Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis

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Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis is …
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scholarly articleQ13442814

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P356DOI10.1093/NAR/GKU1145
P8608Fatcat IDrelease_az7ssfaaf5ae7d4ir5kmt5nyaq
P932PMC publication ID4267622
P698PubMed publication ID25398907
P5875ResearchGate publication ID268336068

P50authorAndrew H.-J. WangQ10414373
P2093author name stringPei-Jung Lu
Wen-Yih Jeng
Wen-Chang Chang
Jan-Jong Hung
Jian-Ying Chuang
Chia-I Liu
Hang-Che Yang
P2860cites workAn overview of Cdk1-controlled targets and processesQ21203553
Function of WW domains as phosphoserine- or phosphothreonine-binding modulesQ22008803
Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migrationQ24300760
Cdc2: a monopotent or pluripotent CDK?Q24300976
HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA bindingQ24302225
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta productionQ24309767
The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcriptionQ24313686
Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neuronsQ24313838
The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancerQ24317638
Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNAQ24321263
Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.Q24535558
The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteinsQ24606249
Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteinsQ26825421
Structural Basis for High-Affinity Peptide Inhibition of Human Pin1Q27644848
Structure-based design of novel human Pin1 inhibitors (I)Q27657296
Structure-based design of novel human Pin1 inhibitors (II)Q27660130
Coot: model-building tools for molecular graphicsQ27860505
REFMAC5 for the refinement of macromolecular crystal structuresQ27860905
Regulation of cell cycle-specific gene expression through cyclin-dependent kinase-mediated phosphorylation of the forkhead transcription factor Fkh2pQ27937532
A human peptidyl-prolyl isomerase essential for regulation of mitosisQ28117639
Phosphorylation-dependent proline isomerization catalyzed by Pin1 is essential for tumor cell survival and entry into mitosisQ28143342
The splicing factor U1C represses EWS/FLI-mediated transactivationQ28145198
Phosphorylation-specific prolyl isomerization: is there an underlying theme?Q28248256
Prolyl cis-trans isomerization as a molecular timerQ28249249
Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1Q28267881
Sumoylation of specificity protein 1 augments its degradation by changing the localization and increasing the specificity protein 1 proteolytic processQ28284760
Cell-cycle related regulation of poly(A) polymerase by phosphorylationQ28296745
NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein functionQ29871442
Modulation of Sp1 phosphorylation by human immunodeficiency virus type 1 Tat.Q33782959
Fibronectin and wound healingQ34244999
Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical protein kinase C-zetaQ34277377
Distribution of Fibronectin During Wound Healing in VivoQ34282481
Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcriptionQ34519755
Polo-like kinases: positive regulators of cell division from start to finish.Q34663706
The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells.Q34714155
Prevalent overexpression of prolyl isomerase Pin1 in human cancersQ35097986
Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.Q35518170
Modulation of transcription factor Sp1 by cAMP-dependent protein kinase.Q52553797
Interplay of posttranslational modifications in Sp1 mediates Sp1 stability during cell cycle progression.Q53214008
Overexpression of HDAC1 induces cellular senescence by Sp1/PP2A/pRb pathway.Q53260324
PIN1, the cell cycle and cancer.Q53561253
Enrichment of cell populations in metaphase, anaphase, and telophase by synchronization using nocodazole and blebbistatin: A novel method suitable for examining dynamic changes in proteins during mitotic progressionQ58430648
Sp1 Is Phosphorylated and Its DNA Binding Activity Down-regulated upon Terminal Differentiation of the LiverQ71823770
Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteinsQ73221725
Casein kinase II-mediated phosphorylation of the C terminus of Sp1 decreases its DNA binding activityQ73343226
EWS.Fli-1 fusion protein interacts with hyperphosphorylated RNA polymerase II and interferes with serine-arginine protein-mediated RNA splicingQ74303777
Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cellsQ80579705
Proteomic analysis of human pleural effusionQ81342907
A critical step for JNK activation: isomerization by the prolyl isomerase Pin1Q35657377
The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis.Q35982124
Sp1: regulation of gene expression by phosphorylationQ36074879
Functional role of post-translational modifications of Sp1 in tumorigenesisQ36416763
Targeting carcinogenesis: a role for the prolyl isomerase Pin1?Q36465488
Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosisQ36488969
Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibilityQ36568052
Protective effect of nectandrin B, a potent AMPK activator on neointima formation: inhibition of Pin1 expression through AMPK activation.Q36781059
The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and diseaseQ36945537
Cyclin-dependent kinase 1-dependent phosphorylation of cAMP response element-binding protein decreases chromatin occupancyQ37099690
Sp1 phosphorylation and its regulation of gene transcription.Q37410727
Multifaceted polo-like kinases: drug targets and antitargets for cancer therapyQ37776652
The role of Sp1 and Sp3 in normal and cancer cell biologyQ37784574
Ewing sarcoma protein: a key player in human cancerQ38148162
Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cellsQ39827180
Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activationQ39895861
Sp1 and Sp3 foci distribution throughout mitosisQ40313333
The role of alpha 4 beta 1 integrin in cell motility and fibronectin matrix assembly.Q41377579
Cdk1 is sufficient to drive the mammalian cell cycleQ41791627
NuMA is required for the organization of microtubules into aster-like mitotic arrays.Q42771645
Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytesQ42820082
Mitotic regulation of SEPT9 protein by cyclin-dependent kinase 1 (Cdk1) and Pin1 protein is important for the completion of cytokinesisQ42946509
Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 functionQ43809033
Role of Rac1 in fibronectin-induced adhesion and motility of human corneal epithelial cellsQ44567726
The prolyl isomerase Pin1 interacts with and downregulates the activity of AMPK leading to induction of tumorigenicity of hepatocarcinoma cellsQ44785984
A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly.Q45345058
Cell Cycle-Regulated Transcription through the FHA Domain of Fkh2p and the Coactivator Ndd1pQ47592132
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)13573-13587
P577publication date2014-11-14
P1433published inNucleic Acids ResearchQ135122
P1476titlePin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis
P478volume42

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cites work (P2860)
Q38811244Estradiol differentially induces progesterone receptor isoforms expression through alternative promoter regulation in a mouse embryonic hypothalamic cell line
Q47293210MicroRNA-296 targets specificity protein 1 to suppress cell proliferation and invasion in cervical cancer
Q95277361Phosphorylation-Dependent Pin1 Isomerization of ATR: Its Role in Regulating ATR's Anti-apoptotic Function at Mitochondria, and the Implications in Cancer
Q91714281Pinning Down the Transcription: A Role for Peptidyl-Prolyl cis-trans Isomerase Pin1 in Gene Expression
Q35553540Sp1 Mediates a Therapeutic Role of MiR-7a/b in Angiotensin II-Induced Cardiac Fibrosis via Mechanism Involving the TGF-β and MAPKs Pathways in Cardiac Fibroblasts
Q41453815Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase

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