on September 14, 2010

A phase I study of continuous infusion cilengitide in patients with solid tumors is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1026588476
P356DOI10.1007/S10637-010-9537-9
P953full work available at URLhttps://europepmc.org/articles/pmc3059335?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20839028/pdf/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20839028/?tool=EBI
https://europepmc.org/articles/PMC3059335
https://europepmc.org/articles/PMC3059335?pdf=render
https://doi.org/10.1007/s10637-010-9537-9
https://link.springer.com/content/pdf/10.1007/s10637-010-9537-9.pdf
https://link.springer.com/article/10.1007/s10637-010-9537-9/fulltext.html
http://link.springer.com/content/pdf/10.1007/s10637-010-9537-9
P932PMC publication ID3059335
P698PubMed publication ID20839028
P5875ResearchGate publication ID46256954

P50authorMark J RatainQ87725760
P2093author name stringLinda Janisch
Peter H. O'Donnell
Walter M. Stadler
M. Kelly Nicholas
Samir D. Undevia
Theodore M. Karrison
P2860cites workBiochimica et Biophysica ActaQ864239
Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signalingQ46158906
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinomaQ46837791
Kinetic analysis of integrin-dependent cell adhesion on vitronectin--the inhibitory potential of plasminogen activator inhibitor-1 and RGD peptidesQ47881843
Phase II Evaluations of Cilengitide in Asymptomatic Patients with Androgen-Independent Prostate Cancer: Scientific Rationale and Study DesignQ57714784
Cilengitide targeting of alpha(v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenograftsQ28216709
Signalling via integrins: implications for cell survival and anticancer strategiesQ28272370
Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vesselsQ29619679
N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonistsQ30580638
A randomized multi-center phase II trial of the angiogenesis inhibitor Cilengitide (EMD 121974) and gemcitabine compared with gemcitabine alone in advanced unresectable pancreatic cancerQ33265964
Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma.Q33375093
Synergy between an antiangiogenic integrin alphav antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases.Q34756781
Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiformeQ34871632
Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins αvβ3 and αvβ5 in patients with advanced solid tumoursQ40592751
Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonistQ43517798
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)604-610
P577publication date2010-09-14
P1433published inInvestigational New DrugsQ2312231
P1476titleA phase I study of continuous infusion cilengitide in patients with solid tumors
P478volume30

Reverse relations

cites work (P2860)
Q92970937Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment
Q35111316Cilengitide inhibits attachment and invasion of malignant pleural mesothelioma cells through antagonism of integrins αvβ3 and αvβ5.
Q37230631Combating resistance to anti-IGFR antibody by targeting the integrin β3-Src pathway
Q36719621In vitro and in vivo drug disposition of cilengitide in animals and human
Q36020955Insulin-like growth factor binding protein-3 inhibits cell adhesion via suppression of integrin β4 expression
Q41670949Integrins as Therapeutic Targets: Successes and Cancers.
Q35365860Iodine-125-labeled cRGD-gold nanoparticles as tumor-targeted radiosensitizer and imaging agent
Q93007229Modulating Tumor Cell Functions by Tunable Nanopatterned Ligand Presentation
Q37548974Pharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells
Q46894458Population pharmacokinetics of cilengitide in adult and pediatric cancer patients from a nonlinear mixed-effects analysis
Q36368035Serum C-Telopeptide Collagen Crosslinks and Plasma Soluble VEGFR2 as Pharmacodynamic Biomarkers in a Trial of Sequentially Administered Sunitinib and Cilengitide
Q104795035Targeting TGFβ signal transduction for cancer therapy