The common modification in alphaA-crystallin in the lens, N101D, is associated with increased opacity in a mouse model

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The common modification in alphaA-crystallin in the lens, N101D, is associated with increased opacity in a mouse model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.148627
P932PMC publication ID3064212
P698PubMed publication ID21245144

P2093author name stringOm P Srivastava
Ratna Gupta
Chinwe O Asomugha
P2860cites workElectrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applicationsQ24561689
Analysis of nuclear fiber cell compaction in transparent and cataractous diabetic human lenses by scanning electron microscopyQ24796936
Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lensQ24798190
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Intact AQP0 performs cell-to-cell adhesionQ27967665
The major in vivo modifications of the human water-insoluble lens crystallins are disulfide bonds, deamidation, methionine oxidation and backbone cleavageQ28142819
Age-related changes in human lens crystallins identified by two-dimensional electrophoresis and mass spectrometryQ28279428
Alpha-crystallin expression affects microtubule assembly and prevents their aggregationQ28585733
Knockout of the intermediate filament protein CP49 destabilises the lens fibre cell cytoskeleton and decreases lens optical quality, but does not induce cataractQ28586175
Reduced survival of lens epithelial cells in the alphaA-crystallin-knockout mouseQ28588245
Alpha-crystallin can function as a molecular chaperoneQ29618672
Transgenic overexpression of connexin50 induces cataractsQ30479349
Development- and differentiation-dependent reorganization of intermediate filaments in fiber cells.Q30655694
Effect of deamidation of asparagine 146 on functional and structural properties of human lens alphaB-crystallinQ31033956
Interaction of major intrinsic protein (aquaporin-0) with fiber connexins in lens developmentQ31040639
The interrelationship of lens anatomy and optical quality. I. Non-primate lensesQ32102417
Decreased caspase-3 activity in human lens epithelium from posterior subcapsular cataractsQ33185924
Deamidation affects structural and functional properties of human alphaA-crystallin and its oligomerization with alphaB-crystallinQ33205334
Age-related compaction of lens fibers affects the structure and optical properties of rabbit lenses.Q33311613
Structural and functional roles of deamidation and/or truncation of N- or C-termini in human alpha A-crystallinQ33364507
AlphaA-crystallin R49Cneo mutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in miceQ33484430
Age-dependent deamidation of lifelong proteins in the human lensQ33522366
Identification of crystallin modifications in the human lens cortex and nucleus using laser capture microdissection and CyDye labelingQ33547400
Lens optical quality is a direct function of lens sutural architectureQ33608008
Lens cytoplasmic phase separationQ33769775
alpha-Crystallin chaperone-like activity and membrane binding in age-related cataractsQ33989116
Structural and functional changes in the alpha A-crystallin R116C mutant in hereditary cataractsQ33989123
Molecular solutions to mammalian lens transparency.Q34302099
Ageing and vision: structure, stability and function of lens crystallinsQ34339776
Quantitation of asparagine-101 deamidation from alpha-A crystallin during aging of the human lensQ34464118
Fibre cell organization in crystalline lensesQ35755221
A transgenic mouse model for human autosomal dominant cataractQ35757577
Growth factor regulation of lens developmentQ36070744
Lenticular intermediate-sized filaments: biosynthesis and interaction with plasma membraneQ36296241
Role of short-range protein interactions in lens opacificationsQ36569375
The lens epithelium: focus on the expression and function of the alpha-crystallin chaperonesQ36627873
Protein-protein interactions between lens vimentin and alphaB-crystallin using FRET acceptor photobleaching.Q36749471
Deamidation in human lens betaB2-crystallin destabilizes the dimerQ36869359
Age-related changes in human crystallins determined from comparative analysis of post-translational modifications in young and aged lens: does deamidation contribute to crystallin insolubility?Q36876664
The heritability of age-related cortical cataract: the twin eye study.Q39559899
Deamidation destabilizes and triggers aggregation of a lens protein, betaA3-crystallin.Q42417058
Differential requirement for beta-catenin in epithelial and fiber cells during lens developmentQ42439342
Expression and regulation of alpha-, beta-, and gamma-crystallins in mammalian lens epithelial cellsQ42468382
Deamidation, but not truncation, decreases the urea stability of a lens structural protein, betaB1-crystallinQ44220139
Insertion of MP20 into lens fibre cell plasma membranes correlates with the formation of an extracellular diffusion barrier.Q44612383
Contributions by members of the TGFbeta superfamily to lens developmentQ45159294
Overexpression and properties of wild-type and Tyr437His mutated myocilin in the eyes of transgenic miceQ45205267
Age-related changes in human lens crystallins identified by HPLC and mass spectrometryQ47694043
Quantitative assessment of lens opacities with anterior segment optical coherence tomography.Q51867548
Ectopic expression of AP-2alpha transcription factor in the lens disrupts fiber cell differentiation.Q52120953
Short-range order of crystallin proteins accounts for eye lens transparencyQ59061608
Binding of actin to lens alpha crystallinsQ67574662
Lamellar separation in the human lens: the case for fibre folds. A combined in vivo and electron microscopy studyQ69456316
Plasma membrane-cytoskeleton damage in eye lenses of transgenic mice expressing desminQ70244809
Distribution and type of morphological damage in human nuclear age-related cataractsQ71215244
Covalent modification at the C-terminal end of a 9 kDa gamma D-crystallin fragment in human lensesQ72716249
Lens cytoskeleton and transparency: a modelQ73338517
A possible role for alpha-crystallins in lens epithelial cell differentiationQ73794550
Increased deamidation of asparagine during human senile cataractogenesisQ74281405
The structure of posterior subcapsular cataracts in the Royal College of Surgeons (RCS) ratsQ77228423
Post-translational modifications in the nuclear region of young, aged, and cataract human lensesQ81156566
P4510describes a project that usesImageJQ1659584
P433issue13
P407language of work or nameEnglishQ1860
P304page(s)11579-11592
P577publication date2011-01-18
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe common modification in alphaA-crystallin in the lens, N101D, is associated with increased opacity in a mouse model
P478volume286

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cites work (P2860)
Q36286010Enhancement of ubiquitin conjugation activity reduces intracellular aggregation of V76D mutant γD-crystallin
Q47807668Evolutionary Origins of Pax6 Control of Crystallin Genes
Q41819336Intact and N- or C-terminal end truncated AQP0 function as open water channels and cell-to-cell adhesion proteins: end truncation could be a prelude for adjusting the refractive index of the lens to prevent spherical aberration
Q43475417Lens density tracking in mice by Scheimpflug imaging
Q34341725Molecular mechanism of formation of cortical opacity in CRYAAN101D transgenic mice
Q34348758Nuclear removal during terminal lens fiber cell differentiation requires CDK1 activity: appropriating mitosis-related nuclear disassembly
Q42176248Oligomerization with wt αA- and αB-crystallins reduces proteasome-mediated degradation of C-terminally truncated αA-crystallin
Q34999320The cellular and molecular mechanisms of vertebrate lens development
Q35060283Thermal stress induced aggregation of aquaporin 0 (AQP0) and protection by α-crystallin via its chaperone function

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