The pentostatin plus cyclophosphamide nonmyeloablative regimen induces durable host T cell functional deficits and prevents murine marrow allograft rejection

scientific article

The pentostatin plus cyclophosphamide nonmyeloablative regimen induces durable host T cell functional deficits and prevents murine marrow allograft rejection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBMT.2010.11.029
P932PMC publication ID3061246
P698PubMed publication ID21130889
P5875ResearchGate publication ID49657622

P2093author name stringJustin Taylor
Daniel H Fowler
Paul R Massey
Miriam E Mossoba
Shoba Amarnath
Tania C Felizardo
Jason Foley
Jacopo Mariotti
Kaitlyn Ryan
Nicole Buxhoeveden
P2860cites workPentostatin in steroid-refractory acute graft-versus-host diseaseQ28245825
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An irradiation-free nonmyeloablative bone marrow transplantation model: importance of the balance between donor T-cell number and the intensity of conditioningQ33228033
Pentostatin and cyclophosphamide: an effective new regimen in previously treated patients with chronic lymphocytic leukemiaQ33347187
Hairy-cell leukemia: induction of complete remission with pentostatin (2'-deoxycoformycin)Q33477151
Successful treatment of metastatic renal cell carcinoma with a nonmyeloablative allogeneic peripheral-blood progenitor-cell transplant: evidence for a graft-versus-tumor effect.Q33880215
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Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivoQ35847438
Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cellsQ35995727
Acute rejection of murine bone marrow allografts by natural killer cells and T cells. Differences in kinetics and target antigens recognizedQ36357551
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Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activityQ36683412
Graft rejection as a Th1-type process amenable to regulation by donor Th2-type cells through an interleukin-4/STAT6 pathwayQ37002030
Therapeutic benefit of pentostatin in severe IL-10-/- colitisQ42705209
DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4-hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabineQ43797685
Lymphodepleting effects and safety of pentostatin for nonmyeloablative allogeneic stem-cell transplantation1Q44591461
A novel reduced intensity regimen for allogeneic hematopoietic stem cell transplantation associated with a reduced incidence of graft-versus-host diseaseQ44780698
Protection against fludarabine neurotoxicity in leukemic mice by the nucleoside transport inhibitor nitrobenzylthioinosineQ45209859
Metabolism and therapeutic efficacy of 9-beta-D-arabinofuranosyl-2-fluoroadenine against murine leukemia P388Q70366787
Specificity of systems mediating transport of adenosine, 9-beta-d-arabinofuranosyl-2-fluoroadenine, and other purine nucleoside analogues in L1210 cellsQ71726052
Specific immunosuppressive effects of constant infusion of 2'-deoxycoformycinQ72089799
Combination therapy with nucleoside analogs and alkylating agentsQ72350582
The role of host T cell subsets in bone marrow rejection directed to isolated major histocompatibility complex class I versus class II differences of bm1 and bm12 mutant miceQ72667919
Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy: harnessing graft-versus-leukemia without myeloablative therapyQ73436821
CD3/CD28-costimulated T1 and T2 subsets: differential in vivo allosensitization generates distinct GVT and GVHD effectsQ73652703
An immunoablative regimen of fludarabine and cyclophosphamide prevents fully MHC-mismatched murine marrow graft rejection independent of GVHDQ73803732
Stable mixed hematopoietic chimerism in dog leukocyte antigen-identical littermate dogs given lymph node irradiation before and pharmacologic immunosuppression after marrow transplantationQ78039826
Adenosine-deaminase deficiency in two patients with severely impaired cellular immunityQ93729850
P433issue5
P304page(s)620-631
P577publication date2010-12-03
P1433published inBiology of Blood and Marrow TransplantationQ15754328
P1476titleThe pentostatin plus cyclophosphamide nonmyeloablative regimen induces durable host T cell functional deficits and prevents murine marrow allograft rejection
P478volume17

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cites work (P2860)
Q37206443A pilot pharmacologic biomarker study in HLA-haploidentical hematopoietic cell transplant recipients
Q28085551Advances in anticancer immunotoxin therapy
Q37397003Conditioning with Fludarabine-Busulfan versus Busulfan-Cyclophosphamide Is Associated with Lower aGVHD and Higher Survival but More Extensive and Long Standing Bone Marrow Damage.
Q38105635Emerging drugs for prevention of graft failure after allogeneic hematopoietic stem cell transplantation
Q36117735High-Dose Sirolimus and Immune-Selective Pentostatin plus Cyclophosphamide Conditioning Yields Stable Mixed Chimerism and Insufficient Graft-versus-Tumor Responses
Q35262181Immunopathological changes in the brain of immunosuppressed mice experimentally infected with Toxocara canis
Q37684156Immunotoxin Therapy for Lung Cancer
Q36435150MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Q52603959Myeloid Conditioning with c-kit-Targeted CAR-T Cells Enables Donor Stem Cell Engraftment.
Q35023967Pentostatin plus cyclophosphamide safely and effectively prevents immunotoxin immunogenicity in murine hosts
Q36341861Phase II study of CD4+-guided pentostatin lymphodepletion and pharmacokinetically targeted busulfan as conditioning for hematopoietic cell allografting.
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